Cell-permeable, irreversible inhibitor of caspase-3/CPP32; inhibits tumor cell apoptosis. Neuroprotective in rat hippocampus following seizures in vivo.
(Modifications: Asp-1 = Z-Asp(OMe), Glu-2 = Glu(OMe), Asp-4 = (OMe)-fluoromethylketone)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 13.37 mg/ml in DMSO|
Preparing Stock Solutions
The following data is based on the product molecular weight 668.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.5 mL||7.48 mL||14.96 mL|
|5 mM||0.3 mL||1.5 mL||2.99 mL|
|10 mM||0.15 mL||0.75 mL||1.5 mL|
|50 mM||0.03 mL||0.15 mL||0.3 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Brocksted et al (1998) Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. J.Biol.Chem. 273 28057 PMID: 9774422
Henshall et al (2000) Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures. J.Neurochem. 74 1215 PMID: 10693954
Kugawa et al (2000) Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway. Biol.Pharm.Bull. 23 930 PMID: 10963298
If you know of a relevant reference for Z-DEVD-FMK, please let us know.
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Keywords: Cell-permeable irreversible caspase-3 inhibitors inhibits Caspases Proteinases Proteases Caspases
4 Citations for Z-DEVD-FMK
Citations are publications that use Tocris products. Selected citations for Z-DEVD-FMK include:
Wu et al (2016) Human genome-wide RNAi screen reveals host factors required for enterovirus 71 replication Nature Communications 7 13150 PMID: 27748395
Bill et al (2015) ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer. BMB Rep 6 9173 PMID: 25823819
Im-aram et al (2013) The mTORC2 component rictor contributes to cisplatin resistance in human ovarian cancer cells. PLoS One 8 e75455 PMID: 24086535
Woo et al (2012) Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking. J Biol Chem 287 3963 PMID: 22117079
Do you know of a great paper that uses Z-DEVD-FMK from Tocris? If so please let us know.
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