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Cell-permeable, irreversible inhibitor of caspase-3/CPP32; inhibits tumor cell apoptosis. Neuroprotective in rat hippocampus following seizures in vivo.
(Modifications: Asp-1 = Z-Asp(OMe), Glu-2 = Glu(OMe), Asp-4 = (OMe)-fluoromethylketone)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 13.37 mg/ml in DMSO|
References are publications that support the biological activity of the product.
Brocksted et al (1998) Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. J.Biol.Chem. 273 28057 PMID: 9774422
Henshall et al (2000) Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures. J.Neurochem. 74 1215 PMID: 10693954
Kugawa et al (2000) Apoptosis of NG108-15 cells induced by Bupren. hydrochloride occurs via the caspase-3 pathway. Biol.Pharm.Bull. 23 930 PMID: 10963298
If you know of a relevant reference for Z-DEVD-FMK, please let us know.
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Keywords: Z-DEVD-FMK, Z-DEVD-FMK supplier, Cell-permeable, irreversible, caspase-3, inhibitors, inhibits, Caspases, Proteinases, Proteases, 2166, Tocris Bioscience
7 Citations for Z-DEVD-FMK
Citations are publications that use Tocris products. Selected citations for Z-DEVD-FMK include:
Wu et al (2016) Human genome-wide RNAi screen reveals host factors required for enterovirus 71 replication Nature Communications 7 13150 PMID: 27748395
Plouffe et al (2012) Hyperphosphorylation and cleavage at D421 enhance tau secretion. PLoS One 7 e36873 PMID: 22615831
Im-aram et al (2013) The mTORC2 component rictor contributes to cisp. resistance in human ovarian cancer cells. PLoS One 8 e75455 PMID: 24086535
Bill et al (2015) ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer. BMB Rep 6 9173 PMID: 25823819
Woo et al (2012) Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking. J Biol Chem 287 3963 PMID: 22117079
Gallagher et al (2017) Lysosomotropism depends on glucose: a chloroquine resistance mechanism. Cell Death Dis 8 e3014 PMID: 28837152
Henson et al (2017) Long-term depression-associated signaling is required for an in vitro model of NMDA receptor-dependent synapse pruning. Neurobiol Learn Mem 138 39 PMID: 27794462
Do you know of a great paper that uses Z-DEVD-FMK from Tocris? Please let us know.
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Literature in this Area
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