Description: Cell-permeable, irreversible caspase-3 inhibitor
Chemical Name: Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
Citations (8)
Literature (6)

Biological Activity for Z-DEVD-FMK

Z-DEVD-FMK is a cell-permeable, irreversible inhibitor of caspase-3/CPP32; inhibits tumor cell apoptosis. Neuroprotective in rat hippocampus following seizures in vivo.

Technical Data for Z-DEVD-FMK

M. Wt 668.67
Formula C30H41FN4O12
Sequence DEVD

(Modifications: Asp-1 = Z-Asp(OMe), Glu-2 = Glu(OMe), Asp-4 = (OMe)-fluoromethylketone)

Storage Store at -20°C
CAS Number 210344-95-9
PubChem ID 16760394
Smiles [H]N([C@@H](CC(=O)OC)C(=O)N[C@@H](CCC(=O)OC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)OC)C(=O)CF)C(=O)OCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Z-DEVD-FMK

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References for Z-DEVD-FMK

References are publications that support the biological activity of the product.

Brocksted et al (1998) Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. J.Biol.Chem. 273 28057 PMID: 9774422

Henshall et al (2000) Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures. J.Neurochem. 74 1215 PMID: 10693954

Kugawa et al (2000) Apoptosis of NG108-15 cells induced by Bupren. hydrochloride occurs via the caspase-3 pathway. Biol.Pharm.Bull. 23 930 PMID: 10963298

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Keywords: Z-DEVD-FMK, Z-DEVD-FMK supplier, Cell-permeable, irreversible, caspase-3, inhibitors, inhibits, Caspases, Proteinases, Proteases, 2166, Tocris Bioscience

8 Citations for Z-DEVD-FMK

Citations are publications that use Tocris products. Selected citations for Z-DEVD-FMK include:

Im-aram et al (2013) The mTORC2 component rictor contributes to cisp. resistance in human ovarian cancer cells. PLoS One 8 e75455 PMID: 24086535

Wu et al (2016) Human genome-wide RNAi screen reveals host factors required for enterovirus 71 replication Nature Communications 7 13150 PMID: 27748395

Bill et al (2015) ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer. BMB Rep 6 9173 PMID: 25823819

Gallagher et al (2017) Lysosomotropism depends on glucose: a chloroquine resistance mechanism. Cell Death Dis 8 e3014 PMID: 28837152

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Literature in this Area

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