Inhibitor of prolyl endopeptidase, a serine peptidase that may be implicated in the biosynthesis of amyloid β-peptide. Potently inhibits rat brain prolyl endopeptidase (Ki = 0.95 nM) in vitro, and prevents amyloid β-peptide deposition in vivo. Orally active and brain penetrant.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|ethanol||7.63||15 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 508.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.15 mM||13.11 mL||65.53 mL||131.06 mL|
|0.75 mM||2.62 mL||13.11 mL||26.21 mL|
|1.5 mM||1.31 mL||6.55 mL||13.11 mL|
|7.5 mM||0.26 mL||1.31 mL||2.62 mL|
References are publications that support the biological activity of the product.
Kato et al (1997) Prevention of amyloid-like deposition by a selective prolyl endopeptidase inhibitor, Y-29794, in senescence-accelerated mouse. J.Pharmacol.Exp.Ther. 283 328 PMID: 9336340
Nakajima et al (1992) Y-29794 - a non-peptide prolyl endopeptidase inhibitor that can penetrate into the brain. Neurosci.Lett. 141 156 PMID: 1436628
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Keywords: Y-29794 oxalate, Y-29794 oxalate supplier, Prolyl, endopeptidase, inhibitors, inhibits, prolyl, prevents, amyloid, β-peptide, beta-peptide-like, deposition, vivo, Proteases, Proteinases, Beta, Amyloid, Precursor, Protein, APP, Secretase, beta, Peptides, amyloidbeta, amyloidb, Other, 1634, Tocris Bioscience
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