Y-29794 oxalate

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Cat.No. 1634 - Y-29794 oxalate | C23H34N2OS2.C2H2O4 | CAS No. 146794-84-5
Description: Prolyl endopeptidase inhibitor
Chemical Name: [2-[[8-(Dimethylamino)octyl]thio]-6-(1-methylethyl)-3-pyridinyl]-2-thienylmethanone oxalate
Purity: ≥96% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of prolyl endopeptidase, a serine peptidase that may be implicated in the biosynthesis of amyloid β-peptide. Potently inhibits rat brain prolyl endopeptidase (Ki = 0.95 nM) in vitro, and prevents amyloid β-peptide deposition in vivo. Orally active and brain penetrant.

Technical Data

M. Wt 508.69
Formula C23H34N2OS2.C2H2O4
Storage Store at -20°C
Purity ≥96% (HPLC)
CAS Number 146794-84-5
PubChem ID 45073463
InChI Key UUSSHPPSOUAHHP-UHFFFAOYSA-N
Smiles O=C(C2=CC=CS2)C1=CC=C(C(C)C)N=C1SCCCCCCCCN(C)C.O=C(C(=O)O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.63 15
ethanol 7.63 15mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 508.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.97 mL 9.83 mL 19.66 mL
5 mM 0.39 mL 1.97 mL 3.93 mL
10 mM 0.2 mL 0.98 mL 1.97 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Kato et al (1997) Prevention of amyloid-like deposition by a selective prolyl endopeptidase inhibitor, Y-29794, in senescence-accelerated mouse. J.Pharmacol.Exp.Ther. 283 328 PMID: 9336340

Nakajima et al (1992) Y-29794 - a non-peptide prolyl endopeptidase inhibitor that can penetrate into the brain. Neurosci.Lett. 141 156 PMID: 1436628


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Keywords: Prolyl endopeptidase inhibitors inhibits prolyl prevents amyloid β-peptide beta-peptide-like deposition vivo Proteases Proteinases Beta Amyloid Precursor Protein APP Secretase beta Peptides amyloidbeta amyloidb Other Proteases

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