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XMU MP 1 is a potent and selective ATP-competitive mammalian sterile 20-like kinase (MST) 1/2 inhibitor (IC50 values are 38.1 and 71.1 nM for MST2 and MST1, respectively). Enhances activity of downstream YAP in vitro. Augments mouse intestinal repair and promotes liver repair and regeneration in a mouse model of acute and chronic liver injury. Orally bioavailable.
Sold under license from Dana-Farber Cancer Institute.
XMU MP 1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 416.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.4 mL||12.01 mL||24.01 mL|
|5 mM||0.48 mL||2.4 mL||4.8 mL|
|10 mM||0.24 mL||1.2 mL||2.4 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
References are publications that support the biological activity of the product.
Fan et al (2016) Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration. Sci.Transl.Med. 8 352 PMID: 27535619
Ray et al (2016) Therapy: Targeting liver tissue repair and regeneration. Nat.Rev.Gastroenterol.Hepatol. 13 559 PMID: 27605063
Crunkhorn et al (2016) Regenerative medicine: Inhibiting Hippo repairs tissue. Nat.Rev.Drug Discov. 15 678 PMID: 27681796
If you know of a relevant reference for XMU MP 1, please let us know.
Keywords: XMU MP 1, XMU MP 1 supplier, XMUMP1, potent, selective, MST1, MST2, Inhibitors, inhibits, tissue, regeneration, liver, repair, orally, bioavailable, mammalian, sterile, 20-like, kinase, Ste20, Hippo/Yap, signaling, Other, Kinases, 6482, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for XMU MP 1 include:
Turunen et al (2019) FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis. Cell Death Differ PMID: 30903103
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