Pricing Availability   Qty
Description: Potent and selective MST1/2 inhibitor; orally bioavailable
Chemical Name: 4-[(6,10-Dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide
Purity: ≥98% (HPLC)
Citations (5)

Biological Activity for XMU MP 1

XMU MP 1 is a potent and selective ATP-competitive mammalian sterile 20-like kinase (MST) 1/2 inhibitor (IC50 values are 38.1 and 71.1 nM for MST2 and MST1, respectively). Enhances activity of downstream YAP in vitro. Augments mouse intestinal repair and promotes liver repair and regeneration in a mouse model of acute and chronic liver injury. Orally bioavailable.

Licensing Information

Sold under license from Dana-Farber Cancer Institute.

Compound Libraries for XMU MP 1

XMU MP 1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for XMU MP 1

M. Wt 416.48
Formula C17H16N6O3S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2061980-01-4
PubChem ID 121499143
Smiles CN1C2=C(C(N(C3=CN=C(N=C13)NC4=CC=C(S(N)(=O)=O)C=C4)C)=O)SC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for XMU MP 1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 41.65 100

Preparing Stock Solutions for XMU MP 1

The following data is based on the product molecular weight 416.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.4 mL 12.01 mL 24.01 mL
5 mM 0.48 mL 2.4 mL 4.8 mL
10 mM 0.24 mL 1.2 mL 2.4 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets for XMU MP 1

Certificate of Analysis / Product Datasheet
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References for XMU MP 1

References are publications that support the biological activity of the product.

Fan et al (2016) Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration. Sci.Transl.Med. 8 352 PMID: 27535619

Ray et al (2016) Therapy: Targeting liver tissue repair and regeneration. Nat.Rev.Gastroenterol.Hepatol. 13 559 PMID: 27605063

Crunkhorn et al (2016) Regenerative medicine: Inhibiting Hippo repairs tissue. Nat.Rev.Drug Discov. 15 678 PMID: 27681796

If you know of a relevant reference for XMU MP 1, please let us know.

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Keywords: XMU MP 1, XMU MP 1 supplier, XMUMP1, potent, selective, MST1, MST2, Inhibitors, inhibits, tissue, regeneration, liver, repair, orally, bioavailable, mammalian, sterile, 20-like, kinase, Ste20, Hippo/Yap, signaling, Other, Kinases, 6482, Tocris Bioscience

5 Citations for XMU MP 1

Citations are publications that use Tocris products. Selected citations for XMU MP 1 include:

Ying et al (2020) Mammalian STE20-Like Kinase 2 Promotes Lipopolysaccharides-Mediated Cardiomyocyte Inflammation and Apoptosis by Enhancing Mitochondrial Fission. Front Physiol 11 897 PMID: 32848850

Janneke N et al (2020) Yap1-Driven Intestinal Repair Is Controlled by Group 3 Innate Lymphoid Cells. Cell Rep 30 37-45.e3 PMID: 31914395

Hong Wei et al (2021) Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional. Nat Commun 12 4566 PMID: 34315881

Turunen et al (2019) FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis. Cell Death Differ PMID: 30903103

Do you know of a great paper that uses XMU MP 1 from Tocris? Please let us know.

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