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XMU MP 1
Biological Activity for XMU MP 1
XMU MP 1 is a potent and selective ATP-competitive mammalian sterile 20-like kinase (MST) 1/2 inhibitor (IC50 values are 38.1 and 71.1 nM for MST2 and MST1, respectively). Enhances activity of downstream YAP in vitro. Augments mouse intestinal repair and promotes liver repair and regeneration in a mouse model of acute and chronic liver injury. Orally bioavailable.
Sold under license from Dana-Farber Cancer Institute.
Compound Libraries for XMU MP 1
Technical Data for XMU MP 1
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for XMU MP 1
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for XMU MP 1
The following data is based on the product molecular weight 416.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.4 mL||12.01 mL||24.01 mL|
|5 mM||0.48 mL||2.4 mL||4.8 mL|
|10 mM||0.24 mL||1.2 mL||2.4 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
References for XMU MP 1
References are publications that support the biological activity of the product.
Fan et al (2016) Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration. Sci.Transl.Med. 8 352 PMID: 27535619
Ray et al (2016) Therapy: Targeting liver tissue repair and regeneration. Nat.Rev.Gastroenterol.Hepatol. 13 559 PMID: 27605063
Crunkhorn et al (2016) Regenerative medicine: Inhibiting Hippo repairs tissue. Nat.Rev.Drug Discov. 15 678 PMID: 27681796
If you know of a relevant reference for XMU MP 1, please let us know.
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Keywords: XMU MP 1, XMU MP 1 supplier, XMUMP1, potent, selective, MST1, MST2, Inhibitors, inhibits, tissue, regeneration, liver, repair, orally, bioavailable, mammalian, sterile, 20-like, kinase, Ste20, Hippo/Yap, signaling, Other, Kinases, 6482, Tocris Bioscience
5 Citations for XMU MP 1
Citations are publications that use Tocris products. Selected citations for XMU MP 1 include:
Turunen et al (2019) FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis. Cell Death Differ PMID: 30903103
Hong Wei et al (2021) Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional. Nat Commun 12 4566 PMID: 34315881
Bing et al (2022) The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1. Nat Cell Biol 24 74-87 PMID: 35027733
Ying et al (2020) Mammalian STE20-Like Kinase 2 Promotes Lipopolysaccharides-Mediated Cardiomyocyte Inflammation and Apoptosis by Enhancing Mitochondrial Fission. Front Physiol 11 897 PMID: 32848850
Janneke N et al (2020) Yap1-Driven Intestinal Repair Is Controlled by Group 3 Innate Lymphoid Cells. Cell Rep 30 37-45.e3 PMID: 31914395
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Literature in this Area
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