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Description: BET bromodomain inhibitor
Chemical Name: 4-Acetyl-N-[5-[(diethylamino)sulfonyl]-2-hydroxyphenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for XD 14
BET bromodomain inhibitor (Kd values are 160, 170, 380, 490, 830 and 850 nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2) respectively). Also inhibits BRDT(1), CBP, p300 and BRDT(2) (Kd values are 1.2, 1.6, 2.6 and 3.7 μM respectively). Attenuates proliferation of HL-60 leukemia cells in vitro.
Technical Data for XD 14
| M. Wt | 421.51 |
| Formula | C20H27N3O5S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1370888-71-3 |
| PubChem ID | 52670832 |
| InChI Key | DPBKLIVPNYGQQG-UHFFFAOYSA-N |
| Smiles | CC1=C(C(C)=O)C(CC)=C(C(NC2=CC(S(N(CC)CC)(=O)=O)=CC=C2O)=O)N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for XD 14
References for XD 14
References are publications that support the biological activity of the product.
Lucas et al (2013) 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew.Chem.Int.Ed.Engl. 52 14055 PMID: 24272870
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Keywords: XD 14, XD 14 supplier, XD14, BET, bromodomain, inhibitors, inhibits, BRD4(1), BRD4(2), BRD3(1), BRD3(2), BRD2(1), BRD2(2), BRDT(1), BRDT(2), CREBBP, EP300, epigenetics, Bromodomains, 5489, Tocris Bioscience
Citations for XD 14
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