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XD 14

Cat. No. 5489 Submit a Review Datasheet / COA / SDS

Discontinued Product

XD 14 (Cat. No. 5489) has been withdrawn from sale for commercial reasons.
Cat.No. 5489 - XD 14 | C20H27N3O5S | CAS No. 1370888-71-3
Description: BET bromodomain inhibitor
Chemical Name: 4-Acetyl-N-[5-[(diethylamino)sulfonyl]-2-hydroxyphenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (5)
Biological Activity Technical Data Datasheets References

Biological Activity for XD 14

BET bromodomain inhibitor (Kd values are 160, 170, 380, 490, 830 and 850 nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2) respectively). Also inhibits BRDT(1), CBP, p300 and BRDT(2) (Kd values are 1.2, 1.6, 2.6 and 3.7 μM respectively). Attenuates proliferation of HL-60 leukemia cells in vitro.

Technical Data for XD 14

M. Wt 421.51
Formula C20H27N3O5S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1370888-71-3
PubChem ID 52670832
InChI Key DPBKLIVPNYGQQG-UHFFFAOYSA-N
Smiles CC1=C(C(C)=O)C(CC)=C(C(NC2=CC(S(N(CC)CC)(=O)=O)=CC=C2O)=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for XD 14

References are publications that support the biological activity of the product.

Lucas et al (2013) 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew.Chem.Int.Ed.Engl. 52 14055 PMID: 24272870

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Keywords: XD 14, XD 14 supplier, XD14, BET, bromodomain, inhibitors, inhibits, BRD4(1), BRD4(2), BRD3(1), BRD3(2), BRD2(1), BRD2(2), BRDT(1), BRDT(2), CREBBP, EP300, epigenetics, Bromodomains, 5489, Tocris Bioscience

Citations for XD 14

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