WY 45233 succinate

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Cat.No. 4194 - WY 45233 succinate | C16H25NO2.C4H6O4 | CAS No. 448904-47-0
Description: Dual serotonin/noradrenalin re-uptake inhibitor
Alternative Names: Desvenlafaxine
Chemical Name: 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol succinate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Serotonin and noradrenalin reuptake inhibitor (SNRI); selective for human serotonin (SERT) and noradrenalin (NET) transporters against 96 other targets (Ki values are 40.2 and 558.4 nM for SERT and NET respectively). Inhibits [3H]5-HT and [3H]NE uptake (IC50 values are 47.3 and 531.3 nM). Salt form of the major active metabolite of venlafaxine (Cat. No. 2917).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

WY 45233 succinate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 381.46
Formula C16H25NO2.C4H6O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 448904-47-0
PubChem ID 9800068
InChI Key ORUUBRMVQCKYHB-UHFFFAOYSA-N
Smiles OC1(C(CN(C)C)C2=CC=C(O)C=C2)CCCCC1.O=C(CCC(O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.15 100
water 19.07 50

Preparing Stock Solutions

The following data is based on the product molecular weight 381.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.62 mL 13.11 mL 26.22 mL
5 mM 0.52 mL 2.62 mL 5.24 mL
10 mM 0.26 mL 1.31 mL 2.62 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Alfinito et al (2006) Pharmacokinetic and pharmacodynamic profiles of the novel serotonin and norepinephrine reuptake inhibitor desvenlafaxine succinate in ovariectomized Sprague-Dawley rats. Brain Res. 1098 71 PMID: 16764833

Deecher et al (2006) Desvenlafaxine succinate: a new serotonin and norepinephrine reuptake inhibitor. J.Pharmacol.Exp.Ther. 318 657 PMID: 16675639

Mason et al (2007) Desvenlafaxine succinate identifies novel antagonist binding determinants in the human norepinephrine transporter. J.Pharmacol.Exp.Ther. 323 720 PMID: 17673606


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Keywords: WY45233 pfizer serotonin 5-HT norepinephrine noradrenalin noradrenaline adrenergic sert net transporters reuptake inhibitors inhibits snri Desvenlafaxine 5-HT Transporters

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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

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