WY 45233 succinate
Serotonin and noradrenalin reuptake inhibitor (SNRI); selective for human serotonin (SERT) and noradrenalin (NET) transporters against 96 other targets (Ki values are 40.2 and 558.4 nM for SERT and NET respectively). Inhibits [3H]5-HT and [3H]NE uptake (IC50 values are 47.3 and 531.3 nM). Salt form of the major active metabolite of venlafaxine (Cat. No. 2917).
Sold for research purposes under agreement from Pfizer Inc.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 381.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.62 mL||13.11 mL||26.22 mL|
|5 mM||0.52 mL||2.62 mL||5.24 mL|
|10 mM||0.26 mL||1.31 mL||2.62 mL|
|50 mM||0.05 mL||0.26 mL||0.52 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Alfinito et al (2006) Pharmacokinetic and pharmacodynamic profiles of the novel serotonin and norepinephrine reuptake inhibitor desvenlafaxine succinate in ovariectomized Sprague-Dawley rats. Brain Res. 1098 71 PMID: 16764833
Deecher et al (2006) Desvenlafaxine succinate: a new serotonin and norepinephrine reuptake inhibitor. J.Pharmacol.Exp.Ther. 318 657 PMID: 16675639
Mason et al (2007) Desvenlafaxine succinate identifies novel antagonist binding determinants in the human norepinephrine transporter. J.Pharmacol.Exp.Ther. 323 720 PMID: 17673606
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Keywords: WY45233 pfizer serotonin 5-HT norepinephrine noradrenalin noradrenaline adrenergic sert net transporters reuptake inhibitors inhibits snri Desvenlafaxine 5-HT Transporters
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Literature in this Area
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.