WY 45233 succinate

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Cat.No. 4194 - WY 45233 succinate | C16H25NO2.C4H6O4 | CAS No. 448904-47-0
Description: 5-HT and NA reuptake inhibitor (SNRI)
Alternative Names: Desvenlafaxine
Chemical Name: 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol succinate
Purity: ≥99% (HPLC)
Literature (2)

Biological Activity

Serotonin and noradrenalin reuptake inhibitor (SNRI); selective for human serotonin (SERT) and noradrenalin (NET) transporters against 96 other targets (Ki values are 40.2 and 558.4 nM for SERT and NET respectively). Inhibits [3H]5-HT and [3H]NE uptake (IC50 values are 47.3 and 531.3 nM). Salt form of the major active metabolite of venlafaxine (Cat. No. 2917).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 381.46
Formula C16H25NO2.C4H6O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 448904-47-0
PubChem ID 9800068
Smiles OC1(C(CN(C)C)C2=CC=C(O)C=C2)CCCCC1.O=C(CCC(O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 19.07 50
DMSO 38.15 100

Preparing Stock Solutions

The following data is based on the product molecular weight 381.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.62 mL 13.11 mL 26.22 mL
5 mM 0.52 mL 2.62 mL 5.24 mL
10 mM 0.26 mL 1.31 mL 2.62 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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References are publications that support the biological activity of the product.

Alfinito et al (2006) Pharmacokinetic and pharmacodynamic profiles of the novel serotonin and NE reuptake inhibitor desvenlaf. succinate in ovariectomized Sprague-Dawley rats. Brain Res. 1098 71 PMID: 16764833

Deecher et al (2006) Desvenlafaxine succinate: a new serotonin and NE reuptake inhibitor. J.Pharmacol.Exp.Ther. 318 657 PMID: 16675639

Mason et al (2007) Desvenlafaxine succinate identifies novel antagonist binding determinants in the human NE transporter. J.Pharmacol.Exp.Ther. 323 720 PMID: 17673606

If you know of a relevant reference for WY 45233 succinate, please let us know.

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