ω-Conotoxin MVIIC

Pricing Availability Delivery Time Qty
Cat.No. 1084 - w-Conotoxin MVIIC | Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-NH2 (Disulfide bridges: 1 - 16, 8 - 20, 15 - 26) | CAS No. 147794-23-8
Description: Ca2+ channel blocker (N, P and Q-type)
Datasheet
Citations (3)
Literature

Biological Activity

Peptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels.

Licensing Information

Sold under license from the University of Utah.

Technical Data

M. Wt 2749
Formula C106H178N40O32S7
Sequence CKGKGAPCRKTMYDCCSGSCGRRGKC

(Modifications: Disulfide bridge between 1 - 16, 8 - 20, 15 - 26, Cys-26 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 147794-23-8
PubChem ID 90479752
InChI Key FHVUTHWUIUXZBY-IXEXBNPISA-N
Smiles [H]N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H]4CCCN4C(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)NC([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N3)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CO)NC2=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 2749. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.36 mL 1.82 mL 3.64 mL
5 mM 0.07 mL 0.36 mL 0.73 mL
10 mM 0.04 mL 0.18 mL 0.36 mL
50 mM 0.01 mL 0.04 mL 0.07 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hillyard et al (1992) A new conus peptide ligand for mammalian presynaptic Ca2+ channels. Neuron 9 69 PMID: 1352986

McDonough et al (1996) Inhibition of Ca2+ channels in rat central and peripheral neurons by ω-conotoxin MVIIC. J.Neurosci. 16 2612 PMID: 8786437


If you know of a relevant reference for ω-Conotoxin MVIIC, please let us know.

View Related Products by Product Action

View all Voltage-gated Calcium Channel (CaV) Blockers

Keywords: Ca2+ channel blockers N-type P-type Q-type Calcium CaV Channels voltage-gated voltage-dependent omega-Conotoxin ω-conotoxin MVIIC neurotoxins venoms Voltage-gated Calcium Channels

3 Citations for ω-Conotoxin MVIIC

Citations are publications that use Tocris products. Selected citations for ω-Conotoxin MVIIC include:

Pan et al (2014) σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons. PLoS One 350 290 PMID: 24891452

Maier et al (2010) Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation. J Biol Chem 285 35606 PMID: 20826795

Haeberle et al Swelling-activated Ca2+ channels trigger Ca2+ signals in Merkel cells. Nat Commun 3 e1750 PMID: 18454189


Do you know of a great paper that uses ω-Conotoxin MVIIC from Tocris? If so please let us know.

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Reviews

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Literature in this Area

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Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Pathways for ω-Conotoxin MVIIC

Protocols

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