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Peptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels.
Sold under license from the University of Utah.
(Modifications: Disulfide bridge between 1 - 16, 8 - 20, 15 - 26, Cys-26 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Hillyard et al (1992) A new conus peptide ligand for mammalian presynaptic Ca2+ channels. Neuron 9 69 PMID: 1352986
McDonough et al (1996) Inhibition of Ca2+ channels in rat central and peripheral neurons by ω-conotoxin MVIIC. J.Neurosci. 16 2612 PMID: 8786437
If you know of a relevant reference for ω-Conotoxin MVIIC, please let us know.
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Keywords: w-Conotoxin MVIIC, w-Conotoxin MVIIC supplier, Ca2+, channel, blockers, N-type, P-type, Q-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, omega-Conotoxin, ω-conotoxin, MVIIC, neurotoxins, venoms, Cav2.x, 1084, Tocris Bioscience
11 Citations for ω-Conotoxin MVIIC
Citations are publications that use Tocris products. Selected citations for ω-Conotoxin MVIIC include:
Smith et al (2013) Comparative functional expression of nAChR subtypes in rodent DRG neurons. Front Cell Neurosci 7 225 PMID: 24348328
Hashiguchi (2017) Direct versus indirect actions of ghrelin on hypothalamic NPY neurons. PLoS One 12 e0184261 PMID: 28877214
Schöbel et al (2012) Trigeminal ganglion neurons of mice show intracellular chloride accumulation and chloride-dependent amplification of capsaicin-induced responses. PLoS One 7 e48005 PMID: 23144843
Luca et al (2017) Inter-Synaptic Lateral Diffusion of GABAA Receptors Shapes Inhibitory Synaptic Currents. Neuron 95 63 PMID: 28683270
Pan et al (2014) σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons. PLoS One 350 290 PMID: 24891452
Haeberle et al (2008) Swelling-activated Ca2+ channels trigger Ca2+ signals in Merkel cells. Nat Commun 3 e1750 PMID: 18454189
Pascual-Caro et al (2018) STIM1 deficiency is linked to Alzheimer's disease and triggers cell death in SH-SY5Y cells by upregulation of L-type voltage-operated Ca2+ entry. J Mol Med (Berl) 96 1061 PMID: 30088035
Fortalezas et al (2018) Methyl-β-Cyclodextrin Impairs the Phosphorylation of the β2 Subunit of L-Type Calcium Channels and Cytosolic Calcium Homeostasis in Mature Cerebellar Granule Neurons. Int J Mol Sci 19 PMID: 30463327
Hanlon et al (2016) Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent. Breast Cancer (Dove Med Press) 8 59 PMID: 27186076
Schöbel et al (2014) Astringency is a trigeminal sensation that involves the activation of G protein-coupled signaling by phenolic compounds. Chem Senses 39 471 PMID: 24718416
Maier et al (2010) Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation. J Biol Chem 285 35606 PMID: 20826795
Do you know of a great paper that uses ω-Conotoxin MVIIC from Tocris? Please let us know.
Reviews for ω-Conotoxin MVIIC
Average Rating: 4 (Based on 1 Review.)
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We used all these compounds which were dissolved in DMSO and added to fresh culture media. Concentration reference paper PMID: 27186076
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