ω-Conotoxin MVIIC

Pricing Availability   Qty
Cat.No. 1084 - w-Conotoxin MVIIC | Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-NH2 (Disulfide bridges: 1 - 16, 8 - 20, 15 - 26) | CAS No. 147794-23-8
Description: CaV2.x blocker
Datasheet
Citations (11)
Reviews (1)
Literature (3)

Biological Activity

Peptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels.

Licensing Information

Sold under license from the University of Utah.

Technical Data

M. Wt 2749
Formula C106H178N40O32S7
Sequence CKGKGAPCRKTMYDCCSGSCGRRGKC

(Modifications: Disulfide bridge between 1 - 16, 8 - 20, 15 - 26, Cys-26 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 147794-23-8
PubChem ID 90479752
InChI Key FHVUTHWUIUXZBY-IXEXBNPISA-N
Smiles [H]N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H]4CCCN4C(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)NC([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N3)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CO)NC2=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Hillyard et al (1992) A new conus peptide ligand for mammalian presynaptic Ca2+ channels. Neuron 9 69 PMID: 1352986

McDonough et al (1996) Inhibition of Ca2+ channels in rat central and peripheral neurons by ω-conotoxin MVIIC. J.Neurosci. 16 2612 PMID: 8786437


If you know of a relevant reference for ω-Conotoxin MVIIC, please let us know.

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View all CaV2.x Channel Blockers

Keywords: w-Conotoxin MVIIC, w-Conotoxin MVIIC supplier, Ca2+, channel, blockers, N-type, P-type, Q-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, omega-Conotoxin, ω-conotoxin, MVIIC, neurotoxins, venoms, Cav2.x, 1084, Tocris Bioscience

11 Citations for ω-Conotoxin MVIIC

Citations are publications that use Tocris products. Selected citations for ω-Conotoxin MVIIC include:

Smith et al (2013) Comparative functional expression of nAChR subtypes in rodent DRG neurons. Front Cell Neurosci 7 225 PMID: 24348328

Schöbel et al (2012) Trigeminal ganglion neurons of mice show intracellular chloride accumulation and chloride-dependent amplification of capsaicin-induced responses. PLoS One 7 e48005 PMID: 23144843

Luca et al (2017) Inter-Synaptic Lateral Diffusion of GABAA Receptors Shapes Inhibitory Synaptic Currents. Neuron 95 63 PMID: 28683270

Schöbel et al (2014) Astringency is a trigeminal sensation that involves the activation of G protein-coupled signaling by phenolic compounds. Chem Senses 39 471 PMID: 24718416


Do you know of a great paper that uses ω-Conotoxin MVIIC from Tocris? Please let us know.

Reviews for ω-Conotoxin MVIIC

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breast cancer cell viability by a cannabinoid receptor 2 agonist.
By Anonymous on 03/15/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: MCF-7

We used all these compounds which were dissolved in DMSO and added to fresh culture media. Concentration reference paper PMID: 27186076

PMID: 27186076
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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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