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Submit ReviewVU 591 hydrochloride
Description: Selective Kir1.1 (ROMK) inhibitor
Chemical Name: 6-Nitro-2-[(6-nitro-1H-benzimidazol-2-yl)methoxymethyl]-1H-benzimidazole hydrochloride
Purity: ≥99% (HPLC)
Biological Activity
Selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50 = 300 nM). Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentrations up to 10 μM; does not inhibit Kir2.1, Kir2.3 or Kir4.1. Displays similar potency to VU 590 (Cat. No. 3891).
Technical Data
| M. Wt | 404.76 |
| Formula | C16H12N6O5.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1315380-70-1 |
| PubChem ID | 90488918 |
| InChI Key | PXLOUHLPDHEXCC-UHFFFAOYSA-N |
| Smiles | O=[N+]([O-])C(C=C4)=CC2=C4N=C(N2)COCC1=NC(C=CC([N+]([O-])=O)=C3)=C3N1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.83 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 404.76. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.47 mL | 12.35 mL | 24.71 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.94 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.47 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
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References
References are publications that support the biological activity of the product.
Bhave et al (2011) Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol.Pharmacol. 79 42 PMID: 20926757
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Keywords: VU 591 hydrochloride, VU 591 hydrochloride supplier, VU591, hydrochloride, romk, renal, outer, medullary, potassium, channels, kir1.1, antagonists, selective, Inward, rectifier, Potassium, Channels, 4197, Tocris Bioscience
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Reviews for VU 591 hydrochloride
Average Rating: 5 (Based on 1 Review.)
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VU 591 works to block Inwardly Rectifying Potassium Channels on a few subfamilies.
By
Anonymous on 01/16/2019
Assay Type: In Vivo
Species: Mouse
VU 591 works to block Inwardly Rectifying Potassium Channels on a few subfamilies.The blocking effect showed by VU 591 is variable on the different classes of Kir channels. Compared to VU 590 which was also used as a reference meausre its blocking action has been found to be on the lower side.Overall acts as a great measure for comparing blocking action.
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