VU 591 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 4197 - VU 591 hydrochloride | C16H12N6O5.HCl | CAS No. 1315380-70-1
Description: Selective Kir1.1 (ROMK) inhibitor
Chemical Name: 6-Nitro-2-[(6-nitro-1H-benzimidazol-2-yl)methoxymethyl]-1H-benzimidazole hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50 = 300 nM). Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentrations up to 10 μM; does not inhibit Kir2.1, Kir2.3 or Kir4.1. Displays similar potency to VU 590 (Cat. No. 3891).

Compound Libraries

VU 591 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 404.76
Formula C16H12N6O5.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1315380-70-1
PubChem ID 90488918
InChI Key PXLOUHLPDHEXCC-UHFFFAOYSA-N
Smiles O=[N+]([O-])C(C=C4)=CC2=C4N=C(N2)COCC1=NC(C=CC([N+]([O-])=O)=C3)=C3N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.83 100

Preparing Stock Solutions

The following data is based on the product molecular weight 404.76. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.47 mL 12.35 mL 24.71 mL
5 mM 0.49 mL 2.47 mL 4.94 mL
10 mM 0.25 mL 1.24 mL 2.47 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Bhave et al (2011) Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol.Pharmacol. 79 42 PMID: 20926757


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View Related Products by Product Action

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Keywords: VU591 romk renal outer medullary potassium channels kir1.1 antagonists selective Inward rectifier Potassium Channels

Citations for VU 591 hydrochloride

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