VU 591 hydrochloride

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Cat.No. 4197 - VU 591 hydrochloride | C16H12N6O5.HCl | CAS No. 1315380-70-1
Description: Selective Kir1.1 (ROMK) inhibitor
Chemical Name: 6-Nitro-2-[(6-nitro-1H-benzimidazol-2-yl)methoxymethyl]-1H-benzimidazole hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (3)

Biological Activity

Selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50 = 300 nM). Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentrations up to 10 μM; does not inhibit Kir2.1, Kir2.3 or Kir4.1. Displays similar potency to VU 590 (Cat. No. 3891).

Compound Libraries

VU 591 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 404.76
Formula C16H12N6O5.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1315380-70-1
PubChem ID 90488918
InChI Key PXLOUHLPDHEXCC-UHFFFAOYSA-N
Smiles O=[N+]([O-])C(C=C4)=CC2=C4N=C(N2)COCC1=NC(C=CC([N+]([O-])=O)=C3)=C3N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.83 100

Preparing Stock Solutions

The following data is based on the product molecular weight 404.76. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.47 mL 12.35 mL 24.71 mL
5 mM 0.49 mL 2.47 mL 4.94 mL
10 mM 0.25 mL 1.24 mL 2.47 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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References

References are publications that support the biological activity of the product.

Bhave et al (2011) Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol.Pharmacol. 79 42 PMID: 20926757


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View Related Products by Product Action

View all Inward Rectifier Potassium (Kir) Channel Blockers

Keywords: VU 591 hydrochloride, VU 591 hydrochloride supplier, VU591, hydrochloride, romk, renal, outer, medullary, potassium, channels, kir1.1, antagonists, selective, Inward, rectifier, Potassium, Channels, 4197, Tocris Bioscience

Citations for VU 591 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for VU 591 hydrochloride. Do you know of a great paper that uses VU 591 hydrochloride from Tocris? Please let us know.

Reviews for VU 591 hydrochloride

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VU 591 works to block Inwardly Rectifying Potassium Channels on a few subfamilies.
By Anonymous on 01/16/2019
Assay Type: In Vivo
Species: Mouse

VU 591 works to block Inwardly Rectifying Potassium Channels on a few subfamilies.The blocking effect showed by VU 591 is variable on the different classes of Kir channels. Compared to VU 590 which was also used as a reference meausre its blocking action has been found to be on the lower side.Overall acts as a great measure for comparing blocking action.

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