Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewVU 591 hydrochloride
Description: Selective Kir1.1 (ROMK) inhibitor
Chemical Name: 6-Nitro-2-[(6-nitro-1H-benzimidazol-2-yl)methoxymethyl]-1H-benzimidazole hydrochloride
Purity: ≥99% (HPLC)
Biological Activity
Selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50 = 300 nM). Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentrations up to 10 μM; does not inhibit Kir2.1, Kir2.3 or Kir4.1. Displays similar potency to VU 590 (Cat. No. 3891).
Technical Data
| M. Wt | 404.76 |
| Formula | C16H12N6O5.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1315380-70-1 |
| PubChem ID | 90488918 |
| InChI Key | PXLOUHLPDHEXCC-UHFFFAOYSA-N |
| Smiles | O=[N+]([O-])C(C=C4)=CC2=C4N=C(N2)COCC1=NC(C=CC([N+]([O-])=O)=C3)=C3N1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.83 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 404.76. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.47 mL | 12.35 mL | 24.71 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.94 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.47 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets
References
References are publications that support the biological activity of the product.
Bhave et al (2011) Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol.Pharmacol. 79 42 PMID: 20926757
If you know of a relevant reference for VU 591 hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: VU 591 hydrochloride, VU 591 hydrochloride supplier, VU591, hydrochloride, romk, renal, outer, medullary, potassium, channels, kir1.1, antagonists, selective, Inward, rectifier, Potassium, Channels, 4197, Tocris Bioscience
Citations for VU 591 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for VU 591 hydrochloride. Do you know of a great paper that uses VU 591 hydrochloride from Tocris? Please let us know.
Reviews for VU 591 hydrochloride
Average Rating: 5 (Based on 1 Review.)
Have you used VU 591 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
VU 591 works to block Inwardly Rectifying Potassium Channels on a few subfamilies.
By
Anonymous on 01/16/2019
Assay Type: In Vivo
Species: Mouse
VU 591 works to block Inwardly Rectifying Potassium Channels on a few subfamilies.The blocking effect showed by VU 591 is variable on the different classes of Kir channels. Compared to VU 590 which was also used as a reference meausre its blocking action has been found to be on the lower side.Overall acts as a great measure for comparing blocking action.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cardiovascular Research Product Guide
A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:
- Hypertension
- Thrombosis and Hemostasis
- Atherosclerosis
- Myocardial Infarction
- Ischemia/Reperfusion Injury
- Arrhythmias
- Heart Failure
Ion Channel Product Listing
A collection of around 500 products for ion channel research, the listing includes research tools for the study of:
- Ligand-gated ion channels
- Voltage-gated ion channels
- Other Ion Channels
Pain Research Product Guide
A collection of over 280 products for pain research, the guide includes research tools for the study of:
- Nociception
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling