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VU 590 dihydrochloride
Inhibits the renal outer medullary potassium channel (Kir1.1, ROMK) (IC50 = 294 nM). Also inhibits the inward retifying K+ channel Kir7.1; displays no effect upon Kir2.1 or Kir4.1. Acts as an intracellular Kir1.1 channel pore blocker.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 561.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.78 mL||8.91 mL||17.81 mL|
|5 mM||0.36 mL||1.78 mL||3.56 mL|
|10 mM||0.18 mL||0.89 mL||1.78 mL|
|50 mM||0.04 mL||0.18 mL||0.36 mL|
References are publications that support the biological activity of the product.
Lewis et al (2009) High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1. Mol.Pharmacol. 76 1094 PMID: 19706730
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Keywords: VU 590 dihydrochloride, VU 590 dihydrochloride supplier, Inhibitor, inhibitors, inhibits, ROMK, Kir7.1, ion, channel, blocker, blocks, permeability, VU590, dihydrochloride, renal, outer, medullary, potassium, inward, rectifying, K+, channels, Kir1.1, Inward, rectifier, Potassium, Channels, 3891, Tocris Bioscience
2 Citations for VU 590 dihydrochloride
Citations are publications that use Tocris products. Selected citations for VU 590 dihydrochloride include:
Bhave et al (2011) Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol 79 42 PMID: 20926757
Yin et al (2018) The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis. Nat Commun 9 2815 PMID: 30022023
Do you know of a great paper that uses VU 590 dihydrochloride from Tocris? Please let us know.
Reviews for VU 590 dihydrochloride
Average Rating: 5 (Based on 1 Review.)
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Vu 590 works beautifully on Inwardly Rectifying Potassium Channels but not on all subfamilies. The blocking effect showed by VU 590 is variable on the different classes of Kir channels. Overall acts as a great measure for comparing blocking action.
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