VU 590 dihydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 3891 - VU 590 dihydrochloride | C24H32N4O7.2HCl | CAS No. 1783987-83-6
Description: Inhibitor of Kir1.1 (ROMK) and Kir7.1
Chemical Name: 7,13-Bis[(4-nitrophenyl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecane dihydrochloride
Purity: ≥97% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibits the renal outer medullary potassium channel (Kir1.1, ROMK) (IC50 = 294 nM). Also inhibits the inward retifying K+ channel Kir7.1; displays no effect upon Kir2.1 or Kir4.1. Acts as an intracellular Kir1.1 channel pore blocker.

Technical Data

M. Wt 561.46
Formula C24H32N4O7.2HCl
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1783987-83-6
PubChem ID 71433535
InChI Key FRYYSUBAHIUBNJ-UHFFFAOYSA-N
Smiles O=[N+](C(C=C2)=CC=C2CN1CCOCCOCCN(CC3=CC=C([N+]([O-])=O)C=C3)CCOCC1)[O-].Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 56.15 100

Preparing Stock Solutions

The following data is based on the product molecular weight 561.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.78 mL 8.91 mL 17.81 mL
5 mM 0.36 mL 1.78 mL 3.56 mL
10 mM 0.18 mL 0.89 mL 1.78 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lewis et al (2009) High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1. Mol.Pharmacol. 76 1094 PMID: 19706730


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Keywords: Inhibitor inhibitors inhibits ROMK Kir7.1 ion channel blocker blocks permeability VU590 dihydrochloride renal outer medullary potassium inward rectifying K+ channels Kir1.1 Inward rectifier Potassium Channels

Citations for VU 590 dihydrochloride

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Literature in this Area

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