VU 590 dihydrochloride

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Cat.No. 3891 - VU 590 dihydrochloride | C24H32N4O7.2HCl | CAS No. 1783987-83-6
Description: Inhibitor of Kir1.1 (ROMK) and Kir7.1
Chemical Name: 7,13-Bis[(4-nitrophenyl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecane dihydrochloride
Purity: ≥97% (HPLC)
Datasheet
Citations (2)
Reviews (1)
Literature (3)

Biological Activity

Inhibits the renal outer medullary potassium channel (Kir1.1, ROMK) (IC50 = 294 nM). Also inhibits the inward retifying K+ channel Kir7.1; displays no effect upon Kir2.1 or Kir4.1. Acts as an intracellular Kir1.1 channel pore blocker.

Technical Data

M. Wt 561.46
Formula C24H32N4O7.2HCl
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1783987-83-6
PubChem ID 71433535
InChI Key FRYYSUBAHIUBNJ-UHFFFAOYSA-N
Smiles O=[N+](C(C=C2)=CC=C2CN1CCOCCOCCN(CC3=CC=C([N+]([O-])=O)C=C3)CCOCC1)[O-].Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 56.15 100

Preparing Stock Solutions

The following data is based on the product molecular weight 561.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.78 mL 8.91 mL 17.81 mL
5 mM 0.36 mL 1.78 mL 3.56 mL
10 mM 0.18 mL 0.89 mL 1.78 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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References

References are publications that support the biological activity of the product.

Lewis et al (2009) High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1. Mol.Pharmacol. 76 1094 PMID: 19706730


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View Related Products by Product Action

View all Inward Rectifier Potassium (Kir) Channel Blockers

Keywords: VU 590 dihydrochloride, VU 590 dihydrochloride supplier, Inhibitor, inhibitors, inhibits, ROMK, Kir7.1, ion, channel, blocker, blocks, permeability, VU590, dihydrochloride, renal, outer, medullary, potassium, inward, rectifying, K+, channels, Kir1.1, Inward, rectifier, Potassium, Channels, 3891, Tocris Bioscience

2 Citations for VU 590 dihydrochloride

Citations are publications that use Tocris products. Selected citations for VU 590 dihydrochloride include:

Bhave et al (2011) Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol 79 42 PMID: 20926757

Yin et al (2018) The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis. Nat Commun 9 2815 PMID: 30022023


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Reviews for VU 590 dihydrochloride

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Vu 590 works beautifully on Inwardly Rectifying Potassium Channels but not on all subfamilies.
By Anonymous on 10/31/2018
Assay Type: In Vitro
Species: Human

Vu 590 works beautifully on Inwardly Rectifying Potassium Channels but not on all subfamilies. The blocking effect showed by VU 590 is variable on the different classes of Kir channels. Overall acts as a great measure for comparing blocking action.

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Literature in this Area

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*Please note that Tocris will only send literature to established scientific business / institute addresses.


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