VU 0361737

Discontinued Product

VU 0361737 (Cat. No. 3707) has been withdrawn from sale for commercial reasons.
Cat.No. 3707 - VU 0361737 | C13H11ClN2O2 | CAS No. 1161205-04-4
Description: Selective positive allosteric modulator of mGlu4 receptors
Chemical Name: N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (8)

Biological Activity for VU 0361737

VU 0361737 is a selective positive allosteric modulator at mGlu4 receptors (EC50 values are 240 and 110 nM at human and rat receptors respectively). Inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors and displays weak activity at mGlu5 and mGlu8 receptors. Brain penetrant.

Technical Data for VU 0361737

M. Wt 262.69
Formula C13H11ClN2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1161205-04-4
PubChem ID 44191096
InChI Key ARYUXFNGXHNNDM-UHFFFAOYSA-N
Smiles ClC1=C(OC)C=C(NC(C2=NC=CC=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for VU 0361737

Certificate of Analysis / Product Datasheet
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Keywords: VU 0361737, VU 0361737 supplier, Selective, positive, allosteric, modulators, mGlu4, mGluR4, group, III, metabotropic, glutamate, receptors, VU0361737, PAM, Glutamate, (Metabotropic), Group, Receptors, 3707, Tocris Bioscience

1 Citation for VU 0361737

Citations are publications that use Tocris products. Selected citations for VU 0361737 include:

Jones et al (2011) Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 ( J Med Chem 54 7639 PMID: 21966889


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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