VU 0361737

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Cat.No. 3707 - VU 0361737 | C13H11ClN2O2 | CAS No. 1161205-04-4
Description: Selective positive allosteric modulator at mGlu4
Chemical Name: N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective positive allosteric modulator at mGlu4 receptors (EC50 values are 240 and 110 nM at human and rat receptors respectively). Inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors and displays weak activity at mGlu5 and mGlu8 receptors. Brain penetrant.

Compound Libraries

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Technical Data

M. Wt 262.69
Formula C13H11ClN2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1161205-04-4
PubChem ID 44191096
InChI Key ARYUXFNGXHNNDM-UHFFFAOYSA-N
Smiles ClC1=C(OC)C=C(NC(C2=NC=CC=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.27 100

Preparing Stock Solutions

The following data is based on the product molecular weight 262.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.81 mL 19.03 mL 38.07 mL
5 mM 0.76 mL 3.81 mL 7.61 mL
10 mM 0.38 mL 1.9 mL 3.81 mL
50 mM 0.08 mL 0.38 mL 0.76 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Engers et al (2009) Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs). J.Med.Chem. 52 4115 PMID: 19469556

Engers et al (2011) Discovery, synthesis, and structure-activity relationship development of a series of N-(4-Acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu4) with CNS exposure in rats. J.Med.Chem. 54 1106 PMID: 21247167


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Keywords: Selective positive allosteric modulators mGlu4 mGluR4 group III metabotropic glutamate receptors VU0361737 Glutamate (Metabotropic) Group III Receptors

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