Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewVinpocetine
Description: Na+ channel blocker
Chemical Name: (3α,16α)-Eburnamenine-14-carboxylic acid ethyl ester
Purity: ≥99% (HPLC)
Biological Activity
Phosphodiesterase inhibitor, selective for PDE1 (IC50 = 21 μM). Also blocks voltage-gated Na+ channels.
Technical Data
| M. Wt | 350.46 |
| Formula | C22H26N2O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 42971-09-5 |
| PubChem ID | 443955 |
| InChI Key | DDNCQMVWWZOMLN-IRLDBZIGSA-N |
| Smiles | O=C(OCC)C5=C[C@@]2(CC)[C@@]1([H])C4=C(C3=CC=CC=C3N45)CCN1CCC2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 17.52 | 50 | |
| DMSO | 3.5 | 10 with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 350.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.71 mL | 28.53 mL | 57.07 mL |
| 2.5 mM | 1.14 mL | 5.71 mL | 11.41 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.71 mL |
| 25 mM | 0.11 mL | 0.57 mL | 1.14 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets
References
References are publications that support the biological activity of the product.
Hagiwara et al (1984) Effect of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle. Biochem.Pharmacol. 33 453 PMID: 6322804
Molnar and Erdo (1995) Vinpocetine is as potent as phen. to block voltage-gated Na+ channels in rat cortical neurons. Eur.J.Pharmacol. 273 303 PMID: 7737339
Merck Index 12 10128
If you know of a relevant reference for Vinpocetine, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Vinpocetine, Vinpocetine supplier, PDE1, inhibitors, inhibits, Na+, channel, blockers, Phosphodiesterases, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Voltage-gated, 0757, Tocris Bioscience
2 Citations for Vinpocetine
Citations are publications that use Tocris products. Selected citations for Vinpocetine include:
Lee et al (2015) Vinpocetine inhibits Streptococcus pneumoniae-induced upregulation of mucin MUC5AC expression via induction of MKP-1 phosphatase in the pathogenesis of otitis media. EMBO Mol Med 194 5990 PMID: 25972475
Robichaud et al (2002) Assessing the emetic potential of PDE4 inhibitors in rats. Br J Pharmacol 135 113 PMID: 11786486
Do you know of a great paper that uses Vinpocetine from Tocris? Please let us know.
Reviews for Vinpocetine
There are currently no reviews for this product. Be the first to review Vinpocetine and earn rewards!
Have you used Vinpocetine?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Cardiovascular Research Product Guide
A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:
- Hypertension
- Thrombosis and Hemostasis
- Atherosclerosis
- Myocardial Infarction
- Ischemia/Reperfusion Injury
- Arrhythmias
- Heart Failure
Ion Channel Product Listing
A collection of around 500 products for ion channel research, the listing includes research tools for the study of:
- Ligand-gated ion channels
- Voltage-gated ion channels
- Other Ion Channels
Pain Research Product GuideUpdated
A collection of over 280 products for pain research, the guide includes research tools for the study of:
- Nociception
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling
Epilepsy Poster
Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.