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Biological Activity for Vinpocetine
Vinpocetine is a phosphodiesterase inhibitor, selective for PDE1 (IC50 = 21 μM). Also blocks voltage-gated Na+ channels.
Technical Data for Vinpocetine
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Vinpocetine
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||3.5||10 with gentle warming|
Preparing Stock Solutions for Vinpocetine
The following data is based on the product molecular weight 350.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.71 mL||28.53 mL||57.07 mL|
|2.5 mM||1.14 mL||5.71 mL||11.41 mL|
|5 mM||0.57 mL||2.85 mL||5.71 mL|
|25 mM||0.11 mL||0.57 mL||1.14 mL|
References for Vinpocetine
References are publications that support the biological activity of the product.
Hagiwara et al (1984) Effect of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle. Biochem.Pharmacol. 33 453 PMID: 6322804
Molnar and Erdo (1995) Vinpocetine is as potent as phen. to block voltage-gated Na+ channels in rat cortical neurons. Eur.J.Pharmacol. 273 303 PMID: 7737339
Merck Index 12 10128
If you know of a relevant reference for Vinpocetine, please let us know.
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Keywords: Vinpocetine, Vinpocetine supplier, PDE1, inhibitors, inhibits, Na+, channel, blockers, Phosphodiesterases, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Voltage-gated, 0757, Tocris Bioscience
2 Citations for Vinpocetine
Citations are publications that use Tocris products. Selected citations for Vinpocetine include:
Lee et al (2015) Vinpocetine inhibits Streptococcus pneumoniae-induced upregulation of mucin MUC5AC expression via induction of MKP-1 phosphatase in the pathogenesis of otitis media. EMBO Mol Med 194 5990 PMID: 25972475
Robichaud et al (2002) Assessing the emetic potential of PDE4 inhibitors in rats. Br J Pharmacol 135 113 PMID: 11786486
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.