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Cat.No. 0757 - Vinpocetine | C22H26N2O2 | CAS No. 42971-09-5
Description: Na+ channel blocker
Chemical Name: (3α,16α)-Eburnamenine-14-carboxylic acid ethyl ester
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity

Phosphodiesterase inhibitor, selective for PDE1 (IC50 = 21 μM). Also blocks voltage-gated Na+ channels.

Technical Data

M. Wt 350.46
Formula C22H26N2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 42971-09-5
PubChem ID 443955
Smiles O=C(OCC)C5=C[C@@]2(CC)[C@@]1([H])C4=C(C3=CC=CC=C3N45)CCN1CCC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 3.5 10mM with gentle warming
ethanol 17.52 50

Preparing Stock Solutions

The following data is based on the product molecular weight 350.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.27 mL 28.53 mL
5 mM 0.57 mL 2.85 mL 5.71 mL
10 mM 0.29 mL 1.43 mL 2.85 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Hagiwara et al (1984) Effect of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle. Biochem.Pharmacol. 33 453 PMID: 6322804

Molnar and Erdo (1995) Vinpocetine is as potent as phenytoin to block voltage-gated Na+ channels in rat cortical neurons. Eur.J.Pharmacol. 273 303 PMID: 7737339

Merck Index 12 10128 PMID:

If you know of a relevant reference for Vinpocetine, please let us know.

View Related Products by Product Action

View all Voltage-gated Sodium (NaV) Channel Blockers

Keywords: Vinpocetine, supplier, PDE1, inhibitors, inhibits, Na+, channel, blockers, Phosphodiesterases, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Voltage-gated, Sodium, Channels, Phosphodiesterases, Voltage-gated, Sodium, Channels, Tocris Bioscience

1 Citation for Vinpocetine

Citations are publications that use Tocris products. Selected citations for Vinpocetine include:

Lee et al (2015) Vinpocetine inhibits Streptococcus pneumoniae-induced upregulation of mucin MUC5AC expression via induction of MKP-1 phosphatase in the pathogenesis of otitis media. EMBO Mol Med 194 5990 PMID: 25972475

Do you know of a great paper that uses Vinpocetine from Tocris? If so please let us know.

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