Vinpocetine

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Cat.No. 0757 - Vinpocetine | C22H26N2O2 | CAS No. 42971-09-5
Description: Na+ channel blocker
Chemical Name: (3α,16α)-Eburnamenine-14-carboxylic acid ethyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Phosphodiesterase inhibitor, selective for PDE1 (IC50 = 21 μM). Also blocks voltage-gated Na+ channels.

Technical Data

M. Wt 350.46
Formula C22H26N2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 42971-09-5
PubChem ID 443955
InChI Key DDNCQMVWWZOMLN-IRLDBZIGSA-N
Smiles O=C(OCC)C5=C[C@@]2(CC)[C@@]1([H])C4=C(C3=CC=CC=C3N45)CCN1CCC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 17.52 50
DMSO 3.5 10 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 350.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.71 mL 28.53 mL 57.07 mL
2.5 mM 1.14 mL 5.71 mL 11.41 mL
5 mM 0.57 mL 2.85 mL 5.71 mL
25 mM 0.11 mL 0.57 mL 1.14 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Hagiwara et al (1984) Effect of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle. Biochem.Pharmacol. 33 453 PMID: 6322804

Molnar and Erdo (1995) Vinpocetine is as potent as phen. to block voltage-gated Na+ channels in rat cortical neurons. Eur.J.Pharmacol. 273 303 PMID: 7737339

Merck Index 12 10128


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View Related Products by Product Action

View all Voltage-gated Sodium (NaV) Channel Blockers

Keywords: Vinpocetine, Vinpocetine supplier, PDE1, inhibitors, inhibits, Na+, channel, blockers, Phosphodiesterases, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Voltage-gated, 0757, Tocris Bioscience

2 Citations for Vinpocetine

Citations are publications that use Tocris products. Selected citations for Vinpocetine include:

Lee et al (2015) Vinpocetine inhibits Streptococcus pneumoniae-induced upregulation of mucin MUC5AC expression via induction of MKP-1 phosphatase in the pathogenesis of otitis media. EMBO Mol Med 194 5990 PMID: 25972475

Robichaud et al (2002) Assessing the emetic potential of PDE4 inhibitors in rats. Br J Pharmacol 135 113 PMID: 11786486


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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