Vanilloid TRPV1 Receptor Tocriset™
Contents of Tocriset:
|Cat.No.||Product Name / Activity|
|prototypic vanilloid receptor agonist|
|vanilloid receptor antagonist|
|potent vanilloid receptor agonist|
|potent, selective, competitive TRPV1 antagonist|
|potent vanilloid TRPV1 receptor agonist|
Contains the listed products as lyophilised solids which can be used to investigate the pharmacology of vanilloid TRPV1 receptors.
Tocrisets contain 3-5 ligands supplied as lyophilized solids or pre-dissolved in DMSO at a specified concentration. Lyophilized solids have been freeze-dried (approximately 0.5-2 mg per vial) so that addition of 0.5 or 1 ml of solvent produces a stock concentration of 10 or 5 mM respectively.
Please see individual product listings for specific technical data and certificate of analysis.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
References are publications that support the products' biological activity.
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Literature in this Area
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.