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Discontinued ProductResiniferatoxin (Cat. No. 1137) has been withdrawn from sale for commercial reasons.
Biological Activity for Resiniferatoxin
Potent analog of capsaicin that is an agonist at vanilloid receptors (Ki = 43 pM). Like capsaicin, it acts as a selective modulator of primary afferent neurons.
Technical Data for Resiniferatoxin
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for Resiniferatoxin
References are publications that support the biological activity of the product.
Acs et al (1996) Distinct structure-activity relations for stimulation of 45Ca uptake and for high affinity binding in cultured rat dorsal root ganglion neurons and dorsal root ganglion membranes. Brain Res.Mol.Brain Res. 35 173 PMID: 8717353
Szolcsanyi et al (1990) Resiniferatoxin: an ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons. J.Pharmacol.Exp.Ther. 255 923 PMID: 2243359
Winter et al (1990) Cellular mechanism of action of resiniferatoxin: a potent sensory neuron excitotoxin. Brain Res. 520 131 PMID: 2169951
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Keywords: Resiniferatoxin, Resiniferatoxin supplier, Ultrapotent, vanilloid, receptor, agonist, Vanillioid, Receptors, VR1, TRPV, TRP, Channels, Transient, Receptor, Potential, 1137, Tocris Bioscience
5 Citations for Resiniferatoxin
Citations are publications that use Tocris products. Selected citations for Resiniferatoxin include:
Okun et al (2011) Transient inflammation-induced ongoing pain is driven by TRPV1 sensitive afferents. J Pharmacol Exp Ther 7 4 PMID: 21219650
Yuan and Burrell (2010) Endocannabinoid-dependent LTD in a nociceptive synapse requires activation of a presynaptic TRPV-like receptor. J Neurophysiol 104 2766 PMID: 20884761
Buznikov et al (2010) A putative 'pre-nervous' endocannabinoid system in early echinoderm development. Dev Neurosci 32 1 PMID: 19907129
Graham et al (2013) Epidermal keratinocyte polarity and motility require Ca2+ influx through TRPV1. J Cell Sci 126 4602 PMID: 23943873
Huang et al (2017) Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors. Exp Neurol 295 66 PMID: 28479337
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.