OLDA

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Cat.No. 1641 - OLDA | C26H43NO3 | CAS No. 105955-11-1
Description: Potent, selective endogenous TRPV1 agonist
Alternative Names: N-Oleoyldopamine
Chemical Name: (9Z)-N-[2-(3,4-Dihydroxyphenyl)ethyl]-9-octadecenamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent endogenous vanilloid TRPV1 (VR1) receptor agonist (EC50 = 36 nM at hVR1) with low affinity for rCB1 receptors (Ki = 1.6 μM). Potently induces VR1-mediated thermal hyperalgesia in rats in vivo.

Technical Data

M. Wt 417.63
Formula C26H43NO3
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 105955-11-1
PubChem ID 5282106
InChI Key QQBPLXNESPTPNU-KTKRTIGZSA-N
Smiles CCCCCCCC\C=C/CCCCCCCC(=O)NCCC1=CC=C(O)C(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.88 50
ethanol 20.88 50

Preparing Stock Solutions

The following data is based on the product molecular weight 417.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.39 mL 11.97 mL 23.94 mL
5 mM 0.48 mL 2.39 mL 4.79 mL
10 mM 0.24 mL 1.2 mL 2.39 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Butelman et al (2004) Anitallodynic effects of loperamide and fentanyl against topical capsaicin-induced allodynia in unanesthetized primates. J.Pharmacol.Exp.Ther. 311 155 PMID: 15152028

Chu et al (2003) N-Oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia. J.Biol.Chem. 278 13633 PMID: 12569099


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Keywords: OLDA, supplier, Potent, selective, endogenous, TRPV1, agonists, Vanillioid, Receptors, VR1, TRPV, Channels, Transient, Receptor, Potential, N-Oleoyldopamine, TRPV, TRPV, Tocris Bioscience

Citations for OLDA

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