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Biological Activity for OLDA
OLDA is a potent endogenous vanilloid TRPV1 (VR1) receptor agonist (EC50 = 36 nM at hVR1) with low affinity for rCB1 receptors (Ki = 1.6 μM). Potently induces VR1-mediated thermal hyperalgesia in rats in vivo.
Technical Data for OLDA
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for OLDA
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for OLDA
The following data is based on the product molecular weight 417.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.79 mL||23.94 mL||47.89 mL|
|2.5 mM||0.96 mL||4.79 mL||9.58 mL|
|5 mM||0.48 mL||2.39 mL||4.79 mL|
|25 mM||0.1 mL||0.48 mL||0.96 mL|
References for OLDA
References are publications that support the biological activity of the product.
Butelman et al (2004) Anitallodynic effects of loperamide and fen. against topical capsaicin-induced allodynia in unanesthetized primates. J.Pharmacol.Exp.Ther. 311 155 PMID: 15152028
Chu et al (2003) N-OleoylDA, a novel endogenous capsaicin-like lipid that produces hyperalgesia. J.Biol.Chem. 278 13633 PMID: 12569099
If you know of a relevant reference for OLDA, please let us know.
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Keywords: OLDA, OLDA supplier, Potent, selective, endogenous, TRPV1, agonists, Vanillioid, Receptors, VR1, TRPV, Channels, Transient, Receptor, Potential, N-Oleoyldopamine, 1641, Tocris Bioscience
Citations for OLDA
Citations are publications that use Tocris products.
Currently there are no citations for OLDA. Do you know of a great paper that uses OLDA from Tocris? Please let us know.
Reviews for OLDA
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.