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Description: Potent and selective endogenous TRPV1 agonist
Alternative Names: N-Oleoyldopamine
Chemical Name: (9Z)-N-[2-(3,4-Dihydroxyphenyl)ethyl]-9-octadecenamide
Purity: ≥99% (HPLC)

Biological Activity for OLDA

OLDA is a potent endogenous vanilloid TRPV1 (VR1) receptor agonist (EC50 = 36 nM at hVR1) with low affinity for rCB1 receptors (Ki = 1.6 μM). Potently induces VR1-mediated thermal hyperalgesia in rats in vivo.

Technical Data for OLDA

M. Wt 417.63
Formula C26H43NO3
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 105955-11-1
PubChem ID 5282106

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for OLDA

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 20.88 50
ethanol 20.88 50

Preparing Stock Solutions for OLDA

The following data is based on the product molecular weight 417.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.79 mL 23.94 mL 47.89 mL
2.5 mM 0.96 mL 4.79 mL 9.58 mL
5 mM 0.48 mL 2.39 mL 4.79 mL
25 mM 0.1 mL 0.48 mL 0.96 mL

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Product Datasheets for OLDA

Certificate of Analysis / Product Datasheet
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References for OLDA

References are publications that support the biological activity of the product.

Butelman et al (2004) Anitallodynic effects of loperamide and fen. against topical capsaicin-induced allodynia in unanesthetized primates. J.Pharmacol.Exp.Ther. 311 155 PMID: 15152028

Chu et al (2003) N-OleoylDA, a novel endogenous capsaicin-like lipid that produces hyperalgesia. J.Biol.Chem. 278 13633 PMID: 12569099

If you know of a relevant reference for OLDA, please let us know.

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Keywords: OLDA, OLDA supplier, Potent, selective, endogenous, TRPV1, agonists, Vanillioid, Receptors, VR1, TRPV, Channels, Transient, Receptor, Potential, N-Oleoyldopamine, 1641, Tocris Bioscience

Citations for OLDA

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