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Description: Potent TRPV agonist
Alternative Names: NE 19550
Chemical Name: N-Vanillyloleoylamide
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for Olvanil

Olvanil is a potent vanilloid receptor agonist (pEC50 values are 8.1 and 7.7 at rat and human VR1 receptors respectively). Also blocks anandamide uptake (IC50 = 9 μM) and may bind to CB1 cannabinoid receptors. Antinociceptive following systemic administration.

Technical Data for Olvanil

M. Wt 417.63
Formula C26H43NO3
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 58493-49-5
PubChem ID 5311093

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Olvanil

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 100
ethanol 25

Preparing Stock Solutions for Olvanil

The following data is based on the product molecular weight 417.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.39 mL 11.97 mL 23.94 mL
5 mM 0.48 mL 2.39 mL 4.79 mL
10 mM 0.24 mL 1.2 mL 2.39 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets for Olvanil

Certificate of Analysis / Product Datasheet
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References for Olvanil

References are publications that support the biological activity of the product.

Di Marzo et al (1998) Interactions between synthetic vanilloids and the endogenous cannabinoid system. FEBS Lett. 436 449 PMID: 9801167

Dray et al (1990) NE-19550 and NE-21610, antinociceptive capsaicin analogues: studies on nociceptive fibres of the neonatal rat tail in vitro. Eur.J.Pharmacol. 181 289 PMID: 2384136

Janusz et al (1993) Vanilloids. 1. Analogs of capsaicin with antinociceptive and antiinflammatory activity. J.Med.Chem. 36 2595 PMID: 8410971

Ralevic et al (2001) Cannabinoid activation of recombinant and endogenous vanilloid receptors. Eur.J.Pharmacol. 424 211 PMID: 11672565

If you know of a relevant reference for Olvanil, please let us know.

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Keywords: Olvanil, Olvanil supplier, Potent, vanilloid, agonists, Receptors, VR1, TRPV, TRP, Channels, Transient, Receptor, Potential, NE19550, NE, 19550, 0934, Tocris Bioscience

1 Citation for Olvanil

Citations are publications that use Tocris products. Selected citations for Olvanil include:

Witte et al (2002) Use of a fluorescent imaging plate reader--based calcium assay to assess pharmacological differences between the human and rat vanilloid receptor. Am J Physiol Endocrinol Metab 7 466 PMID: 14599363

Do you know of a great paper that uses Olvanil from Tocris? Please let us know.

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