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Olvanil

Cat. No. 0934 1 Citation Submit a Review Datasheet / COA / SDS
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Cat.No. 0934 - Olvanil | C26H43NO3 | CAS No. 58493-49-5
Description: Potent vanilloid receptor agonist
Alternative Names: NE 19550
Chemical Name: N-Vanillyloleoylamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent vanilloid receptor agonist (pEC50 values are 8.1 and 7.7 at rat and human VR1 receptors respectively). Also blocks anandamide uptake (IC50 = 9 μM) and may bind to CB1 cannabinoid receptors. Antinociceptive following systemic administration. Also available as part of the Vanilloid TRPV1 Receptor Tocriset™.

Technical Data

M. Wt 417.63
Formula C26H43NO3
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 58493-49-5
PubChem ID 5311093
InChI Key OPZKBPQVWDSATI-KHPPLWFESA-N
Smiles CCCCCCCC\C=C/CCCCCCCC(=O)NCC1=CC=C(O)C(OC)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100
ethanol 25

Preparing Stock Solutions

The following data is based on the product molecular weight 417.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.39 mL 11.97 mL 23.94 mL
5 mM 0.48 mL 2.39 mL 4.79 mL
10 mM 0.24 mL 1.2 mL 2.39 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Di Marzo et al (1998) Interactions between synthetic vanilloids and the endogenous cannabinoid system. FEBS Lett. 436 449 PMID: 9801167

Dray et al (1990) NE-19550 and NE-21610, antinociceptive capsaicin analogues: studies on nociceptive fibres of the neonatal rat tail in vitro. Eur.J.Pharmacol. 181 289 PMID: 2384136

Janusz et al (1993) Vanilloids. 1. Analogs of capsaicin with antinociceptive and antiinflammatory activity. J.Med.Chem. 36 2595 PMID: 8410971

Ralevic et al (2001) Cannabinoid activation of recombinant and endogenous vanilloid receptors. Eur.J.Pharmacol. 424 211 PMID: 11672565

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Keywords: Olvanil, Olvanil supplier, Potent, vanilloid, agonists, Receptors, VR1, TRPV, TRP, Channels, Transient, Receptor, Potential, NE19550, NE, 19550, 0934, Tocris Bioscience

1 Citation for Olvanil

Citations are publications that use Tocris products. Selected citations for Olvanil include:

Witte et al (2002) Use of a fluorescent imaging plate reader--based calcium assay to assess pharmacological differences between the human and rat vanilloid receptor. Am J Physiol Endocrinol Metab 7 466 PMID: 14599363

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Literature in this Area

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