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Biological Activity for Olvanil
Olvanil is a potent vanilloid receptor agonist (pEC50 values are 8.1 and 7.7 at rat and human VR1 receptors respectively). Also blocks anandamide uptake (IC50 = 9 μM) and may bind to CB1 cannabinoid receptors. Antinociceptive following systemic administration.
Technical Data for Olvanil
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Olvanil
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Olvanil
The following data is based on the product molecular weight 417.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.39 mL||11.97 mL||23.94 mL|
|5 mM||0.48 mL||2.39 mL||4.79 mL|
|10 mM||0.24 mL||1.2 mL||2.39 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
References for Olvanil
References are publications that support the biological activity of the product.
Di Marzo et al (1998) Interactions between synthetic vanilloids and the endogenous cannabinoid system. FEBS Lett. 436 449 PMID: 9801167
Dray et al (1990) NE-19550 and NE-21610, antinociceptive capsaicin analogues: studies on nociceptive fibres of the neonatal rat tail in vitro. Eur.J.Pharmacol. 181 289 PMID: 2384136
Janusz et al (1993) Vanilloids. 1. Analogs of capsaicin with antinociceptive and antiinflammatory activity. J.Med.Chem. 36 2595 PMID: 8410971
Ralevic et al (2001) Cannabinoid activation of recombinant and endogenous vanilloid receptors. Eur.J.Pharmacol. 424 211 PMID: 11672565
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Keywords: Olvanil, Olvanil supplier, Potent, vanilloid, agonists, Receptors, VR1, TRPV, TRP, Channels, Transient, Receptor, Potential, NE19550, NE, 19550, 0934, Tocris Bioscience
1 Citation for Olvanil
Citations are publications that use Tocris products. Selected citations for Olvanil include:
Witte et al (2002) Use of a fluorescent imaging plate reader--based calcium assay to assess pharmacological differences between the human and rat vanilloid receptor. Am J Physiol Endocrinol Metab 7 466 PMID: 14599363
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Literature in this Area
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.