Olvanil

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Cat.No. 0934 - Olvanil | C26H43NO3 | CAS No. 58493-49-5
Description: Potent vanilloid receptor agonist
Alternative Names: NE 19550
Chemical Name: N-Vanillyloleoylamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent vanilloid receptor agonist (pEC50 values are 8.1 and 7.7 at rat and human VR1 receptors respectively). Also blocks anandamide uptake (IC50 = 9 μM) and may bind to CB1 cannabinoid receptors. Antinociceptive following systemic administration. Also available as part of the Vanilloid TRPV1 Receptor Tocriset™.

Compound Libraries

Olvanil is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 417.63
Formula C26H43NO3
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 58493-49-5
PubChem ID 5311093
InChI Key OPZKBPQVWDSATI-KHPPLWFESA-N
Smiles CCCCCCCC\C=C/CCCCCCCC(=O)NCC1=CC=C(O)C(OC)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO and to 25 mM in ethanol

Preparing Stock Solutions

The following data is based on the product molecular weight 417.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.39 mL 11.97 mL 23.94 mL
5 mM 0.48 mL 2.39 mL 4.79 mL
10 mM 0.24 mL 1.2 mL 2.39 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Di Marzo et al (1998) Interactions between synthetic vanilloids and the endogenous cannabinoid system. FEBS Lett. 436 449 PMID: 9801167

Dray et al (1990) NE-19550 and NE-21610, antinociceptive capsaicin analogues: studies on nociceptive fibres of the neonatal rat tail in vitro. Eur.J.Pharmacol. 181 289 PMID: 2384136

Janusz et al (1993) Vanilloids. 1. Analogs of capsaicin with antinociceptive and antiinflammatory activity. J.Med.Chem. 36 2595 PMID: 8410971

Ralevic et al (2001) Cannabinoid activation of recombinant and endogenous vanilloid receptors. Eur.J.Pharmacol. 424 211 PMID: 11672565


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Keywords: Olvanil, supplier, Potent, vanilloid, agonists, Receptors, VR1, TRPV, TRP, Channels, Transient, Receptor, Potential, NE19550, NE, 19550, TRPV, TRPV, Tocris Bioscience

1 Citation for Olvanil

Citations are publications that use Tocris products. Selected citations for Olvanil include:

Witte et al (2002) Use of a fluorescent imaging plate reader--based calcium assay to assess pharmacological differences between the human and rat vanilloid receptor. Am J Physiol Endocrinol Metab 7 466 PMID: 14599363


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Literature in this Area

Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

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