Valerenic acid

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Cat.No. 3048 - Valerenic acid | C15H22O2 | CAS No. 3569-10-6
Description: Positive allosteric modulator of GABAA receptors
Chemical Name: (2E)-3-[(4S,7R,7aR)-2,4,5,6,7,7a-Hexadydro-3,7-dimethyl-1H-inden-4-yl]-2-methyl-2-propenoic acid
Purity: ≥99% (HPLC)

Biological Activity

Positive allosteric modulator of GABAA receptors that displays preference for receptors containing β2 or β3 subunits. Directly activates the receptor and blocks the channel at high concentrations. Displays sedative, anticonvulsant and anxiolytic activity in vivo. Also acts as a partial  agonist of 5-HT5A receptors.

Technical Data

M. Wt 234.33
Formula C15H22O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 3569-10-6
PubChem ID 6440940
Smiles C[C@@H]2CC[C@@H](/C=C(C(O)=O)\C)C1=C(C)CC[C@@]12[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in ethanol

Preparing Stock Solutions

The following data is based on the product molecular weight 234.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.27 mL 21.34 mL 42.67 mL
5 mM 0.85 mL 4.27 mL 8.53 mL
10 mM 0.43 mL 2.13 mL 4.27 mL
50 mM 0.09 mL 0.43 mL 0.85 mL

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Product Datasheets

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References are publications that support the products' biological activity.

Dietz et al (2005) Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. Brain Res.Mol.Brain Res. 138 191 PMID: 15921820

Benke et al (2008) GABAA receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts. Neuropharmacology 56 174 PMID: 18602406

Khom et al (2007) Valerenic acid potentiates and inhibits GABAA receptors: molecular mechanism and subunit specificity. Neuropharmacol. 53 178 PMID: 17585957

Khom et al (2016) Analysis of β-subunit-dependent GABAA receptor modulation and behavioral effects of valerenic acid derivatives. J.Pharmacol.Exp.Ther. 357 580 PMID: 27190170

If you know of a relevant reference for Valerenic acid, please let us know.

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Keywords: Valerenic acid, supplier, Positive, allosteric, modulators, GABAA, receptors, Receptors, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience

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