Valerenic acid

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Cat.No. 3048 - Valerenic acid | C15H22O2 | CAS No. 3569-10-6
Description: Positive allosteric modulator of GABAA receptors
Chemical Name: (2E)-3-[(4S,7R,7aR)-2,4,5,6,7,7a-Hexadydro-3,7-dimethyl-1H-inden-4-yl]-2-methyl-2-propenoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (7)

Biological Activity

Positive allosteric modulator of GABAA receptors that displays preference for receptors containing β2 or β3 subunits. Directly activates the receptor and blocks the channel at high concentrations. Displays sedative, anticonvulsant and anxiolytic activity in vivo. Also acts as a partial agonist of 5-HT5A receptors.

Technical Data

M. Wt 234.33
Formula C15H22O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 3569-10-6
PubChem ID 6440940
InChI Key FEBNTWHYQKGEIQ-SUKRRCERSA-N
Smiles C[C@@H]2CC[C@@H](/C=C(C(O)=O)\C)C1=C(C)CC[C@@]12[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble in ethanol

References

References are publications that support the biological activity of the product.

Dietz et al (2005) Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. Brain Res.Mol.Brain Res. 138 191 PMID: 15921820

Benke et al (2008) GABAA receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts. Neuropharmacology 56 174 PMID: 18602406

Khom et al (2007) Valerenic acid potentiates and inhibits GABAA receptors: molecular mechanism and subunit specificity. Neuropharmacol. 53 178 PMID: 17585957

Khom et al (2016) Analysis of β-subunit-dependent GABAA receptor modulation and behavioral effects of valerenic acid derivatives. J.Pharmacol.Exp.Ther. 357 580 PMID: 27190170


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Citations for Valerenic acid

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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