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UNC 3230 is a potent and selective PIP5K1C inhibitor (IC50 = 41 nM). Exhibits selectivity for PIP5K1C over PIP5K1A, the PI 3-kinase family and a panel of other kinases. Reduces PIP2 levels and LPA-induced calcium signaling in dorsal root ganglia (DRG) neurons in vitro. Reduces nociception in mouse models of chronic pain.
UNC 3230 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 344.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.9 mL||14.52 mL||29.03 mL|
|5 mM||0.58 mL||2.9 mL||5.81 mL|
|10 mM||0.29 mL||1.45 mL||2.9 mL|
|50 mM||0.06 mL||0.29 mL||0.58 mL|
References are publications that support the biological activity of the product.
Wright et al (2014) The lipid kinase PIP5K1C regulates pain signaling and sensitization. Neuron 82 836 PMID: 24853942
If you know of a relevant reference for UNC 3230, please let us know.
Keywords: UNC 3230, UNC 3230 supplier, UNC3230, potent, selective, PIP5K1C, inhibitors, inhibits, antinociceptive, reduces, nociception, chronic, pain, phosphatidylinositol-4-phosphate, 5-kinase, type, I, gamma, Other, Kinases, 5271, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for UNC 3230 include:
Peng et al (2019) Type Iγ phosphatidylinositol phosphate kinase promotes tumor growth by facilitating Warburg effect in colorectal cancer. EBioMedicine PMID: 31105034
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