UNC 3230

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Description: Potent and selective PIP5K1C inhibitor; antinociceptive
Chemical Name: 5-[(Cyclohexylcarbonyl)amino]-2-(phenylamino)-thiazolecarboxamide
Purity: ≥99% (HPLC)
Citations (3)

Biological Activity for UNC 3230

UNC 3230 is a potent and selective PIP5K1C inhibitor (IC50 = 41 nM). Exhibits selectivity for PIP5K1C over PIP5K1A, the PI 3-kinase family and a panel of other kinases. Reduces PIP2 levels and LPA-induced calcium signaling in dorsal root ganglia (DRG) neurons in vitro. Reduces nociception in mouse models of chronic pain.

Compound Libraries for UNC 3230

UNC 3230 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for UNC 3230

M. Wt 344.43
Formula C17H20N4O2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1031602-63-7
PubChem ID 46355372
Smiles O=C(N)C1=C(NC(C2CCCCC2)=O)SC(NC3=CC=CC=C3)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for UNC 3230

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 34.44 100

Preparing Stock Solutions for UNC 3230

The following data is based on the product molecular weight 344.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.9 mL 14.52 mL 29.03 mL
5 mM 0.58 mL 2.9 mL 5.81 mL
10 mM 0.29 mL 1.45 mL 2.9 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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References for UNC 3230

References are publications that support the biological activity of the product.

Wright et al (2014) The lipid kinase PIP5K1C regulates pain signaling and sensitization. Neuron 82 836 PMID: 24853942

If you know of a relevant reference for UNC 3230, please let us know.

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Keywords: UNC 3230, UNC 3230 supplier, UNC3230, potent, selective, PIP5K1C, inhibitors, inhibits, antinociceptive, reduces, nociception, chronic, pain, phosphatidylinositol-4-phosphate, 5-kinase, type, I, gamma, Other, Kinases, 5271, Tocris Bioscience

3 Citations for UNC 3230

Citations are publications that use Tocris products. Selected citations for UNC 3230 include:

Christopher J et al (2021) Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells. PLoS Genet 17 e1009354 PMID: 33591981

Peng et al (2019) Type Iγ phosphatidylinositol phosphate kinase promotes tumor growth by facilitating Warburg effect in colorectal cancer. EBioMedicine PMID: 31105034

Ying et al (2017) INPP5E Preserves Genomic Stability through Regulation of Mitosis. Mol Cell Biol 37 PMID: 28031327

Do you know of a great paper that uses UNC 3230 from Tocris? Please let us know.

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