UNC 3230

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Cat.No. 5271 - UNC 3230 | C17H20N4O2S | CAS No. 1031602-63-7
Description: Potent and selective PIP5K1C inhibitor; antinociceptive
Chemical Name: 5-[(Cyclohexylcarbonyl)amino]-2-(phenylamino)-thiazolecarboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective PIP5K1C inhibitor (IC50 = 41 nM). Exhibits selectivity for PIP5K1C over PIP5K1A, the PI 3-kinase family and a panel of other kinases. Reduces PIP2 levels and LPA-induced calcium signaling in dorsal root ganglia (DRG) neurons in vitro. Reduces nociception in mouse models of chronic pain.

Compound Libraries

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Technical Data

M. Wt 344.43
Formula C17H20N4O2S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1031602-63-7
PubChem ID 46355372
InChI Key RZCNASHHHSKTGP-UHFFFAOYSA-N
Smiles O=C(N)C1=C(NC(C2CCCCC2)=O)SC(NC3=CC=CC=C3)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 344.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.9 mL 14.52 mL 29.03 mL
5 mM 0.58 mL 2.9 mL 5.81 mL
10 mM 0.29 mL 1.45 mL 2.9 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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References

References are publications that support the biological activity of the product.

Wright et al (2014) The lipid kinase PIP5K1C regulates pain signaling and sensitization. Neuron 82 836 PMID: 24853942


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Citations for UNC 3230

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