UK 59811 hydrochloride

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Cat.No. 6179 - UK 59811 hydrochloride | C22H29BrN2O5.HCl
Description: CaVAb blocker
Chemical Name: 3-Ethyl 5-methyl 4-(2-bromophenyl)-2-((2-(dimethylamino)ethoxy)methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Blocks CaVAb, a site-directed mutant of bacterial NaVAb with full voltage-dependent Ca2+ channel function (IC50 = 194 nM).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 517.84
Formula C22H29BrN2O5.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
Smiles CCOC(C1=C(NC(C)=C(C(OC)=O)C1C2=CC=CC=C2Br)COCCN(C)C)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 10.36 20
DMSO 51.78 100

Preparing Stock Solutions

The following data is based on the product molecular weight 517.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.93 mL 9.66 mL 19.31 mL
5 mM 0.39 mL 1.93 mL 3.86 mL
10 mM 0.19 mL 0.97 mL 1.93 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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References

References are publications that support the biological activity of the product.

Tang et al (2016) Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs. Nature 537 117 PMID: 27556947


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View all Voltage-gated Calcium Channel (CaV) Blockers

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Citations for UK 59811 hydrochloride

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