UK 59811 hydrochloride

Discontinued Product

UK 59811 hydrochloride (Cat. No. 6179) has been withdrawn from sale for commercial reasons.
Description: CaVAb blocker
Chemical Name: 3-Ethyl 5-methyl 4-(2-bromophenyl)-2-((2-(dimethylamino)ethoxy)methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for UK 59811 hydrochloride

UK 59811 hydrochloride is a blocks CaVAb, a site-directed mutant of bacterial NaVAb with full voltage-dependent Ca2+ channel function (IC50 = 194 nM).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for UK 59811 hydrochloride

M. Wt 517.84
Formula C22H29BrN2O5.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 2250025-89-7
PubChem ID 134812832
InChI Key JZOQTVYILXBAMQ-UHFFFAOYSA-N
Smiles CCOC(C1=C(NC(C)=C(C(OC)=O)C1C2=CC=CC=C2Br)COCCN(C)C)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for UK 59811 hydrochloride

References for UK 59811 hydrochloride

References are publications that support the biological activity of the product.

Tang et al (2016) Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs. Nature 537 117 PMID: 27556947

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Citations for UK 59811 hydrochloride

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Currently there are no citations for UK 59811 hydrochloride.

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