UK 59811 hydrochloride

Pricing Availability   Qty
Description: CaVAb blocker
Chemical Name: 3-Ethyl 5-methyl 4-(2-bromophenyl)-2-((2-(dimethylamino)ethoxy)methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
Purity: ≥98% (HPLC)

Biological Activity for UK 59811 hydrochloride

UK 59811 hydrochloride is a blocks CaVAb, a site-directed mutant of bacterial NaVAb with full voltage-dependent Ca2+ channel function (IC50 = 194 nM).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for UK 59811 hydrochloride

M. Wt 517.84
Formula C22H29BrN2O5.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
PubChem ID 134812832
Smiles CCOC(C1=C(NC(C)=C(C(OC)=O)C1C2=CC=CC=C2Br)COCCN(C)C)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for UK 59811 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 10.36 20
DMSO 51.78 100

Preparing Stock Solutions for UK 59811 hydrochloride

The following data is based on the product molecular weight 517.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.93 mL 9.66 mL 19.31 mL
5 mM 0.39 mL 1.93 mL 3.86 mL
10 mM 0.19 mL 0.97 mL 1.93 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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Product Datasheets for UK 59811 hydrochloride

References for UK 59811 hydrochloride

References are publications that support the biological activity of the product.

Tang et al (2016) Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs. Nature 537 117 PMID: 27556947

If you know of a relevant reference for UK 59811 hydrochloride, please let us know.

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Citations for UK 59811 hydrochloride

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