Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewUK 59811 hydrochloride
Description: CaVAb blocker
Chemical Name: 3-Ethyl 5-methyl 4-(2-bromophenyl)-2-((2-(dimethylamino)ethoxy)methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for UK 59811 hydrochloride
UK 59811 hydrochloride is a blocks CaVAb, a site-directed mutant of bacterial NaVAb with full voltage-dependent Ca2+ channel function (IC50 = 194 nM).
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for UK 59811 hydrochloride
| M. Wt | 517.84 |
| Formula | C22H29BrN2O5.HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 134812832 |
| InChI Key | JZOQTVYILXBAMQ-UHFFFAOYSA-N |
| Smiles | CCOC(C1=C(NC(C)=C(C(OC)=O)C1C2=CC=CC=C2Br)COCCN(C)C)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for UK 59811 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 10.36 | 20 | |
| DMSO | 51.78 | 100 |
Preparing Stock Solutions for UK 59811 hydrochloride
The following data is based on the product molecular weight 517.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.93 mL | 9.66 mL | 19.31 mL |
| 5 mM | 0.39 mL | 1.93 mL | 3.86 mL |
| 10 mM | 0.19 mL | 0.97 mL | 1.93 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.39 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for UK 59811 hydrochloride
References for UK 59811 hydrochloride
References are publications that support the biological activity of the product.
Tang et al (2016) Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs. Nature 537 117 PMID: 27556947
If you know of a relevant reference for UK 59811 hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: UK 59811 hydrochloride, UK 59811 hydrochloride supplier, UK59811, HCl, hydrochloride, voltage-gated, calcium, channels, blockers, blocks, inhibits, inhibitors, CavAb, Ca2+, 102672-02-6, NavAb, Non-selective, Cav, Channels, Voltage-gated, Sodium, 6179, Tocris Bioscience
Citations for UK 59811 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for UK 59811 hydrochloride. Do you know of a great paper that uses UK 59811 hydrochloride from Tocris? Please let us know.
Reviews for UK 59811 hydrochloride
There are currently no reviews for this product. Be the first to review UK 59811 hydrochloride and earn rewards!
Have you used UK 59811 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image