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Submit ReviewUK 59811 hydrochloride is a blocks CaVAb, a site-directed mutant of bacterial NaVAb with full voltage-dependent Ca2+ channel function (IC50 = 194 nM).
Sold for research purposes under agreement from Pfizer Inc.
M. Wt | 517.84 |
Formula | C22H29BrN2O5.HCl |
Storage | Store at +4°C |
Purity | ≥98% (HPLC) |
PubChem ID | 134812832 |
InChI Key | JZOQTVYILXBAMQ-UHFFFAOYSA-N |
Smiles | CCOC(C1=C(NC(C)=C(C(OC)=O)C1C2=CC=CC=C2Br)COCCN(C)C)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
water | 10.36 | 20 | |
DMSO | 51.78 | 100 |
The following data is based on the product molecular weight 517.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.93 mL | 9.66 mL | 19.31 mL |
5 mM | 0.39 mL | 1.93 mL | 3.86 mL |
10 mM | 0.19 mL | 0.97 mL | 1.93 mL |
50 mM | 0.04 mL | 0.19 mL | 0.39 mL |
References are publications that support the biological activity of the product.
Tang et al (2016) Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs. Nature 537 117 PMID: 27556947
If you know of a relevant reference for UK 59811 hydrochloride, please let us know.
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