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Submit ReviewUK 59811 hydrochloride
Discontinued Product
UK 59811 hydrochloride (Cat. No. 6179) has been withdrawn from sale for commercial reasons.
Description: CaVAb blocker
Chemical Name: 3-Ethyl 5-methyl 4-(2-bromophenyl)-2-((2-(dimethylamino)ethoxy)methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for UK 59811 hydrochloride
UK 59811 hydrochloride is a blocks CaVAb, a site-directed mutant of bacterial NaVAb with full voltage-dependent Ca2+ channel function (IC50 = 194 nM).
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for UK 59811 hydrochloride
| M. Wt | 517.84 |
| Formula | C22H29BrN2O5.HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2250025-89-7 |
| PubChem ID | 134812832 |
| InChI Key | JZOQTVYILXBAMQ-UHFFFAOYSA-N |
| Smiles | CCOC(C1=C(NC(C)=C(C(OC)=O)C1C2=CC=CC=C2Br)COCCN(C)C)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for UK 59811 hydrochloride
References for UK 59811 hydrochloride
References are publications that support the biological activity of the product.
Tang et al (2016) Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs. Nature 537 117 PMID: 27556947
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