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Submit ReviewU 90042
Description: GABAA ligand
Chemical Name: 11-Chloro-5-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-2,3-dihydrodiimidazo[1,5-a:1',2'-c]quinazoline
Purity: ≥99% (HPLC)
Biological Activity for U 90042
U 90042 is a GABAA receptor ligand that binds with comparable affinities to three receptor subtypes: α1β2γ2, α3β2γ2 and α6β2γ2 (Ki values are 7.8, 9.5 and 11.0 nM respectively). Potentiates GABA-induced chloride currents in α6β2γ2 receptors. Sedative/hypnotic compound.
Technical Data for U 90042
| M. Wt | 352.78 |
| Formula | C17H13ClN6O |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 134516-99-7 |
| PubChem ID | 9928470 |
| InChI Key | CLPSAAPUJUVQPP-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C4C(C2=NCCN2C(N4C=N5)=C5C3=NOC(C6CC6)=N3)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for U 90042
References for U 90042
References are publications that support the biological activity of the product.
Tang et al (1995) U-90042, a sedative/hypnotic compound that interacts differentially with the GABAA receptor subtypes. J.Pharmacol.Exp.Ther. 275 761 PMID: 7473164
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Keywords: U 90042, U 90042 supplier, GABAA, receptor, ligands, Receptors, U90042, 2733, Tocris Bioscience
Citations for U 90042
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.