U 90042

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Cat.No. 2733 - U 90042 | C17H13ClN6O | CAS No. 134516-99-7
Description: GABAA receptor ligand
Chemical Name: 11-Chloro-5-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-2,3-dihydrodiimidazo[1,5-a:1',2'-c]quinazoline
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

GABAA receptor ligand that binds with comparable affinities to three receptor subtypes: α1β2γ2, α3β2γ2 and α6β2γ2 (Ki values are 7.8, 9.5 and 11.0 nM respectively). Potentiates GABA-induced chloride currents in α6β2γ2 receptors. Sedative/hypnotic compound.

Technical Data

M. Wt 352.78
Formula C17H13ClN6O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 134516-99-7
PubChem ID 9928470
InChI Key CLPSAAPUJUVQPP-UHFFFAOYSA-N
Smiles ClC1=CC=C4C(C2=NCCN2C(N4C=N5)=C5C3=NOC(C6CC6)=N3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.58 30
ethanol 1.76 5

Preparing Stock Solutions

The following data is based on the product molecular weight 352.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.17 mL 28.35 mL
5 mM 0.57 mL 2.83 mL 5.67 mL
10 mM 0.28 mL 1.42 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Tang et al (1995) U-90042, a sedative/hypnotic compound that interacts differentially with the GABAA receptor subtypes. J.Pharmacol.Exp.Ther. 275 761 PMID: 7473164


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Keywords: GABAA receptor ligands Receptors U90042 GABAA Receptors

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