U 89843A

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Cat.No. 2734 - U 89843A | C16H23N5.HCl | CAS No. 157013-85-9
Description: Positive allosteric modulator of GABAA receptors
Alternative Names: PNU 89843
Chemical Name: 6,7-Dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Positive allosteric modulator of GABAA receptors. Enhances GABA-induced Cl- currents in the α1β2γ2, α3β2γ2 and α6β2γ2 subtypes. Causes sedation in vivo following i.v. administration without losing "righting reflex". Also displays antioxidant activity.

Technical Data

M. Wt 321.85
Formula C16H23N5.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 157013-85-9
PubChem ID 56972182
InChI Key MNKBXPNQWKUSKU-UHFFFAOYSA-N
Smiles CC2=CC1=C(N3CCCC3)N=C(N4CCCC4)N=C1N2C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 8.05 25
DMSO 16.09 50

Preparing Stock Solutions

The following data is based on the product molecular weight 321.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.11 mL 15.54 mL 31.07 mL
5 mM 0.62 mL 3.11 mL 6.21 mL
10 mM 0.31 mL 1.55 mL 3.11 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Bundy et al (1995) Synthesis of novel 2,4-diaminopyrrolo-[2,3-d]pyrimidines with antioxidant, neuroprotective, and antiasthma activity. J.Med.Chem. 38 4161 PMID: 7473542

Haesook et al (1995) U-89843A is a novel allosteric modulator of γ-aminobutyric acidA receptors. J.Pharmacol.Exp.Ther. 275 1390 PMID: 8531107

Rohn et al (1996) Inhibition of Ca2+-pump ATPase and the Na+/K+-pump ATPase by iron-generated free radicals. Biochem.Pharmacol. 51 471 PMID: 8619892


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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