TRAM 1

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Description: Chemical inducer of proximity for dTAG protein FKBPF36V and ecDHFR tags
Chemical Name: (R)-1-(3-(2-((3-(4-((2,4-Diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)propyl)amino)-2-oxoethoxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for TRAM 1

TRAM 1 is a targeted relocalization activating molecule (TRAM) and chemical inducer of proximity for the dTAG protein FKBP12F36V and ecDHFR tags. Can be used to shuttle and redistribute proteins in live cells.

Technical Data for TRAM 1

M. Wt 1009.17
Formula C54H68N6O13
Storage Store at -20°C
Purity ≥98% (HPLC)
InChI Key SGECTVFBOKCZAI-YZBUDRBASA-N
Smiles O=C(O[C@H](CCC1=CC(OC)=C(C=C1)OC)C2=CC(OCC(NCCCOC3=C(C=C(C=C3OC)CC4=CN=C(N=C4N)N)OC)=O)=CC=C2)[C@@H]5CCCCN5C([C@@H](CC)C6=CC(OC)=C(C(OC)=C6)OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TRAM 1

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100.92 100

Preparing Stock Solutions for TRAM 1

The following data is based on the product molecular weight 1009.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.99 mL 4.95 mL 9.91 mL
5 mM 0.2 mL 0.99 mL 1.98 mL
10 mM 0.1 mL 0.5 mL 0.99 mL
50 mM 0.02 mL 0.1 mL 0.2 mL

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References for TRAM 1

References are publications that support the biological activity of the product.

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Keywords: TRAM 1, TRAM 1 supplier, TRAM1, targeted, relocalization, activation, molecules, dTAG, FKBP12, FKBP12F36V, cereblon, degrade, degrader, degradation, dhfr, tag, degron, chemical, inducer, of, proximity, Protein, Dimerizers, 8121, Tocris Bioscience

Citations for TRAM 1

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