Tracazolate hydrochloride

Pricing Availability   Qty
Description: Allosteric modulator of GABAA receptors
Alternative Names: ICI 136753
Chemical Name: 4-(Butylamino)-1-ethyl-6-methyl 1H-pyrazolo[3,4b]pyridine-5-ethylcarboxylate hydrochloride
Purity: ≥99% (HPLC)
Citations (1)
Literature (2)

Biological Activity for Tracazolate hydrochloride

Tracazolate hydrochloride is a GABAA receptor modulator. Can potentiate or inhibit recombinant GABAA function depending on subunit combination. Enhances native GABAA receptor function and is anxiolytic following systemic administration in vivo.

Technical Data for Tracazolate hydrochloride

M. Wt 340.85
Formula C16H24N4O2.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1135210-68-2
PubChem ID 24871267

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Tracazolate hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
1eq. HCl 34.09 100

Preparing Stock Solutions for Tracazolate hydrochloride

The following data is based on the product molecular weight 340.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.93 mL 14.67 mL 29.34 mL
5 mM 0.59 mL 2.93 mL 5.87 mL
10 mM 0.29 mL 1.47 mL 2.93 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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Product Datasheets for Tracazolate hydrochloride

References for Tracazolate hydrochloride

References are publications that support the biological activity of the product.

Meiners and Salama (1982) Enhancement of benzodiazepine and GABA binding by the novel anxiolytic, tracazolate. Eur.J.Pharmacol. 78 315 PMID: 6121710

Patel and Malick (1982) Pharmacological properties of tracazolate: a new non-benzodiazepine anxiolytic agent. Eur.J.Pharmacol. 78 323 PMID: 6121711

Thompson et al (2002) Tracazolate reveals a novel type of allosteric interaction with recombinant γ-aminobutyric acidA receptors. Mol.Pharmacol. 61 861 PMID: 11901225

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Keywords: Tracazolate hydrochloride, Tracazolate hydrochloride supplier, Subtype-selective, GABAA, allosteric, modulators, Receptors, ICI136753, ICI, 136753, 1558, Tocris Bioscience

1 Citation for Tracazolate hydrochloride

Citations are publications that use Tocris products. Selected citations for Tracazolate hydrochloride include:

Kerti-Szigeti et al (2014) Synaptic GABAA receptor clustering without the γ2 subunit. J Neurosci 34 10219 PMID: 25080584

Do you know of a great paper that uses Tracazolate hydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.