Subtype-selective GABAA receptor modulator. Can potentiate or inhibit recombinant GABAA function depending on subunit combination. Enhances native GABAA receptor function and is anxiolytic following systemic administration in vivo.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 340.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.93 mL||14.67 mL||29.34 mL|
|5 mM||0.59 mL||2.93 mL||5.87 mL|
|10 mM||0.29 mL||1.47 mL||2.93 mL|
|50 mM||0.06 mL||0.29 mL||0.59 mL|
References are publications that support the products' biological activity.
Meiners and Salama (1982) Enhancement of benzodiazepine and GABA binding by the novel anxiolytic, tracazolate. Eur.J.Pharmacol. 78 315 PMID: 6121710
Patel and Malick (1982) Pharmacological properties of tracazolate: a new non-benzodiazepine anxiolytic agent. Eur.J.Pharmacol. 78 323 PMID: 6121711
Thompson et al (2002) Tracazolate reveals a novel type of allosteric interaction with recombinant γ-aminobutyric acidA receptors. Mol.Pharmacol. 61 861 PMID: 11901225
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Keywords: Tracazolate hydrochloride, supplier, Subtype-selective, GABAA, allosteric, modulators, Receptors, ICI136753, ICI, 136753, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience
1 Citation for Tracazolate hydrochloride
Citations are publications that use Tocris products. Selected citations for Tracazolate hydrochloride include:
Kerti-Szigeti et al (2014) Synaptic GABAA receptor clustering without the γ2 subunit. J Neurosci 34 10219 PMID: 25080584
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Tracazolate hydrochloride Reviews
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