TP 238

Pricing Availability   Qty
Description: CECR2 and BPTF/FALZ inhibitor
Chemical Name: N-[(3-(1H)-Pyrazol-1-yl)propyl)-6-(4-(3-(dimethylamino)propoxy)phenyl)-2-(methylsulfonyl)pyrimidin-4-amine hydrochloride
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity for TP 238

TP 238 is a cat eye syndrome chromosome region, candidate 2 (CECR2) and bromodomain PHD finger transcription factor (BPTF/FALZ) inhibitor (IC50 values are 10-30 and 100-350 nM, respectively).

A concentration of no more than 2 μM is recommended for use in cellular assays.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the TP 238 probe summary on the SGC website.

Compound Libraries for TP 238

TP 238 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for TP 238

M. Wt 495.04
Formula C22H30N6O<sub>3S.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2415263-05-5
Smiles O=S(C1=NC(NCCCN2N=CC=C2)=CC(C3=CC=C(C=C3)OCCCN(C)C)=N1)(C)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TP 238

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 49.5 100
water 49.5 100

Preparing Stock Solutions for TP 238

The following data is based on the product molecular weight 495.04. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.02 mL 10.1 mL 20.2 mL
5 mM 0.4 mL 2.02 mL 4.04 mL
10 mM 0.2 mL 1.01 mL 2.02 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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References for TP 238

References are publications that support the biological activity of the product.

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Keywords: TP 238, TP 238 supplier, TP238, bromodomain, inhibitors, inhibits, Cat, eye, syndrome, chromosome, region,, candidate, 2, CECR2, PHD, finger, transcription, factor, BPTF, FALZ, Bromodomains, 6670, Tocris Bioscience

Citations for TP 238

Citations are publications that use Tocris products.

Currently there are no citations for TP 238. Do you know of a great paper that uses TP 238 from Tocris? Please let us know.

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