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TP 238

Cat. No. 6670 Submit a Review Datasheet / COA / SDS
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Cat.No. 6670 - TP 238 | C22H30N6O3S.HCl
Description: CECR2 and BPTF/FALZ inhibitor
Chemical Name: N-[(3-(1H)-Pyrazol-1-yl)propyl)-6-(4-(3-(dimethylamino)propoxy)phenyl)-2-(methylsulfonyl)pyrimidin-4-amine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Cat eye syndrome chromosome region, candidate 2 (CECR2) and bromodomain PHD finger transcription factor (BPTF/FALZ) inhibitor (IC50 values are 10-30 and 100-350 nM, respectively).

A concentration of no more than 2 μM is recommended for use in cellular assays.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the TP 238 probe summary on the SGC website.

Technical Data

M. Wt 495.04
Formula C22H30N6O<sub>3S.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
Smiles O=S(C1=NC(NCCCN2N=CC=C2)=CC(C3=CC=C(C=C3)OCCCN(C)C)=N1)(C)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.5 100
water 49.5 100

Preparing Stock Solutions

The following data is based on the product molecular weight 495.04. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.02 mL 10.1 mL 20.2 mL
5 mM 0.4 mL 2.02 mL 4.04 mL
10 mM 0.2 mL 1.01 mL 2.02 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

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Citations for TP 238

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Literature in this Area

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