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Submit ReviewTP 238
Description: CECR2 and BPTF/FALZ inhibitor
Chemical Name: N-[(3-(1H)-Pyrazol-1-yl)propyl)-6-(4-(3-(dimethylamino)propoxy)phenyl)-2-(methylsulfonyl)pyrimidin-4-amine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for TP 238
TP 238 is a cat eye syndrome chromosome region, candidate 2 (CECR2) and bromodomain PHD finger transcription factor (BPTF/FALZ) inhibitor (IC50 values are 10-30 and 100-350 nM, respectively).
A concentration of no more than 2 μM is recommended for use in cellular assays.
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the TP 238 probe summary on the SGC website.
Compound Libraries for TP 238
TP 238 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.
Technical Data for TP 238
| M. Wt | 495.04 |
| Formula | C22H30N6O<sub>3S.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2415263-05-5 |
| Smiles | O=S(C1=NC(NCCCN2N=CC=C2)=CC(C3=CC=C(C=C3)OCCCN(C)C)=N1)(C)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TP 238
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.5 | 100 | |
| water | 49.5 | 100 |
Preparing Stock Solutions for TP 238
The following data is based on the product molecular weight 495.04. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.02 mL | 10.1 mL | 20.2 mL |
| 5 mM | 0.4 mL | 2.02 mL | 4.04 mL |
| 10 mM | 0.2 mL | 1.01 mL | 2.02 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
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References for TP 238
References are publications that support the biological activity of the product.
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Keywords: TP 238, TP 238 supplier, TP238, bromodomain, inhibitors, inhibits, Cat, eye, syndrome, chromosome, region,, candidate, 2, CECR2, PHD, finger, transcription, factor, BPTF, FALZ, Bromodomains, 6670, Tocris Bioscience
Citations for TP 238
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