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Cat.No. 6555 - TokeOni | C16H18N2O2S.HCl
Description: NIR-emission luciferin analog; orally bioavailable and brain penetrant
Alternative Names: AkaLumine HCl
Chemical Name: (4S)-2-[(1E,3E)-4-[4-(Dimethylamino)phenyl]-1,3-butadien-1-yl]-4,5-dihydro-4-thiazolecarboxylic acid hydrochloride
Purity: ≥90% (HPLC)

Biological Activity

Near-infrared red (NIR)-emission luciferin analog. Peak luminescence at 677 nM. ~40-fold brighter than luciferase. 100-1000 times brighter in vivo than conventional systems. Allows non-invasive visualization of single cells deep inside freely moving animals. Orally bioavailable and brain penetrant.

The batch molecular weight of the product may vary significantly due to hydration level. Please refer to the Certificate of Analysis for the current batch.

Technical Data

M. Wt 338.85
Formula C16H18N2O2S.HCl
Storage Store at -20°C
Purity ≥90% (HPLC)
PubChem ID 124203055
Smiles CN(C1=CC=C(C=C1)/C=C/C=C/C2=N[C@@H](C(O)=O)CS2)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 5 15 with gentle warming
DMSO 10 30

Preparing Stock Solutions

The following data is based on the product molecular weight 338.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.3 mM 9.84 mL 49.19 mL 98.37 mL
1.5 mM 1.97 mL 9.84 mL 19.67 mL
3 mM 0.98 mL 4.92 mL 9.84 mL
15 mM 0.2 mL 0.98 mL 1.97 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Kuchimaru et al (2016) A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging. Nat. Commun. 7 11856 PMID: 27297211

Nasu et al (2018) Unnaturally aglow with a bright inner light. Science 359 868 PMID: 29472468

Iwano et al (2018) Single-cell bioluminescence imaging of deep tissue in freely moving animals. Science 359 935 PMID: 29472486

If you know of a relevant reference for TokeOni, please let us know.

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