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Biological Activity for TokeOni
TokeOni is a near-infrared red (NIR)-emission luciferin analog. Peak luminescence at 677 nM. ~40-fold brighter than the luciferin-luciferase system in vitro, and 100-1000 times brighter in vivo. Allows non-invasive visualization of single cells deep inside freely moving animals. Ideal for deep tissue applications. Water soluble (<40 mM), orally bioavailable and brain penetrant.
This product is supplied as a hydrochloride salt, the stoichiometry of which is batch dependant. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content.
Optical Data for TokeOni
Technical Data for TokeOni
|M. Wt||302.39 (Free Base)|
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TokeOni
|Solubility||Soluble to 5 mg/ml in water with gentle warming and to 10 mg/ml in DMSO|
References for TokeOni
References are publications that support the biological activity of the product.
Kuchimaru et al (2016) A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging. Nat. Commun. 7 11856 PMID: 27297211
Nasu et al (2018) Unnaturally aglow with a bright inner light. Science 359 868 PMID: 29472468
Iwano et al (2018) Single-cell bioluminescence imaging of deep tissue in freely moving animals. Science 359 935 PMID: 29472486
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