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Description: NIR-emission luciferin analog; ideal for deep tissue applications; orally bioavailable and brain penetrant
Alternative Names: AkaLumine HCl
Chemical Name: (4S)-2-[(1E,3E)-4-[4-(Dimethylamino)phenyl]-1,3-butadien-1-yl]-4,5-dihydro-4-thiazolecarboxylic acid hydrochloride
Purity: ≥90% (HPLC)
Citations (1)
Literature (1)

Biological Activity for TokeOni

TokeOni is a near-infrared red (NIR)-emission luciferin analog. Peak luminescence at 677 nM. ~40-fold brighter than the luciferin-luciferase system in vitro, and 100-1000 times brighter in vivo. Allows non-invasive visualization of single cells deep inside freely moving animals. Ideal for deep tissue applications. Water soluble (<40 mM), orally bioavailable and brain penetrant.

This product is supplied as a hydrochloride salt, the stoichiometry of which is batch dependant. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content.

Optical Data for TokeOni

TokeOni Dye Spectra
Emission Color Near-IR
λem 677 nm
Application BLI, BTI, Deep Tissue Applications

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Technical Data for TokeOni

M. Wt 302.39 (Free Base)
Formula C16H18N2O2S.xHCl
Storage Store at -20°C
Purity ≥90% (HPLC)
PubChem ID 124203055
Smiles CN(C1=CC=C(C=C1)/C=C/C=C/C2=N[C@@H](C(O)=O)CS2)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TokeOni

Solubility Soluble to 5 mg/ml in water with gentle warming and to 10 mg/ml in DMSO

Product Datasheets for TokeOni

Certificate of Analysis / Product Datasheet
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References for TokeOni

References are publications that support the biological activity of the product.

Kuchimaru et al (2016) A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging. Nat. Commun. 7 11856 PMID: 27297211

Nasu et al (2018) Unnaturally aglow with a bright inner light. Science 359 868 PMID: 29472468

Iwano et al (2018) Single-cell bioluminescence imaging of deep tissue in freely moving animals. Science 359 935 PMID: 29472486

If you know of a relevant reference for TokeOni, please let us know.

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1 Citation for TokeOni

Citations are publications that use Tocris products. Selected citations for TokeOni include:

Vivien et al (2022) Firefly luciferase offers superior performance to AkaLuc for tracking the fate of administered cell therapies. Eur J Nucl Med Mol Imaging 49 796-808 PMID: 34313817

Do you know of a great paper that uses TokeOni from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Fluorescent Dyes and Probes Research Product Guide

Fluorescent Dyes and Probes Research Product Guide

This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:

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  • Tissue Clearing Kits and Reagents
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