TokeOni

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Cat.No. 6555 - TokeOni | C16H18N2O2S.xHCl
Description: NIR-emission luciferin analog; ideal for deep tissue applications; orally bioavailable and brain penetrant
Alternative Names: AkaLumine HCl
Chemical Name: (4S)-2-[(1E,3E)-4-[4-(Dimethylamino)phenyl]-1,3-butadien-1-yl]-4,5-dihydro-4-thiazolecarboxylic acid hydrochloride
Purity: ≥90% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Near-infrared red (NIR)-emission luciferin analog. Peak luminescence at 677 nM. ~40-fold brighter than the luciferin-luciferase system in vitro, and 100-1000 times brighter in vivo. Allows non-invasive visualization of single cells deep inside freely moving animals. Ideal for deep tissue applications. Water soluble (<40 mM), orally bioavailable and brain penetrant.

This product is supplied as a hydrochloride salt, the stoichiometry of which is batch dependant. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content.

Optical Data for TokeOni

TokeOni Dye Spectra
Emission Color Near-IR
λem 677 nm
Application BLI, BTI, Deep tissue applications

Technical Data

M. Wt 302.39 (Free Base)
Formula C16H18N2O2S.xHCl
Storage Store at -20°C
Purity ≥90% (HPLC)
PubChem ID 124203055
InChI Key PZCNKVAGZCXXHX-SSRSOBHISA-N
Smiles CN(C1=CC=C(C=C1)/C=C/C=C/C2=N[C@@H](C(O)=O)CS2)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 5 INF with gentle warming
DMSO 10 INF

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Kuchimaru et al (2016) A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging. Nat. Commun. 7 11856 PMID: 27297211

Nasu et al (2018) Unnaturally aglow with a bright inner light. Science 359 868 PMID: 29472468

Iwano et al (2018) Single-cell bioluminescence imaging of deep tissue in freely moving animals. Science 359 935 PMID: 29472486


If you know of a relevant reference for TokeOni, please let us know.

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Citations for TokeOni

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Literature in this Area

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