TL 13-27

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Cat.No. 6525 - TL 13-27 | C44H53ClN10O8S | CAS No. 2250025-90-0
Description: Negative control for TL 12-186
Chemical Name: N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((1,3-dioxo-2-(2-oxopiperidin-3-yl)isoindolin-4-yl)amino)acetamide
Purity: ≥98% (HPLC)

Biological Activity

Negative control for TL 12-186 (Cat. No. 6524). Demonstrates no kinase degradation in vitro.

Technical Data

M. Wt 917.48
Formula C44H53ClN10O8S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2250025-90-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 91.75 100

Preparing Stock Solutions

The following data is based on the product molecular weight 917.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.09 mL 5.45 mL 10.9 mL
5 mM 0.22 mL 1.09 mL 2.18 mL
10 mM 0.11 mL 0.54 mL 1.09 mL
50 mM 0.02 mL 0.11 mL 0.22 mL

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References are publications that support the biological activity of the product.

Huang et al (2018) A chemoproteomic approach to query the degradable kinome using a multi-kinase degrader. Cell Chem.Biol. 25 88 PMID: 29129717

If you know of a relevant reference for TL 13-27, please let us know.

Keywords: TL 13-27, TL 13-27 supplier, TL13-27, PROTAC, Proteolysis, targeted, chimeras, cereblon, E3, ubiquitin, ligase, kinase, inhibitors, negative, control, PROTACs, Other, Kinases, Ubiquitin, Ligases, 6525, Tocris Bioscience

Citations for TL 13-27

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