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Biological Activity for TL 12-186
TL 12-186 is a degrader (PROTAC®) comprised of a highly promiscuous kinase inhibitor conjugated to the cereblon E3 ubiquitin ligase ligand, pomalidomide (Cat. No. 6302). Degrades a range of kinases in MOLT-4 and MOLM-14 cell lines.
Negative control TL 13-27 (Cat. No. 6525) is also available.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Technical Data for TL 12-186
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TL 12-186
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for TL 12-186
The following data is based on the product molecular weight 931.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.07 mL||5.37 mL||10.74 mL|
|5 mM||0.21 mL||1.07 mL||2.15 mL|
|10 mM||0.11 mL||0.54 mL||1.07 mL|
|50 mM||0.02 mL||0.11 mL||0.21 mL|
References for TL 12-186
References are publications that support the biological activity of the product.
Huang et al (2018) A chemoproteomic approach to query the degradable kinome using a multi-kinase degrader. Cell Chem.Biol. 25 88 PMID: 29129717
If you know of a relevant reference for TL 12-186, please let us know.
View Related Products by Target
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Citations for TL 12-186
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Currently there are no citations for TL 12-186. Do you know of a great paper that uses TL 12-186 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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