PROTAC comprised of a highly promiscuous kinase inhibitor conjugated to the cereblon E3 ubiquitin ligase ligand, pomalidomide (Cat. No. 6302). Degrades a range of kinases in MOLT-4 and MOLM-14 cell lines. Negative control TL 13-27 (Cat. No. 6525) is also available.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 931.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.07 mL||5.37 mL||10.74 mL|
|5 mM||0.21 mL||1.07 mL||2.15 mL|
|10 mM||0.11 mL||0.54 mL||1.07 mL|
|50 mM||0.02 mL||0.11 mL||0.21 mL|
References are publications that support the biological activity of the product.
Huang et al (2018) A chemoproteomic approach to query the degradable kinome using a multi-kinase degrader. Cell Chem.Biol. 25 88 PMID: 29129717
If you know of a relevant reference for TL 12-186, please let us know.
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Keywords: TL 12-186, TL 12-186 supplier, TL12-186, PROTAC, Proteolysis, targeted, chimeras, cereblon, E3, ubiquitin, ligase, kinase, inhibitors, PROTACs, Other, Kinases, Ubiquitin, Ligases, 6524, Tocris Bioscience
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