TL 12-186

Pricing Availability   Qty
Cat.No. 6524 - TL 12-186 | C44H51ClN10O9S | CAS No. 2250025-88-6
Description: Multikinase degrading PROTAC
Chemical Name: N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

PROTAC comprised of a highly promiscuous kinase inhibitor conjugated to the cereblon E3 ubiquitin ligase ligand, pomalidomide (Cat. No. 6302). Degrades a range of kinases in MOLT-4 and MOLM-14 cell lines. Negative control TL 13-27 (Cat. No. 6525) is also available.

Technical Data

M. Wt 931.46
Formula C44H51ClN10O9S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2250025-88-6
Smiles O=C1C(CCC(N1)=O)N2C(C3=C(C2=O)C=CC=C3NCC(NCCOCCOCCN4CCN(CC4)C5=CC=C(C=C5)NC6=NC(NC7=C(C=CC=C7)S(=O)(C(C)C)=O)=C(C=N6)Cl)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 93.15 100

Preparing Stock Solutions

The following data is based on the product molecular weight 931.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.07 mL 5.37 mL 10.74 mL
5 mM 0.21 mL 1.07 mL 2.15 mL
10 mM 0.11 mL 0.54 mL 1.07 mL
50 mM 0.02 mL 0.11 mL 0.21 mL

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References

References are publications that support the biological activity of the product.

Huang et al (2018) A chemoproteomic approach to query the degradable kinome using a multi-kinase degrader. Cell Chem.Biol. 25 88 PMID: 29129717


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Keywords: TL 12-186, TL 12-186 supplier, TL12-186, PROTAC, Proteolysis, targeted, chimeras, cereblon, E3, ubiquitin, ligase, kinase, inhibitors, PROTACs, Other, Kinases, Ubiquitin, Ligases, 6524, Tocris Bioscience

Citations for TL 12-186

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