TL 12-186

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Cat.No. 6524 - TL 12-186 | C44H51ClN10O9S | CAS No. 2250025-88-6
Description: Multikinase Degrader (PROTAC®)
Chemical Name: N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity for TL 12-186

TL 12-186 is a degrader (PROTAC®) comprised of a highly promiscuous kinase inhibitor conjugated to the cereblon E3 ubiquitin ligase ligand, pomalidomide (Cat. No. 6302). Degrades a range of kinases in MOLT-4 and MOLM-14 cell lines.

Negative control TL 13-27 (Cat. No. 6525) is also available.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for TL 12-186

M. Wt 931.46
Formula C44H51ClN10O9S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2250025-88-6
PubChem ID 134812843
Smiles O=C1C(CCC(N1)=O)N2C(C3=C(C2=O)C=CC=C3NCC(NCCOCCOCCN4CCN(CC4)C5=CC=C(C=C5)NC6=NC(NC7=C(C=CC=C7)S(=O)(C(C)C)=O)=C(C=N6)Cl)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TL 12-186

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 93.15 100

Preparing Stock Solutions for TL 12-186

The following data is based on the product molecular weight 931.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.07 mL 5.37 mL 10.74 mL
5 mM 0.21 mL 1.07 mL 2.15 mL
10 mM 0.11 mL 0.54 mL 1.07 mL
50 mM 0.02 mL 0.11 mL 0.21 mL

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References for TL 12-186

References are publications that support the biological activity of the product.

Huang et al (2018) A chemoproteomic approach to query the degradable kinome using a multi-kinase degrader. Cell Chem.Biol. 25 88 PMID: 29129717

If you know of a relevant reference for TL 12-186, please let us know.

Keywords: TL 12-186, TL 12-186 supplier, TL12-186, PROTAC, PROTACs, Proteolysis, targeted, chimeras, cereblon, E3, ubiquitin, ligase, kinase, protein, degradation, tpd, active, degraders, degrades, Active, Degraders, Other, Kinases, 6524, Tocris Bioscience

Citations for TL 12-186

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Currently there are no citations for TL 12-186. Do you know of a great paper that uses TL 12-186 from Tocris? Please let us know.

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Literature in this Area

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