Tiagabine hydrochloride

Pricing Availability   Qty
Description: Selective GAT-1 inhibitor; anticonvulsant
Chemical Name: (3R)-1-[4,4-Bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid hydrochloride
Purity: ≥99% (HPLC)
Citations (2)
Literature (2)

Biological Activity for Tiagabine hydrochloride

Tiagabine hydrochloride is a GABA uptake inhibitor (IC50 = 67 nM in vivo). Exhibits high affinity and selectivity for the GAT-1 GABA transporter. Anticonvulsant; also attenuates established dynorphin-induced allodynia in a mouse model after systemic administration.

Compound Libraries for Tiagabine hydrochloride

Tiagabine hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Tiagabine hydrochloride

M. Wt 412.01
Formula C20H25NO2S2.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 145821-59-6
PubChem ID 91274
Smiles CC3=C(SC=C3)/C(C2=C(C)C=CS2)=C\CCN1C[C@H](C(O)=O)CCC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Tiagabine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 20.6 50
DMSO 41.2 100

Preparing Stock Solutions for Tiagabine hydrochloride

The following data is based on the product molecular weight 412.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.43 mL 12.14 mL 24.27 mL
5 mM 0.49 mL 2.43 mL 4.85 mL
10 mM 0.24 mL 1.21 mL 2.43 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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Product Datasheets for Tiagabine hydrochloride

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Keywords: Tiagabine hydrochloride, Tiagabine hydrochloride supplier, antiepileptic, anticonvulsants, gaba, transporters, uptake, inhibitors, inhibits, gat-1, selective, antinociception, antinociceptive, GABA, Transporters, 4256, Tocris Bioscience

2 Citations for Tiagabine hydrochloride

Citations are publications that use Tocris products. Selected citations for Tiagabine hydrochloride include:

María Victoria et al (2017) GAT-1 mediated GABA uptake in rat oligodendrocytes. Glia 65 514-522 PMID: 28071826

Sathyanesan (2018) Neonatal brain injury causes cerebellar learning deficits and Purkinje cell dysfunction. Nature Communications 9 3235 PMID: 30104642

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.