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Submit ReviewTHPN
Discontinued Product
6017 has been discontinued.
View all Nerve Growth Factor IB-like Receptors products.
Description: Nur77 agonist; induces autophagy in melanoma cell lines
Chemical Name: 1-(3,4,5-Trihydroxyphenyl)-1-nonanone
Purity: ≥98% (HPLC)
Biological Activity for THPN
THPN is a Nur77 agonist. Binds Nur77 and promotes translocation of the receptor to the mitochondria resulting in autophagy in melanoma cell lines.
Technical Data for THPN
| M. Wt | 266.33 |
| Formula | C15H22O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 100079-26-3 |
| PubChem ID | 3063200 |
| InChI Key | NVFRHTFJDGAFQS-UHFFFAOYSA-N |
| Smiles | CCCCCCCCC(C1=CC(O)=C(C(O)=C1)O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for THPN
References for THPN
References are publications that support the biological activity of the product.
Wang et al (2014) Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat.Chem.Biol. 10 133 PMID: 24316735
Li et al (2015) Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nat.Chem.Biol. 11 339 PMID: 25822914
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Keywords: THPN, THPN supplier, Nur77, agonist, agonism, binds, TR3, NGFIB, autophagy, GFRP1, Nerve, Growth, Factor, IB-like, Receptors, 6017, Tocris Bioscience
Citations for THPN
Citations are publications that use Tocris products.
Currently there are no citations for THPN.
Reviews for THPN
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for THPN
MAPK Signaling Pathway
The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.