THPN
Biological Activity
Nur77 agonist. Binds Nur77 and promotes translocation of the receptor to the mitochondria resulting in autophagy in melanoma cell lines.
Technical Data
| M. Wt | 266.33 |
| Formula | C15H22O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 100079-26-3 |
| PubChem ID | 3063200 |
| InChI Key | NVFRHTFJDGAFQS-UHFFFAOYSA-N |
| Smiles | CCCCCCCCC(C1=CC(O)=C(C(O)=C1)O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.63 | 100 | |
| ethanol | 26.63 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 266.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.75 mL | 18.77 mL | 37.55 mL |
| 5 mM | 0.75 mL | 3.75 mL | 7.51 mL |
| 10 mM | 0.38 mL | 1.88 mL | 3.75 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.75 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Wang et al (2014) Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat.Chem.Biol. 10 133 PMID: 24316735
Li et al (2015) Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nat.Chem.Biol. 11 339 PMID: 25822914
If you know of a relevant reference for THPN, please let us know.
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Keywords: THPN, THPN supplier, Nur77, agonist, agonism, binds, TR3, NGFIB, autophagy, GFRP1, Nerve, Growth, Factor, IB-like, Receptors, 6017, Tocris Bioscience
Citations for THPN
Citations are publications that use Tocris products.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
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- Cancer Metabolism
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- Hypertension
- Thrombosis and Hemostasis
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- Heart Failure
Immunology Product Listing
A collection of over 190 products for immunology research, the guide includes research tools for the study of:
- Chemokine and Cytokine Signaling
- Chemotaxis
- Complement System
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A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:
- Androgen Receptors
- Estrogen Receptors
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- Retinoid X Receptors
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MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Foundations of Immuno-oncology eBook
In this eBook, we examine the complexity of the tumor microenvironment, explore technologies that are innovating basic and translational research, and strategies that are advancing immunotherapy into the clinic.
Topics covered:
- Tumor Microenvironment
- Immune Checkpoints
- Therapeutic Monoclonal Antibodies
- Small Molecules & Immuno-Oncology
- Cell-based Therapeutics
- Cytokines and Immunotherapy
- Tools to Advance Your Immuno-Oncology Research
Pathways for THPN
MAPK Signaling Pathway
The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.
