Pricing Availability   Qty
Description: Nur77 agonist; induces autophagy in melanoma cell lines
Chemical Name: 1-(3,4,5-Trihydroxyphenyl)-1-nonanone
Purity: ≥98% (HPLC)
Literature (5)
Pathways (1)

Biological Activity for THPN

THPN is a Nur77 agonist. Binds Nur77 and promotes translocation of the receptor to the mitochondria resulting in autophagy in melanoma cell lines.

Technical Data for THPN

M. Wt 266.33
Formula C15H22O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 100079-26-3
PubChem ID 3063200
Smiles CCCCCCCCC(C1=CC(O)=C(C(O)=C1)O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for THPN

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 26.63 100
ethanol 26.63 100

Preparing Stock Solutions for THPN

The following data is based on the product molecular weight 266.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.75 mL 18.77 mL 37.55 mL
5 mM 0.75 mL 3.75 mL 7.51 mL
10 mM 0.38 mL 1.88 mL 3.75 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

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References for THPN

References are publications that support the biological activity of the product.

Wang et al (2014) Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat.Chem.Biol. 10 133 PMID: 24316735

Li et al (2015) Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nat.Chem.Biol. 11 339 PMID: 25822914

If you know of a relevant reference for THPN, please let us know.

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Keywords: THPN, THPN supplier, Nur77, agonist, agonism, binds, TR3, NGFIB, autophagy, GFRP1, Nerve, Growth, Factor, IB-like, Receptors, 6017, Tocris Bioscience

Citations for THPN

Citations are publications that use Tocris products.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Pathways for THPN

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