Discontinued Product

THPN (Cat. No. 6017) has been withdrawn from sale for commercial reasons.
Description: Nur77 agonist; induces autophagy in melanoma cell lines
Chemical Name: 1-(3,4,5-Trihydroxyphenyl)-1-nonanone
Purity: ≥98% (HPLC)
Literature (1)
Pathways (1)

Biological Activity for THPN

THPN is a Nur77 agonist. Binds Nur77 and promotes translocation of the receptor to the mitochondria resulting in autophagy in melanoma cell lines.

Technical Data for THPN

M. Wt 266.33
Formula C15H22O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 100079-26-3
PubChem ID 3063200
Smiles CCCCCCCCC(C1=CC(O)=C(C(O)=C1)O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for THPN

References are publications that support the biological activity of the product.

Wang et al (2014) Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat.Chem.Biol. 10 133 PMID: 24316735

Li et al (2015) Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nat.Chem.Biol. 11 339 PMID: 25822914

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Keywords: THPN, THPN supplier, Nur77, agonist, agonism, binds, TR3, NGFIB, autophagy, GFRP1, Nerve, Growth, Factor, IB-like, Receptors, 6017, Tocris Bioscience

Citations for THPN

Citations are publications that use Tocris products.

Currently there are no citations for THPN.

Reviews for THPN

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for THPN

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.
NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.