THPN

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Cat.No. 6017 - THPN | C15H22O4 | CAS No. 100079-26-3
Description: Nur77 agonist; induces autophagy in melanoma cell lines
Chemical Name: 1-(3,4,5-Trihydroxyphenyl)-1-nonanone
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Nur77 agonist. Binds Nur77 and promotes translocation of the receptor to the mitochondria resulting in autophagy in melanoma cell lines.

Technical Data

M. Wt 266.33
Formula C15H22O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 100079-26-3
PubChem ID 3063200
InChI Key NVFRHTFJDGAFQS-UHFFFAOYSA-N
Smiles CCCCCCCCC(C1=CC(O)=C(C(O)=C1)O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.63 100
ethanol 26.63 100

Preparing Stock Solutions

The following data is based on the product molecular weight 266.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.75 mL 18.77 mL 37.55 mL
5 mM 0.75 mL 3.75 mL 7.51 mL
10 mM 0.38 mL 1.88 mL 3.75 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Wang et al (2014) Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat.Chem.Biol. 10 133 PMID: 24316735

Li et al (2015) Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nat.Chem.Biol. 11 339 PMID: 25822914


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Keywords: THPN, THPN supplier, Nur77, agonist, agonism, binds, TR3, NGFIB, autophagy, Other, Nuclear, Receptors, 6017, Tocris Bioscience

Citations for THPN

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