THPN

Cat. No. 6017 Submit a Review Datasheet / COA / SDS

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Cat.No. 6017 - THPN | C15H22O4 | CAS No. 100079-26-3

Description: Nur77 agonist; induces autophagy in melanoma cell lines

Chemical Name: 1-(3,4,5-Trihydroxyphenyl)-1-nonanone

Purity: ≥98% (HPLC)

Datasheet

Citations

Reviews

Literature (5)

Pathways (1)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for THPN

THPN is a Nur77 agonist. Binds Nur77 and promotes translocation of the receptor to the mitochondria resulting in autophagy in melanoma cell lines.

Technical Data for THPN

M. Wt	266.33
Formula	C₁₅H₂₂O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	100079-26-3
PubChem ID	3063200
InChI Key	NVFRHTFJDGAFQS-UHFFFAOYSA-N
Smiles	CCCCCCCCC(C1=CC(O)=C(C(O)=C1)O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for THPN

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	26.63	100
	ethanol	26.63	100

Preparing Stock Solutions for THPN

The following data is based on the product molecular weight 266.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.75 mL	18.77 mL	37.55 mL
5 mM	0.75 mL	3.75 mL	7.51 mL
10 mM	0.38 mL	1.88 mL	3.75 mL
50 mM	0.08 mL	0.38 mL	0.75 mL

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Product Datasheets for THPN

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for THPN

References are publications that support the biological activity of the product.

Wang et al (2014) Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat.Chem.Biol. 10 133 PMID: 24316735

Li et al (2015) Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nat.Chem.Biol. 11 339 PMID: 25822914

If you know of a relevant reference for THPN, please let us know.

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Keywords: THPN, THPN supplier, Nur77, agonist, agonism, binds, TR3, NGFIB, autophagy, GFRP1, Nerve, Growth, Factor, IB-like, Receptors, 6017, Tocris Bioscience

Citations for THPN

Citations are publications that use Tocris products.

Currently there are no citations for THPN. Do you know of a great paper that uses THPN from Tocris? Please let us know.

Reviews for THPN

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for THPN

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.