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Submit ReviewTHPN is a Nur77 agonist. Binds Nur77 and promotes translocation of the receptor to the mitochondria resulting in autophagy in melanoma cell lines.
M. Wt | 266.33 |
Formula | C15H22O4 |
Storage | Store at +4°C |
Purity | ≥98% (HPLC) |
CAS Number | 100079-26-3 |
PubChem ID | 3063200 |
InChI Key | NVFRHTFJDGAFQS-UHFFFAOYSA-N |
Smiles | CCCCCCCCC(C1=CC(O)=C(C(O)=C1)O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Wang et al (2014) Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat.Chem.Biol. 10 133 PMID: 24316735
Li et al (2015) Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nat.Chem.Biol. 11 339 PMID: 25822914
Keywords: THPN, THPN supplier, Nur77, agonist, agonism, binds, TR3, NGFIB, autophagy, GFRP1, Nerve, Growth, Factor, IB-like, Receptors, 6017, Tocris Bioscience
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MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.