THIP hydrochloride

Pricing Availability   Qty
Description: GABAA agonist
Alternative Names: Gaboxadol
Chemical Name: 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride
Purity: ≥98% (HPLC)
Citations (13)
Reviews (1)
Literature (2)

Biological Activity for THIP hydrochloride

THIP hydrochloride is a systemically active GABAA receptor agonist and GABAA-ρ receptor antagonist. Displays antinociceptive, anticonvulsant and sedative effects. Hypnotic agent that enhances delta activity within non-REM sleep in rats.

Compound Libraries for THIP hydrochloride

THIP hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for THIP hydrochloride

M. Wt 176.6
Formula C6H8N2O2.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 85118-33-8
PubChem ID 5702253
Smiles Cl.OC1=NOC2=C1CCNC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for THIP hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 17.66 100
DMSO 17.66 100

Preparing Stock Solutions for THIP hydrochloride

The following data is based on the product molecular weight 176.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.66 mL 28.31 mL 56.63 mL
5 mM 1.13 mL 5.66 mL 11.33 mL
10 mM 0.57 mL 2.83 mL 5.66 mL
50 mM 0.11 mL 0.57 mL 1.13 mL

Molarity Calculator

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Product Datasheets for THIP hydrochloride

Certificate of Analysis / Product Datasheet
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References for THIP hydrochloride

References are publications that support the biological activity of the product.

Huckle (2004) Gaboxadol. Lundbeck/Merck Curr.Opin.Investig.Drugs 5 766 PMID: 15298075

Johnston (1996) GABAC receptors: relatively simple transmitter-gated ion channels? TiPS 17 319 PMID: 8885697

Krogsgaard-Larson (1983) 4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity. J.Med.Chem. 26 895 PMID: 6304315

Krogsgaard-Larson (1984) Chemistry and pharmacology of the GABA antagonists THIP (Gaboxadol) and isoguvacine. Drugs Future. 9 597

If you know of a relevant reference for THIP hydrochloride, please let us know.

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Keywords: THIP hydrochloride, THIP hydrochloride supplier, GABAC, antagonists, GABAA, agonists, Receptors, Gaboxadol, GABAA-rho, 0807, Tocris Bioscience

13 Citations for THIP hydrochloride

Citations are publications that use Tocris products. Selected citations for THIP hydrochloride include:

Krook-Magnuson et al (2008) Tonically active inhibition selectively controls feedforward circuits in mouse barrel cortex. J Neurosci 100 932 PMID: 18509076

Patel et al (2016) Context-Dependent Modulation of GABAAR-Mediated Tonic Currents. J Neurophysiol 36 607 PMID: 26758848

Asiedu et al (2012) Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice. J Pain 13 546 PMID: 22537560

Ramaker et al (2012) Effect of ganaxolone and THIP on operant and limited-access ethanol self-administration. Neuropharmacology 63 555 PMID: 22613838

Do you know of a great paper that uses THIP hydrochloride from Tocris? Please let us know.

Reviews for THIP hydrochloride

Average Rating: 5 (Based on 1 Review.)

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THIP and in vivo chloride signals.
By Anonymous on 05/23/2019
Assay Type: In Vivo
Species: Mouse
Cell Line/Tissue: c57Bl6J

used with fiber photometry to validate chloride sensor in vivo. response to footshock was measured at baseline and at 20 min intervals post-injection

injected 8mg/kg I.p. at 1mg/ml in saline

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

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Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.