THIP hydrochloride

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Cat.No. 0807 - THIP hydrochloride | C6H8N2O2.HCl | CAS No. 85118-33-8
Description: GABAA agonist
Alternative Names: Gaboxadol
Chemical Name: 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (13)
Reviews (1)
Literature (7)

Biological Activity

Systemically active GABAA receptor agonist and GABAA-ρ receptor antagonist. Displays antinociceptive, anticonvulsant and sedative effects. Hypnotic agent that enhances delta activity within non-REM sleep in rats.

Compound Libraries

THIP hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 176.6
Formula C6H8N2O2.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 85118-33-8
PubChem ID 5702253
InChI Key ZDZDSZQYRBZPNN-UHFFFAOYSA-N
Smiles Cl.OC1=NOC2=C1CCNC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 17.66 100
DMSO 17.66 100

Preparing Stock Solutions

The following data is based on the product molecular weight 176.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.66 mL 28.31 mL 56.63 mL
5 mM 1.13 mL 5.66 mL 11.33 mL
10 mM 0.57 mL 2.83 mL 5.66 mL
50 mM 0.11 mL 0.57 mL 1.13 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Huckle (2004) Gaboxadol. Lundbeck/Merck Curr.Opin.Investig.Drugs 5 766 PMID: 15298075

Johnston (1996) GABAC receptors: relatively simple transmitter-gated ion channels? TiPS 17 319 PMID: 8885697

Krogsgaard-Larson (1983) 4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity. J.Med.Chem. 26 895 PMID: 6304315

Krogsgaard-Larson (1984) Chemistry and pharmacology of the GABA antagonists THIP (Gaboxadol) and isoguvacine. Drugs Future. 9 597


If you know of a relevant reference for THIP hydrochloride, please let us know.

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Keywords: THIP hydrochloride, THIP hydrochloride supplier, GABAC, antagonists, GABAA, agonists, Receptors, Gaboxadol, GABAA-rho, 0807, Tocris Bioscience

13 Citations for THIP hydrochloride

Citations are publications that use Tocris products. Selected citations for THIP hydrochloride include:

Schmid et al (2010) Blindsight depends on the lateral geniculate nucleus. PLoS One 466 373 PMID: 20574422

Ki and Lim (2019) Sleep-promoting effects of threonine link amino acid metabolism in Drosophila neuron to GABAergic control of sleep drive. Elife 8 PMID: 31313987

Montandon (2017) δ-subunit containing GABAA receptors modulate respiratory networks. Sci Rep 7 18105 PMID: 29273726

Tong et al (2015) Ectopic Expression of α6 and δ GABAA Receptor Subunits in Hilar Somatostatin Neurons Increases Tonic Inhibition and Alters Network Activity in the Dentate Gyrus. J Neurosci 35 16142 PMID: 26658866


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Reviews for THIP hydrochloride

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THIP and in vivo chloride signals.
By Anonymous on 05/23/2019
Assay Type: In Vivo
Species: Mouse
Cell Line/Tissue: c57Bl6J

used with fiber photometry to validate chloride sensor in vivo. response to footshock was measured at baseline and at 20 min intervals post-injection

injected 8mg/kg I.p. at 1mg/ml in saline

review image

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