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Biological Activity for Thiostrepton
Thiostrepton is an antibiotic that inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2). Antitumor agent; induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression.
Technical Data for Thiostrepton
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Thiostrepton
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Thiostrepton
The following data is based on the product molecular weight 1664.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||6.01 mL||30.03 mL||60.06 mL|
|0.5 mM||1.2 mL||6.01 mL||12.01 mL|
|1 mM||0.6 mL||3 mL||6.01 mL|
|5 mM||0.12 mL||0.6 mL||1.2 mL|
References for Thiostrepton
References are publications that support the biological activity of the product.
Ruben et al (2007) Thiostrepton inhibition of tRNA delivery to the ribosome. RNA 13 2091 PMID: 17951333
Kwok et al (2008) Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression. Mol.Cancer Ther. 7 2022 PMID: 18645012
Rodnina et al (1999) Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome. Proc.Natl.Acad.Sci.USA 96 9586
If you know of a relevant reference for Thiostrepton, please let us know.
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Keywords: Thiostrepton, Thiostrepton supplier, Downregulates, FOXM1, Antibiotics, inhibits, inhibitors, Hh, Signaling, Signalling, Hedgehog, Transcription, Factors, protein, synthesis, DNA,, RNA, and, Protein, Synthesis, Other, 3267, Tocris Bioscience
3 Citations for Thiostrepton
Citations are publications that use Tocris products. Selected citations for Thiostrepton include:
Huang et al (2019) FoxM1 Induced PTX Resistance via Activation of the FoxM1/PHB1/RAF-MEK-ERK Pathway and Enhancement of the ABCA2 Transporter. Mol Ther Oncolytics 14 196 PMID: 31334335
Lin et al (2013) Inhibition of FOXM1 by thiostrepton sensitizes medulloblastoma to the effects of chemotherapy. Oncol Rep 30 1739 PMID: 23912794
Uddin et al (2011) Genome-wide expression analysis of Middle Eastern colorectal cancer reveals FOXM1 as a novel target for cancer therapy. Am J Pathol 178 537 PMID: 21281787
Do you know of a great paper that uses Thiostrepton from Tocris? Please let us know.
Reviews for Thiostrepton
Average Rating: 5 (Based on 1 Review.)
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Thiostrepton was used to treat acquired cisplatin resistance in breast cancer cells under in in vitro conditions.
Insoluble in the lower alcohols, nonpolar organic solvents, diluted aqueous acids or bases
Literature in this Area
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