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Cat.No. 3267 - Thiostrepton | C72H85N19O18S5 | CAS No. 1393-48-2
Description: Antibiotic, inhibits protein synthesis
Purity: ≥90% (HPLC)
Citations (3)
Reviews (1)
Literature (2)

Biological Activity for Thiostrepton

Thiostrepton is an antibiotic that inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2). Antitumor agent; induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression.

Technical Data for Thiostrepton

M. Wt 1664.89
Formula C72H85N19O18S5
Storage Store at -20°C
Purity ≥90% (HPLC)
CAS Number 1393-48-2
PubChem ID 16129666
Smiles C=C(C(NC(C(N)=O)=C)=O)NC(C1=CSC(C2=NC(C3=CSC(C(C(C)OC(C4=CC(C(C)O)=C(C=CC(NC(C(NC(C)C(NC(C(NC(C)C5=O)=O)=C)=O)=O)C(C)CC)C6O)C6=N4)=O)N7)=N3)C(CC2)(N5)C8=NC(C(NC(C(N/C(C9=NC(C(NC(C(O)(C)C(C)O)C%10=NC(C7=O)=CS%10)=O)CS9)=C/C)=O)C(O)C)=O)=CS8)=N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Thiostrepton

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 16.65 10

Preparing Stock Solutions for Thiostrepton

The following data is based on the product molecular weight 1664.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 6.01 mL 30.03 mL 60.06 mL
0.5 mM 1.2 mL 6.01 mL 12.01 mL
1 mM 0.6 mL 3 mL 6.01 mL
5 mM 0.12 mL 0.6 mL 1.2 mL

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Product Datasheets for Thiostrepton

Certificate of Analysis / Product Datasheet
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References for Thiostrepton

References are publications that support the biological activity of the product.

Ruben et al (2007) Thiostrepton inhibition of tRNA delivery to the ribosome. RNA 13 2091 PMID: 17951333

Kwok et al (2008) Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression. Mol.Cancer Ther. 7 2022 PMID: 18645012

Rodnina et al (1999) Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome. Proc.Natl.Acad.Sci.USA 96 9586

If you know of a relevant reference for Thiostrepton, please let us know.

View Related Products by Product Action

View all DNA, RNA and Protein Synthesis Inhibitors

Keywords: Thiostrepton, Thiostrepton supplier, Downregulates, FOXM1, Antibiotics, inhibits, inhibitors, Hh, Signaling, Signalling, Hedgehog, Transcription, Factors, protein, synthesis, DNA,, RNA, and, Protein, Synthesis, Other, 3267, Tocris Bioscience

3 Citations for Thiostrepton

Citations are publications that use Tocris products. Selected citations for Thiostrepton include:

Huang et al (2019) FoxM1 Induced PTX Resistance via Activation of the FoxM1/PHB1/RAF-MEK-ERK Pathway and Enhancement of the ABCA2 Transporter. Mol Ther Oncolytics 14 196 PMID: 31334335

Lin et al (2013) Inhibition of FOXM1 by thiostrepton sensitizes medulloblastoma to the effects of chemotherapy. Oncol Rep 30 1739 PMID: 23912794

Uddin et al (2011) Genome-wide expression analysis of Middle Eastern colorectal cancer reveals FOXM1 as a novel target for cancer therapy. Am J Pathol 178 537 PMID: 21281787

Do you know of a great paper that uses Thiostrepton from Tocris? Please let us know.

Reviews for Thiostrepton

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Thiostrepton was used to treat acquired cisplatin resistance.
By Anonymous on 02/27/2019
Assay Type: In Vitro
Species: Human

Thiostrepton was used to treat acquired cisplatin resistance in breast cancer cells under in in vitro conditions.

Insoluble in the lower alcohols, nonpolar organic solvents, diluted aqueous acids or bases

review image

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