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THDOC is a positive modulator of GABAA receptors. Potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro. Endogenous neurosteroid.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 334.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.99 mL||14.95 mL||29.9 mL|
|5 mM||0.6 mL||2.99 mL||5.98 mL|
|10 mM||0.3 mL||1.49 mL||2.99 mL|
|50 mM||0.06 mL||0.3 mL||0.6 mL|
References are publications that support the biological activity of the product.
Villumsen et al (2015) Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes. BMC.Neurosci. 16 PMID: 25887256
Adams et al (2015) Modulation of neurosteroid potentiation by protein kinases at synaptic- and extrasynaptic-type GABAA receptors. Neuropharmacology. 88 63 PMID: 25278033
If you know of a relevant reference for THDOC, please let us know.
Keywords: THDOC, THDOC supplier, GABAA, receptor, modulators, modulates, positive, neurosteroid, endogenous, Receptors, 6334, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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