Pricing Availability   Qty
Description: Positive modulator of GABAA receptors; endogenous neurosteroid
Chemical Name: (3α,5α)-3,21-Dihydroxypregnan-20-one
Purity: ≥95% (HPLC)
Literature (2)

Biological Activity for THDOC

THDOC is a positive modulator of GABAA receptors. Potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro. Endogenous neurosteroid.

Technical Data for THDOC

M. Wt 334.49
Formula C21H34O3
Storage Store at RT
Purity ≥95% (HPLC)
CAS Number 567-02-2
PubChem ID 91475
Smiles [H][C@@]12CC[C@@H]([C@]1(CC[C@]3([C@]2(CC[C@]4(C[C@@H](CC[C@]34C)O)[H])[H])[H])C)C(CO)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for THDOC

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.45 100
ethanol 33.45 100

Preparing Stock Solutions for THDOC

The following data is based on the product molecular weight 334.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.99 mL 14.95 mL 29.9 mL
5 mM 0.6 mL 2.99 mL 5.98 mL
10 mM 0.3 mL 1.49 mL 2.99 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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References for THDOC

References are publications that support the biological activity of the product.

Villumsen et al (2015) Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes. BMC.Neurosci. 16 PMID: 25887256

Adams et al (2015) Modulation of neurosteroid potentiation by protein kinases at synaptic- and extrasynaptic-type GABAA receptors. Neuropharmacology. 88 63 PMID: 25278033

If you know of a relevant reference for THDOC, please let us know.

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Keywords: THDOC, THDOC supplier, GABAA, receptor, modulators, modulates, positive, neurosteroid, endogenous, Receptors, 6334, Tocris Bioscience

Citations for THDOC

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.