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Hepatitis C virus (HCV) protease NS3/4A inhibitor. Orally bioavailable. Inhibits HCV RNA replication in vitro (IC50 = 0.35 μM). Also used in Stabilizable Polypeptide Linkages (StaPLs) chemogenetic platform, for pharmacological regulation of protein expression/function. StaPL sequences can be engineered into target proteins rendering them functional only in the presence of Telaprevir.
Plasmid vectors for the transfection of cells with StaPLs are available from Addgene.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 679.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.47 mL||7.35 mL||14.71 mL|
|5 mM||0.29 mL||1.47 mL||2.94 mL|
|10 mM||0.15 mL||0.74 mL||1.47 mL|
|50 mM||0.03 mL||0.15 mL||0.29 mL|
References are publications that support the biological activity of the product.
Jacobs et al (2018) StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins. Nat.Methods 15 523 PMID: 29967496
If you know of a relevant reference for Telaprevir, please let us know.
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Keywords: Telaprevir, Telaprevir supplier, hepatitis, C, virus, HCV, NS3, NS4A, protease, inhibitors, inhibits, orally, bioavailable, StaPLs, stabilizable, polypeptide, linkages, Other, Proteases, Hepatitis, Viruses, 6658, Tocris Bioscience
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