Pricing Availability   Qty
Description: Hepatitis C virus (HCV) protease NS3/4A inhibitor
Alternative Names: VX-950, LY-570310
Chemical Name: (1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1S)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide
Purity: ≥98% (HPLC)

Biological Activity for Telaprevir

Telaprevir is a hepatitis C virus (HCV) protease NS3/4A inhibitor. Orally bioavailable. Inhibits HCV RNA replication in vitro (IC50 = 0.35 μM). Also used in Stabilizable Polypeptide Linkages (StaPLs) chemogenetic platform, for pharmacological regulation of protein expression/function. StaPL sequences can be engineered into target proteins rendering them functional only in the presence of Telaprevir.

Plasmid vectors for the transfection of cells with StaPLs are available from Addgene.

Technical Data for Telaprevir

M. Wt 679.85
Formula C36H53N7O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 402957-28-2
PubChem ID 3010818
Smiles [H][C@@]12CCC[C@@]1([C@@H](C(N[C@H](C(C(NC3CC3)=O)=O)CCC)=O)N(C([C@H](C(C)(C)C)NC([C@H](C4CCCCC4)NC(C5=NC=CN=C5)=O)=O)=O)C2)[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Telaprevir

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 67.98 100

Preparing Stock Solutions for Telaprevir

The following data is based on the product molecular weight 679.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.47 mL 7.35 mL 14.71 mL
5 mM 0.29 mL 1.47 mL 2.94 mL
10 mM 0.15 mL 0.74 mL 1.47 mL
50 mM 0.03 mL 0.15 mL 0.29 mL

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References for Telaprevir

References are publications that support the biological activity of the product.

Jacobs et al (2018) StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins. Nat.Methods 15 523 PMID: 29967496

If you know of a relevant reference for Telaprevir, please let us know.

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Keywords: Telaprevir, Telaprevir supplier, hepatitis, C, virus, HCV, NS3, NS4A, protease, inhibitors, inhibits, orally, bioavailable, StaPLs, stabilizable, polypeptide, linkages, VX-950, LY-570310, Other, Proteases, Hepatitis, Viruses, 6658, Tocris Bioscience

Citations for Telaprevir

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Currently there are no citations for Telaprevir. Do you know of a great paper that uses Telaprevir from Tocris? Please let us know.

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