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Discontinued ProductTelaprevir (Cat. No. 6658) has been withdrawn from sale for commercial reasons.
Biological Activity for Telaprevir
Telaprevir is a hepatitis C virus (HCV) protease NS3/4A inhibitor. Orally bioavailable. Inhibits HCV RNA replication in vitro (IC50 = 0.35 μM). Also used in Stabilizable Polypeptide Linkages (StaPLs) chemogenetic platform, for pharmacological regulation of protein expression/function. StaPL sequences can be engineered into target proteins rendering them functional only in the presence of Telaprevir.
Plasmid vectors for the transfection of cells with StaPLs are available from Addgene.
Technical Data for Telaprevir
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for Telaprevir
References are publications that support the biological activity of the product.
Jacobs et al (2018) StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins. Nat.Methods 15 523 PMID: 29967496
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Citations for Telaprevir
Citations are publications that use Tocris products.
Currently there are no citations for Telaprevir.
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