TCS 183

Pricing Availability Delivery Time Qty
Cat.No. 2236 - TCS 183 | Met-Ser-Gly-Arg-Pro-Arg-Thr-Thr-Ser-Phe-Ala-Glu-Ser-NH2
Description: Fragment 1-13 of GSK-3β sequence
Datasheet
Citations (1)
Reviews (1)
Literature

Biological Activity

Fragment 1-13 of human and mouse GSK-3β sequence. Potentially useful as a competitive inhibitor of GSK-3β (Ser9) phosphorylation.

Control Peptide also available.

Technical Data

M. Wt 1425.58
Formula C58H96N20O20S
Sequence MSGRPRTTSFAES

(Modifications: Ser-13 = C-terminal amide)

Storage Desiccate at -20°C
PubChem ID 90488752
InChI Key CPHAYBWPVDHKAJ-BOGMMOMNSA-N
Smiles [H]N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1425.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.7 mL 3.51 mL 7.01 mL
5 mM 0.14 mL 0.7 mL 1.4 mL
10 mM 0.07 mL 0.35 mL 0.7 mL
50 mM 0.01 mL 0.07 mL 0.14 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Peineau et al (2007) GSK3β mediates a novel interaction between LTP and LTD in the hippocampus. Neuron 53 703 PMID: 17329210


If you know of a relevant reference for TCS 183, please let us know.

Keywords: TCS 183, supplier, Fragment, 1-13, GSK-3β, GSK-3beta, sequence, Glycogen, Synthase, Kinases, 3, Carbohydrate, Metabolism, TCS183, Glycogen, Synthase, Kinase, 3, Glycogen, Synthase, Kinase, Glycogen, Synthase, Kinase, 3, Tocris Bioscience

1 Citation for TCS 183

Citations are publications that use Tocris products. Selected citations for TCS 183 include:

Peineau et al (2007) LTP inhibits LTD in the hippocampus via regulation of GSK3beta. Neuron 53 703 PMID: 17329210


Do you know of a great paper that uses TCS 183 from Tocris? If so please let us know.

Reviews for TCS 183

Average Rating: 5 (Based on 1 Review)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used TCS 183?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Filter by:


TCS-183 efficiently blocks Wnt/ beta-catenin pathway in vivo
By Jessica Vargas on 01/06/2018
Assay Type: In Vivo
Species: Mouse
Cell Line/Tissue: Brain

TCS-183, a competitive inhibitor of the inactivating GSK-3 beta phosphorylation, was used to block the activation of Wnt/ beta-catenin pathway in vivo. 300 micro-Molar of TCS-183 was diluted in sterile artificial cerebrospinal fluid and 0.01% DMSO. Chronic intracerebral delivery of the product was achieved via an osmotic mini-pump implanted on C57BL/6 mice.

PMID: 24501359
review image

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Alzheimer's

Alzheimer's Poster

Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.

Schizophrenia

Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.