TCS 183

Pricing Availability Delivery Time Qty
Cat.No. 2236 - TCS 183 | Met-Ser-Gly-Arg-Pro-Arg-Thr-Thr-Ser-Phe-Ala-Glu-Ser-NH2
Description: Fragment 1-13 of GSK-3β sequence
Datasheet
Citations (1)
Literature

Biological Activity

Fragment 1-13 of human and mouse GSK-3β sequence. Potentially useful as a competitive inhibitor of GSK-3β (Ser9) phosphorylation. Control peptide TCS 184 available (Cat. No. 2320).

Technical Data

M. Wt 1425.58
Formula C58H96N20O20S
Sequence MSGRPRTTSFAES

(Modifications: Ser-13 = C-terminal amide)

Storage Desiccate at -20°C
PubChem ID 90488752
InChI Key CPHAYBWPVDHKAJ-BOGMMOMNSA-N
Smiles [H]N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1425.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.7 mL 3.51 mL 7.01 mL
5 mM 0.14 mL 0.7 mL 1.4 mL
10 mM 0.07 mL 0.35 mL 0.7 mL
50 mM 0.01 mL 0.07 mL 0.14 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Peineau et al (2007) GSK3β mediates a novel interaction between LTP and LTD in the hippocampus. Neuron 53 703 PMID: 17329210


If you know of a relevant reference for TCS 183, please let us know.

Keywords: TCS 183, supplier, Fragment, 1-13, GSK-3β, GSK-3beta, sequence, Glycogen, Synthase, Kinases, 3, Carbohydrate, Metabolism, TCS183, Glycogen, Synthase, Kinase, 3, Tocris Bioscience

1 Citation for TCS 183

Citations are publications that use Tocris products. Selected citations for TCS 183 include:

Peineau et al (2007) LTP inhibits LTD in the hippocampus via regulation of GSK3beta. Neuron 53 703 PMID: 17329210


Do you know of a great paper that uses TCS 183 from Tocris? If so please let us know.

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Reviews

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Pathways for TCS 183

Protocols

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