TCS 1105

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Cat.No. 3942 - TCS 1105 | C17H13FN2O2 | CAS No. 185391-33-7
Description: GABAA α2 benzodiazepine receptor agonist
Chemical Name: N-[(-4-Fluorophenyl)methyl]-α-oxo-1H-indole-3-acetamide
Purity: ≥99% (HPLC)

Biological Activity

GABAA benzodiazepine receptor (BZR) ligand. Acts as an agonist at α2 and antagonist at α1 benzodiazepine receptors (Ki values are 118 and 245 nM respectively). Anxiolytic agent lacking sedative activity.

Technical Data

M. Wt 296.3
Formula C17H13FN2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 185391-33-7
PubChem ID 2986030
Smiles O=C(C(NCC3=CC=C(F)C=C3)=O)C2=CNC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 5.93 20
DMSO 29.63 100

Preparing Stock Solutions

The following data is based on the product molecular weight 296.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.37 mL 16.87 mL 33.75 mL
5 mM 0.67 mL 3.37 mL 6.75 mL
10 mM 0.34 mL 1.69 mL 3.37 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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Product Datasheets

Safety Datasheet


References are publications that support the biological activity of the product.

Taliani et al (2009) Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the γ-aminobutyric acid-A (GABAA) α2 benzodiazepine receptor. J.Med.Chem 52 3723 PMID: 19469479

If you know of a relevant reference for TCS 1105, please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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