TCS 1105

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Cat.No. 3942 - TCS 1105 | C17H13FN2O2 | CAS No. 185391-33-7
Description: GABAA α2 benzodiazepine receptor agonist
Chemical Name: N-[(-4-Fluorophenyl)methyl]-α-oxo-1H-indole-3-acetamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

GABAA benzodiazepine receptor (BZR) ligand. Acts as an agonist at α2 and antagonist at α1 benzodiazepine receptors (Ki values are 118 and 245 nM respectively). Anxiolytic agent lacking sedative activity.

Technical Data

M. Wt 296.3
Formula C17H13FN2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 185391-33-7
PubChem ID 2986030
InChI Key VWCCHJFFYCGXFL-UHFFFAOYSA-N
Smiles O=C(C(NCC3=CC=C(F)C=C3)=O)C2=CNC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.63 100
ethanol 5.93 20

Preparing Stock Solutions

The following data is based on the product molecular weight 296.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.37 mL 16.87 mL 33.75 mL
5 mM 0.67 mL 3.37 mL 6.75 mL
10 mM 0.34 mL 1.69 mL 3.37 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Taliani et al (2009) Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the γ-aminobutyric acid-A (GABAA) α2 benzodiazepine receptor. J.Med.Chem 52 3723 PMID: 19469479


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Keywords: TCS1105 alpha2 agonist alpha1 antagonist GABA a1 a2 α2 α1 GABAA benzodiazepine receptor BZR GABAA Receptors

Citations for TCS 1105

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Pathways for TCS 1105

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