TCS 1105

Discontinued Product

TCS 1105 (Cat. No. 3942) has been withdrawn from sale for commercial reasons.
Cat.No. 3942 - TCS 1105 | C17H13FN2O2 | CAS No. 185391-33-7
Description: GABAA α2 benzodiazepine agonist
Chemical Name: N-[(-4-Fluorophenyl)methyl]-α-oxo-1H-indole-3-acetamide
Purity: ≥99% (HPLC)
Literature (7)

Biological Activity for TCS 1105

GABAA benzodiazepine receptor (BZR) ligand. Acts as an agonist at α2 and antagonist at α1 benzodiazepine receptors (Ki values are 118 and 245 nM respectively). Anxiolytic agent lacking sedative activity.

Technical Data for TCS 1105

M. Wt 296.3
Formula C17H13FN2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 185391-33-7
PubChem ID 2986030
Smiles O=C(C(NCC3=CC=C(F)C=C3)=O)C2=CNC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for TCS 1105

References are publications that support the biological activity of the product.

Taliani et al (2009) Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the γ-aminobutyric acid-A (GABAA) α2 benzodiazepine receptor. J.Med.Chem 52 3723 PMID: 19469479

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Citations for TCS 1105

Citations are publications that use Tocris products.

Currently there are no citations for TCS 1105.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

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