Positive allosteric modulator of mGlu4 receptors (EC50 = 1.0 μM for human and rat mGlu4 receptors). Orally available and brain penetrant.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 197.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.07 mL||25.35 mL||50.7 mL|
|5 mM||1.01 mL||5.07 mL||10.14 mL|
|10 mM||0.51 mL||2.53 mL||5.07 mL|
|50 mM||0.1 mL||0.51 mL||1.01 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
East et al (2010) An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction. Bioorg.Med.Chem.Lett. 20 4901 PMID: 20638279
If you know of a relevant reference for TCN 238, please let us know.
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Keywords: TCN238 metabotropic glutamate mglu4 positive allosteric modulators pams Glutamate (Metabotropic) Group III Receptors
1 Citation for TCN 238
Citations are publications that use Tocris products. Selected citations for TCN 238 include:
Pershina and Arkhipov (2016) Subacute activation of mGlu4 receptors causes the feedback inhibition of its gene expression in rat brain. Life Sci. 153 50 PMID: 27055390
Do you know of a great paper that uses TCN 238 from Tocris? If so please let us know.
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