Positive allosteric modulator of mGlu4 receptors (EC50 = 1.0 μM for human and rat mGlu4 receptors). Orally available and brain penetrant.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 197.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.07 mL||25.35 mL||50.7 mL|
|5 mM||1.01 mL||5.07 mL||10.14 mL|
|10 mM||0.51 mL||2.53 mL||5.07 mL|
|50 mM||0.1 mL||0.51 mL||1.01 mL|
References are publications that support the products' biological activity.
East et al (2010) An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction. Bioorg.Med.Chem.Lett. 20 4901 PMID: 20638279
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Keywords: TCN 238, supplier, TCN238, metabotropic, glutamate, mglu4, positive, allosteric, modulators, pams, Glutamate, (Metabotropic), Group, III, Receptors, Glutamate, (Metabotropic), Group, III, Receptors, Tocris Bioscience
1 Citation for TCN 238
Citations are publications that use Tocris products. Selected citations for TCN 238 include:
Pershina and Arkhipov (2016) Subacute activation of mGlu4 receptors causes the feedback inhibition of its gene expression in rat brain. Life Sci. 153 50 PMID: 27055390
Do you know of a great paper that uses TCN 238 from Tocris? If so please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
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