TCN 238

Pricing Availability Delivery Time Qty
Cat.No. 4259 - TCN 238 | C12H11N3 | CAS No. 125404-04-8
Description: Positive allosteric modulator of mGlu4
Chemical Name: (E)-4-(2-Phenylethenyl)-2-pyrimidinamine
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Positive allosteric modulator of mGlu4 receptors (EC50 = 1.0 μM for human and rat mGlu4 receptors). Orally available and brain penetrant.

Compound Libraries

TCN 238 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 197.24
Formula C12H11N3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 125404-04-8
PubChem ID 46911068
InChI Key LNUXNUNUGIHCPA-VOTSOKGWSA-N
Smiles NC1=NC(/C=C/C2=CC=CC=C2)=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.72 100
ethanol 1.97 10

Preparing Stock Solutions

The following data is based on the product molecular weight 197.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.07 mL 25.35 mL 50.7 mL
5 mM 1.01 mL 5.07 mL 10.14 mL
10 mM 0.51 mL 2.53 mL 5.07 mL
50 mM 0.1 mL 0.51 mL 1.01 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

East et al (2010) An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction. Bioorg.Med.Chem.Lett. 20 4901 PMID: 20638279


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Keywords: TCN238 metabotropic glutamate mglu4 positive allosteric modulators pams Glutamate (Metabotropic) Group III Receptors

1 Citation for TCN 238

Citations are publications that use Tocris products. Selected citations for TCN 238 include:

Pershina and Arkhipov (2016) Subacute activation of mGlu4 receptors causes the feedback inhibition of its gene expression in rat brain. Life Sci. 153 50 PMID: 27055390


Do you know of a great paper that uses TCN 238 from Tocris? If so please let us know.

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Pathways for TCN 238

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