TC-N 22A
Biological Activity
Potent and selective mGlu4 receptor positive allosteric modulator (EC50 = 9 nM in human mGlu4-expressing BHK cells). Selective for mGlu4 over mGlu1, mGlu2, mGlu3, mGlu5 and mGlu7 receptors (EC50 values are > 10 μM). Brain penetrant.
Technical Data
| M. Wt | 283.35 |
| Formula | C14H13N5S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1314140-00-5 |
| PubChem ID | 46836562 |
| InChI Key | DBISXWCOHGUFSF-UHFFFAOYSA-N |
| Smiles | C2(SC(NC4=NC=CC=C4)=N3)=C3C1=CNN=C1CCC2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 14.17 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 283.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.53 mL | 17.65 mL | 35.29 mL |
| 5 mM | 0.71 mL | 3.53 mL | 7.06 mL |
| 10 mM | 0.35 mL | 1.76 mL | 3.53 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.71 mL |
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References
References are publications that support the products' biological activity.
Hong et al (2011) Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators. J.Med.Chem. 54 5070 PMID: 21688779
If you know of a relevant reference for TC-N 22A, please let us know.
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Keywords: metabotropics glutamate 4 receptors positive allosteric modulators brain penetrant mglur4 mglu pams TC-N22A Glutamate (Metabotropic) Group III Receptors
Citations for TC-N 22A
Citations are publications that use Tocris products.
Currently there are no citations for TC-N 22A. Do you know of a great paper that uses TC-N 22A from Tocris? If so please let us know.
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