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Description: Potent and selective positive allosteric modulator of mGlu4 receptors
Chemical Name: 4,5,6,8-Tetrahydro-N-2-pyridinylpyrazolo[3',4':6,7]cyclohepta[1,2]thiazol-2-amine
Purity: ≥98% (HPLC)
Biological Activity for TC-N 22A
TC-N 22A is a potent and selective mGlu4 receptor positive allosteric modulator (EC50 = 9 nM in human mGlu4-expressing BHK cells). Selective for mGlu4 over mGlu1, mGlu2, mGlu3, mGlu5 and mGlu7 receptors (EC50 values are > 10 μM). Brain penetrant.
Technical Data for TC-N 22A
| M. Wt | 283.35 |
| Formula | C14H13N5S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1314140-00-5 |
| PubChem ID | 46836562 |
| InChI Key | DBISXWCOHGUFSF-UHFFFAOYSA-N |
| Smiles | C2(SC(NC4=NC=CC=C4)=N3)=C3C1=CNN=C1CCC2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for TC-N 22A
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 14.17 | 50 |
Preparing Stock Solutions for TC-N 22A
The following data is based on the product molecular weight 283.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 7.06 mL | 35.29 mL | 70.58 mL |
| 2.5 mM | 1.41 mL | 7.06 mL | 14.12 mL |
| 5 mM | 0.71 mL | 3.53 mL | 7.06 mL |
| 25 mM | 0.14 mL | 0.71 mL | 1.41 mL |
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Product Datasheets for TC-N 22A
References for TC-N 22A
References are publications that support the biological activity of the product.
Hong et al (2011) Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators. J.Med.Chem. 54 5070 PMID: 21688779
If you know of a relevant reference for TC-N 22A, please let us know.
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Keywords: TC-N 22A, TC-N 22A supplier, metabotropics, glutamate, 4, receptors, positive, allosteric, modulators, brain, penetrant, mglur4, mglu, pams, TC-N22A, Glutamate, (Metabotropic), Group, III, Receptors, 4370, Tocris Bioscience
1 Citation for TC-N 22A
Citations are publications that use Tocris products. Selected citations for TC-N 22A include:
Chiu et al (2019) NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content. Cell Rep 28 332 PMID: 31291571
Do you know of a great paper that uses TC-N 22A from Tocris? Please let us know.
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