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Submit ReviewTC-N 22A is a potent and selective mGlu4 receptor positive allosteric modulator (EC50 = 9 nM in human mGlu4-expressing BHK cells). Selective for mGlu4 over mGlu1, mGlu2, mGlu3, mGlu5 and mGlu7 receptors (EC50 values are > 10 μM). Brain penetrant.
M. Wt | 283.35 |
Formula | C14H13N5S |
Storage | Store at +4°C |
Purity | ≥98% (HPLC) |
CAS Number | 1314140-00-5 |
PubChem ID | 46836562 |
InChI Key | DBISXWCOHGUFSF-UHFFFAOYSA-N |
Smiles | C2(SC(NC4=NC=CC=C4)=N3)=C3C1=CNN=C1CCC2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Hong et al (2011) Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators. J.Med.Chem. 54 5070 PMID: 21688779
View all Glutamate (Metabotropic) Group III Receptor Modulators
Keywords: TC-N 22A, TC-N 22A supplier, metabotropics, glutamate, 4, receptors, positive, allosteric, modulators, brain, penetrant, mglur4, mglu, pams, TC-N22A, Glutamate, (Metabotropic), Group, III, Receptors, 4370, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for TC-N 22A include:
Chiu et al (2019) NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content. Cell Rep 28 332 PMID: 31291571
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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