TC-N 22A

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Cat.No. 4370 - TC-N 22A | C14H13N5S | CAS No. 1314140-00-5
Description: Potent and selective positive allosteric modulator of mGlu4 receptors
Chemical Name: 4,5,6,8-Tetrahydro-N-2-pyridinylpyrazolo[3',4':6,7]cyclohepta[1,2]thiazol-2-amine
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (8)

Biological Activity for TC-N 22A

TC-N 22A is a potent and selective mGlu4 receptor positive allosteric modulator (EC50 = 9 nM in human mGlu4-expressing BHK cells). Selective for mGlu4 over mGlu1, mGlu2, mGlu3, mGlu5 and mGlu7 receptors (EC50 values are > 10 μM). Brain penetrant.

Technical Data for TC-N 22A

M. Wt 283.35
Formula C14H13N5S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1314140-00-5
PubChem ID 46836562
InChI Key DBISXWCOHGUFSF-UHFFFAOYSA-N
Smiles C2(SC(NC4=NC=CC=C4)=N3)=C3C1=CNN=C1CCC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC-N 22A

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 14.17 50

Preparing Stock Solutions for TC-N 22A

The following data is based on the product molecular weight 283.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 7.06 mL 35.29 mL 70.58 mL
2.5 mM 1.41 mL 7.06 mL 14.12 mL
5 mM 0.71 mL 3.53 mL 7.06 mL
25 mM 0.14 mL 0.71 mL 1.41 mL

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References for TC-N 22A

References are publications that support the biological activity of the product.

Hong et al (2011) Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators. J.Med.Chem. 54 5070 PMID: 21688779


If you know of a relevant reference for TC-N 22A, please let us know.

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Keywords: TC-N 22A, TC-N 22A supplier, metabotropics, glutamate, 4, receptors, positive, allosteric, modulators, brain, penetrant, mglur4, mglu, pams, TC-N22A, Glutamate, (Metabotropic), Group, III, Receptors, 4370, Tocris Bioscience

1 Citation for TC-N 22A

Citations are publications that use Tocris products. Selected citations for TC-N 22A include:

Chiu et al (2019) NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content. Cell Rep 28 332 PMID: 31291571


Do you know of a great paper that uses TC-N 22A from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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