TC-N 22A

Pricing Availability Delivery Time Qty
Cat.No. 4370 - TC-N 22A | C14H13N5S | CAS No. 1314140-00-5
Description: Potent, selective mGlu4 positive allosteric modulator
Chemical Name: 4,5,6,8-Tetrahydro-N-2-pyridinylpyrazolo[3',4':6,7]cyclohepta[1,2]thiazol-2-amine
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective mGlu4 receptor positive allosteric modulator (EC50 = 9 nM in human mGlu4-expressing BHK cells). Selective for mGlu4 over mGlu1, mGlu2, mGlu3, mGlu5 and mGlu7 receptors (EC50 values are > 10 μM). Brain penetrant.

Technical Data

M. Wt 283.35
Formula C14H13N5S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1314140-00-5
PubChem ID 46836562
InChI Key DBISXWCOHGUFSF-UHFFFAOYSA-N
Smiles C2(SC(NC4=NC=CC=C4)=N3)=C3C1=CNN=C1CCC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 14.17 50

Preparing Stock Solutions

The following data is based on the product molecular weight 283.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.53 mL 17.65 mL 35.29 mL
5 mM 0.71 mL 3.53 mL 7.06 mL
10 mM 0.35 mL 1.76 mL 3.53 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Hong et al (2011) Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators. J.Med.Chem. 54 5070 PMID: 21688779


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Citations for TC-N 22A

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