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Description: Click chemistry auxiliary reagent; stabilizing ligand for copper-catalyzed azide-alkyne cycloaddition reaction
Chemical Name: Tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine
Purity: ≥97% (HPLC)

Biological Activity for TBTA

TBTA is a click chemistry auxiliary reagent. It is a stabilizing ligand for copper-catalyzed azide-alkyne cycloaddition reactions.

Technical Data for TBTA

M. Wt 530.6
Formula C30H30N10
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 510758-28-8
PubChem ID 11203363
Smiles N1(CC2=CC=CC=C2)N=NC(CN(CC3=CN(CC4=CC=CC=C4)N=N3)CC5=CN(CC6=CC=CC=C6)N=N5)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TBTA

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 53.06 100

Preparing Stock Solutions for TBTA

The following data is based on the product molecular weight 530.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.88 mL 9.42 mL 18.85 mL
5 mM 0.38 mL 1.88 mL 3.77 mL
10 mM 0.19 mL 0.94 mL 1.88 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets for TBTA

Certificate of Analysis / Product Datasheet
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References for TBTA

References are publications that support the biological activity of the product.

Pang et al (2022) In situ identification of cellular drug targets in mammalian tissue. Cell 185 1793 PMID: 35483372

Fantoni et al (2021) A hitchhiker's guide to click-chemistry with nucleic acids. Chem.Rev. 121 7122 PMID: 33443411

Kour et al (2021) Stapling proteins in the RELA complex inhibits TNFα-induced nuclear translocation of RELA. RSC Chem.Biol. 3 32 PMID: 35128406

If you know of a relevant reference for TBTA, please let us know.

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Keywords: TBTA, TBTA supplier, Click, Chemistry, azide, alkyne, copper, Cu, catalyzed, stabilizing, ligand, cu, cycloaddition, Biochemicals, and, Molecular, Biology, 7862, Tocris Bioscience

Citations for TBTA

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