Taxol Janelia Fluor® 646

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Description: Red fluorescent taxol derivative; probe for microtubule staining; protocol available
Chemical Name: 2-(3-(Azetidin-1-ium-1-ylidene)-7-(azetidin-1-yl)-5,5-dimethyl-3,5-dihydrodibenzo[b,e]silin-10-yl)-4-(((2S)-1-(((2aR,4S,4aS,6R,9S,11S,12S,12bS)-6,12b-diacetoxy-9-(((2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl)oxy)-12-(benzoyloxy)-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-4-yl)oxy)-1-oxopropan-2-yl)carbamoyl)benzoate
Purity: ≥95% (HPLC)
Citations (1)
Protocols (1)
Literature (1)

Biological Activity for Taxol Janelia Fluor® 646

Taxol Janelia Fluor® 646 is a red fluorescent taxol derivative for direct imaging of the microtubule cytoskeleton. Taxol Janelia Fluor® 646 is fluorogenic: fluoresces only once bound to microtubules, enabling hassle-free no-wash experiments. Excitation maximum = 655 nm; emission maximum = 671 nm.

For more information on how Taxol-Janelia Fluor® 646 may be used, see our protocol.

Scientific Data

Confocal Microscopy COS7 cells dye-labeled with Taxol Janelia Fluor 646 View Larger

Application of Taxol Janelia Fluor® 646, dye on COS7 cells. COS7 cells were labeled with 3 µM Taxol Janelia Fluor® 646 for one hour at 37°C. Images were taken on a Leica TCS SP8 Confocal Laser Scanning Microscope. All images kindly provided by Prof. Christian Soeller, University of Exeter; acquired by Evelina Lucinskaite, Anna Meletiou and Alexander Clowsley.

Licensing Information

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus

Optical Data for Taxol Janelia Fluor® 646

Taxol Janelia Fluor<sup>®</sup> 646 Dye Spectra
Emission Color Red
λabs 655 nm
λem 671 nm
Application Fluorescence Microscopy, Confocal Microscopy

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Technical Data for Taxol Janelia Fluor® 646

M. Wt 1403.62
Formula C79H82N4O18Si
Storage Store at -20°C
Purity ≥95% (HPLC)
Smiles O=C(C)O[C@]12C([C@@]3(C)[C@@H](OC([C@H](C)NC(C4=CC=C(C([O-])=O)C(C5=C(C=C/6)C([Si](C)(C)C7=C5C=CC(N8CCC8)=C7)=CC6=[N+]9CCC\9)=C4)=O)=O)C[C@H]1OC2)[C@H](OC(C%10=CC=CC=C%10)=O)[C@@]%11(O)C(C)(C)C([C@@H](OC(C)=O)C3=O)=C(C)[C@@H](OC([C@H](O)[C@H](C%12=CC=CC=C%12)NC(C%13=CC=CC=C%13)=O)=O)C%11

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Taxol Janelia Fluor® 646

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 28.07 20

Preparing Stock Solutions for Taxol Janelia Fluor® 646

The following data is based on the product molecular weight 1403.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 3.56 mL 17.81 mL 35.62 mL
1 mM 0.71 mL 3.56 mL 7.12 mL
2 mM 0.36 mL 1.78 mL 3.56 mL
10 mM 0.07 mL 0.36 mL 0.71 mL

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Product Datasheets for Taxol Janelia Fluor® 646

References for Taxol Janelia Fluor® 646

References are publications that support the biological activity of the product.

If you know of a relevant reference for Taxol Janelia Fluor® 646, please let us know.

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Keywords: Taxol Janelia Fluor 646, Taxol Janelia Fluor 646 supplier, red, fluorescent, taxol, derivative, cytoskeletal, probes, microtubules, fluorogenic, Organelle, and, Cell, Structure, Stains, Microtubule, Probes, 6266, Tocris Bioscience

1 Citation for Taxol Janelia Fluor® 646

Citations are publications that use Tocris products. Selected citations for Taxol Janelia Fluor® 646 include:

Lemaître et al (2021) Capturing T lymphocytes' dynamic interactions with human neural cells using time-lapse microscopy. Front.Immunol. 12 PMID: 33968073

Do you know of a great paper that uses Taxol Janelia Fluor® 646 from Tocris? Please let us know.

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Protocols for Taxol Janelia Fluor® 646

The following protocol features additional information for the use of Taxol Janelia Fluor® 646 (Cat. No. 6266).

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Fluorescent Dyes and Probes Research Product Guide

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