Taxol Janelia Fluor® 646

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Cat.No. 6266 - Taxol Janelia Fluor 646 | C79H82N4O18Si
Description: Red fluorescent taxol derivative
Chemical Name: 2-(3-(Azetidin-1-ium-1-ylidene)-7-(azetidin-1-yl)-5,5-dimethyl-3,5-dihydrodibenzo[b,e]silin-10-yl)-4-(((2S)-1-(((2aR,4S,4aS,6R,9S,11S,12S,12bS)-6,12b-diacetoxy-9-(((2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl)oxy)-12-(benzoyloxy)-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-4-yl)oxy)-1-oxopropan-2-yl)carbamoyl)benzoate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Protocols (1)
Literature (1)

Biological Activity

Red fluorescent taxol derivative for direct imaging of the microtubule cytoskeleton. Fluorogenic: fluoresces only once bound to microtubules, enabling hassle-free no-wash experiments. Protocol available. Excitation maximum = 646 nm; emission maximum = 664 nm.

Licensing Information

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus

Application of Taxol Janelia Fluor® 646 dye on COS7 cells

Taxol Janelia Fluor® 646 Dye-labeled COS7 cells

Application of Taxol Janelia Fluor® 646, dye on COS7 cells; COS7 cells were labeled with 3 µM Taxol Janelia Fluor® 646 for one hour at 37°C. Images were taken on a Leica TCS SP8 Confocal Laser Scanning Microscope.

All images kindly provided by Prof. Christian Soeller, University of Exeter; acquired by Evelina Lucinskaite, Anna Meletiou and Alexander Clowsley.

Optical Data for Taxol Janelia Fluor® 646

λabs 655 nm
λem 671 nm

Technical Data

M. Wt 1403.62
Formula C79H82N4O18Si
Storage Store at -20°C
Purity ≥98% (HPLC)
Smiles O=C(C)O[C@]12C([C@@]3(C)[C@@H](OC([C@H](C)NC(C4=CC=C(C([O-])=O)C(C5=C(C=C/6)C([Si](C)(C)C7=C5C=CC(N8CCC8)=C7)=CC6=[N+]9CCC\9)=C4)=O)=O)C[C@H]1OC2)[C@H](OC(C%10=CC=CC=C%10)=O)[C@@]%11(O)C(C)(C)C([C@@H](OC(C)=O)C3=O)=C(C)[C@@H](OC([C@H](O)[C@H](C%12=CC=CC=C%12)NC(C%13=CC=CC=C%13)=O)=O)C%11

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.07 20

Preparing Stock Solutions

The following data is based on the product molecular weight 1403.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 3.56 mL 17.81 mL 35.62 mL
1 mM 0.71 mL 3.56 mL 7.12 mL
2 mM 0.36 mL 1.78 mL 3.56 mL
10 mM 0.07 mL 0.36 mL 0.71 mL

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References

References are publications that support the biological activity of the product.

If you know of a relevant reference for Taxol Janelia Fluor® 646, please let us know.

Keywords: Taxol Janelia Fluor 646, Taxol Janelia Fluor 646 supplier, red, fluorescent, taxol, derivative, cytoskeletal, probes, microtubules, fluorogenic, Organelle, and, Cell, Structure, Stains, 6266, Tocris Bioscience

Citations for Taxol Janelia Fluor® 646

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Protocols for Taxol Janelia Fluor® 646

The following protocol features additional information for the use of Taxol Janelia Fluor® 646 (Cat. No. 6266).

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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