Taxol Janelia Fluor® 526

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Cat.No. 7315 - Taxol Janelia Fluor 526 | C73H74F6N4O17.CF3CO2H | CAS No. 2410613-93-1
Description: Green fluorescent taxol derivative; probe for microtubule staining
Alternative Names: Janelia Fluor 526-TXL
Chemical Name: 4-((8-(((1S,2R)-3-(((2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-12-(benzoyloxy)-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-9-yl)oxy)-2-hydroxy-3-oxo-1-phenylpropyl)amino)-8-oxooctyl)carbamoyl)-2-(3-(3,3-difluoroazetidin-1-ium-1-ylidene)-6-(3,3-difluoroazetidin-1-yl)-2,7-difluoro-3H-xanthen-9-yl)benzoate trifluoroacetate
Purity: ≥85% (HPLC)
Literature (1)

Biological Activity for Taxol Janelia Fluor® 526

Taxol Janelia Fluor® 526 is a fluorogenic, green fluorescent taxol derivative for direct imaging of the microtubule cytoskeleton. Taxol Janelia Fluor® 526 is fluorogenic: it fluoresces only once bound to microtubules, enabling hassle-free no-wash experiments. Excitation maximum = 531 nm; emission maximum = 548 nm.

Licensing Information

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus

Optical Data for Taxol Janelia Fluor® 526

Taxol Janelia Fluor<sup>®</sup> 526 Dye Spectra
Emission Color Green
λabs 531 nm
λem 549 nm
Extinction Coefficient (ε) 118000 M-1cm-1
Quantum Yield (φ) 0.87
Application STED, confocal microscopy, super-resolution microscopy

Technical Data for Taxol Janelia Fluor® 526

M. Wt 1507.42
Formula C73H74F6N4O17.CF3CO2H
Storage Store at -20°C
Purity ≥85% (HPLC)
CAS Number 2410613-93-1
Smiles [H][C@@]12C[C@@H]([C@]3(C([C@@H](C4=C([C@@H](OC([C@@H]([C@H](C5=CC=CC=C5)NC(CCCCCCCNC(C6=CC(C7=C8C=C(/C(C=C8OC9=C7C=C(C(N%10CC(F)(C%10)F)=C9)F)=[N+]%11CC(F)(C/%11)F)F)=C(C([O-])=O)C=C6)=O)=O)O)=O)C[C@@]([C@H]([C@@]3([C@]1(OC(C)=O)CO2)[H])OC(C%12=CC=CC=C%12)=O)(C4(C)C)O)C)O)=O)C)O.O=C(O[H])C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Taxol Janelia Fluor® 526

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 15.07 10

Preparing Stock Solutions for Taxol Janelia Fluor® 526

The following data is based on the product molecular weight 1507.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 6.63 mL 33.17 mL 66.34 mL
0.5 mM 1.33 mL 6.63 mL 13.27 mL
1 mM 0.66 mL 3.32 mL 6.63 mL
5 mM 0.13 mL 0.66 mL 1.33 mL

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Product Datasheets for Taxol Janelia Fluor® 526

Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service

References for Taxol Janelia Fluor® 526

References are publications that support the biological activity of the product.

Zheng et al (2019) Rational design of fluorogenic and spontaneously blinking labels for super-resolution imaging. ACS Cent.Sci. 5 1602 PMID: 31572787

If you know of a relevant reference for Taxol Janelia Fluor® 526, please let us know.

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Keywords: Taxol Janelia Fluor 526, Taxol Janelia Fluor 526 supplier, Fluorogenic, green, fluorescent, taxol, microtubule, cytoskeleton, stains, probes, dyes, Janelia, Fluor, 526-TXL, Microtubule, Probes, 7315, Tocris Bioscience

Citations for Taxol Janelia Fluor® 526

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Literature in this Area

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