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Submit ReviewTAN 452 is a potent and selective peripherally acting δ opioid antagonist; Ki values are 0.47, 5.31 and 36.56 nM at hDOR, hKOR, and hMOR, respectively. Kb values are 0.21, 7.18 and 9.43 nM, respectively. Attenuates morphine-induced side effects in vivo. Antianalgesic.
M. Wt | 486.56 |
Formula | C29H30N2O5 |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 892039-23-5 |
PubChem ID | 57614240 |
InChI Key | JOJGLAWHRDFWNQ-KFDULEKRSA-N |
Smiles | [H][C@@]12OC3=C(C=CC4=C3[C@@]15CCN([C@](C4)([C@@]5(CC6=C2NC7=CC(C(OCC)=O)=CC=C67)O)[H])CC8CC8)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 48.66 | 100 | |
ethanol | 48.66 | 100 |
The following data is based on the product molecular weight 486.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.06 mL | 10.28 mL | 20.55 mL |
5 mM | 0.41 mL | 2.06 mL | 4.11 mL |
10 mM | 0.21 mL | 1.03 mL | 2.06 mL |
50 mM | 0.04 mL | 0.21 mL | 0.41 mL |
References are publications that support the biological activity of the product.
Lattanzi et al (2018) In vitro and in vivo pharmacological activities of 14-O-phenylpropyloxymorphone, a potent mixed mu/delta/kappa-opioid receptor agonist with reduced constipation in mice. Front.Pharmacol. 9 10.3389/fphar.2018.0 PMID: 30233377
If you know of a relevant reference for TAN 452, please let us know.
Keywords: TAN 452, TAN 452 supplier, TAN452, Potent, selective, peripherally, acting, delta, opioid, antagonists, antagonism, antianalgesic, Delta, Opioid, Receptors, 6729, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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