TAME hydrochloride

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Cat.No. 4506 - TAME hydrochloride | C14H22N4O4S.HCl | CAS No. 1784-03-8
Description: Ubiquitin ligase APC/C inhibitor; promotes Cdc20 autoubiquitination
Chemical Name: N2-[(4-Methylphenyl)sulfonyl]-L-arginine methyl ester hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Competitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C); promotes Cdc20 autoubiquitination. Inhibits cyclin proteolysis in mitotic Xenopus oocyte extracts (IC50 = 12 μM) and blocks cyclin degradation in interphase extract.

Technical Data

M. Wt 378.87
Formula C14H22N4O4S.HCl
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 1784-03-8
PubChem ID 2723792
InChI Key JIQFFACVQXXHMY-YDALLXLXSA-N
Smiles NC(NCCC[C@H](NS(C1=CC=C(C)C=C1)(=O)=O)C(OC)=O)=N.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 37.89 100
DMSO 37.89 100

Preparing Stock Solutions

The following data is based on the product molecular weight 378.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.64 mL 13.2 mL 26.39 mL
5 mM 0.53 mL 2.64 mL 5.28 mL
10 mM 0.26 mL 1.32 mL 2.64 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Zeng et al (2010) Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell. 18 382 PMID: 20951947

Zeng & King (2012) An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nat.Chem.Biol. 8 383 PMID: 22366722


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1 Citation for TAME hydrochloride

Citations are publications that use Tocris products. Selected citations for TAME hydrochloride include:

Coles et al (2015) KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms. PLoS Genet 11 e1005525 PMID: 26439735


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Literature in this Area

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