TAME hydrochloride

Discontinued Product

TAME hydrochloride (Cat. No. 4506) has been withdrawn from sale for commercial reasons.
Description: Ubiquitin ligase APC/C inhibitor; promotes Cdc20 autoubiquitination
Chemical Name: N2-[(4-Methylphenyl)sulfonyl]-L-arginine methyl ester hydrochloride
Purity: ≥99% (HPLC)
Citations (1)
Literature (3)

Biological Activity for TAME hydrochloride

TAME hydrochloride is a competitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C); promotes Cdc20 autoubiquitination. Inhibits cyclin proteolysis in mitotic Xenopus oocyte extracts (IC50 = 12 μM) and blocks cyclin degradation in interphase extract.

Technical Data for TAME hydrochloride

M. Wt 378.87
Formula C14H22N4O4S.HCl
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 1784-03-8
PubChem ID 2723792
Smiles NC(NCCC[C@H](NS(C1=CC=C(C)C=C1)(=O)=O)C(OC)=O)=N.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for TAME hydrochloride

References for TAME hydrochloride

References are publications that support the biological activity of the product.

Zeng et al (2010) Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell. 18 382 PMID: 20951947

Zeng & King (2012) An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nat.Chem.Biol. 8 383 PMID: 22366722

View Related Products by Product Action

View all Ubiquitin E3 Ligase Inhibitors

Keywords: TAME hydrochloride, TAME hydrochloride supplier, ubiquitin, ligase, anaphase-promoting, complex/cyclosome, APC, inhibits, inhibitors, competitive, mitotic, arrest, cyclin, stabilization, TAME, hydrochloride, HCl, Ubiquitin, E3, Ligases, Mitosis, 4506, Tocris Bioscience

1 Citation for TAME hydrochloride

Citations are publications that use Tocris products. Selected citations for TAME hydrochloride include:

Coles et al (2015) KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms. PLoS Genet 11 e1005525 PMID: 26439735

Reviews for TAME hydrochloride

There are currently no reviews for this product. Be the first to review TAME hydrochloride and earn rewards!

Have you used TAME hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Targeted Protein Degradation Research Product Guide

Targeted Protein Degradation Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Ubiquitin-Proteasome System Proteins
  • Assays for Protein Degradation
Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia