Talniflumate

Pricing Availability Delivery Time Qty
Cat.No. 2510 - Talniflumate | C21H13F3N2O4 | CAS No. 66898-62-2
Description: CaCC blocker and Cl-/HCO3- exchange inhibitor
Chemical Name: 2-[[3-(Trifluoromethyl)phenyl]amino]-1,3-dihydro-3-oxo-1-isobenzofuranyl 3-pyridinecarboxylic acid ester
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Calcium-activated chloride channel (CaCC) (hCLCA1/mCLCA3) blocker; reduces mucin synthesis and release in cell culture and animal models. Possesses anti-inflammatory actions via inhibition of cyclooxygenases and inhibits Cl-/HCO3- exchanger activity. Increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.

Compound Libraries

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Technical Data

M. Wt 414.34
Formula C21H13F3N2O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 66898-62-2
PubChem ID 48229
InChI Key ANMLJLFWUCQGKZ-UHFFFAOYSA-N
Smiles FC(F)(F)C1=CC(NC2=NC=CC=C2C(=O)OC2OC(=O)C3=CC=CC=C23)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.36 25

Preparing Stock Solutions

The following data is based on the product molecular weight 414.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.07 mL 24.13 mL
5 mM 0.48 mL 2.41 mL 4.83 mL
10 mM 0.24 mL 1.21 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Walker et al (2006) Talniflumate increases survival in a cystic fibrosis mouse model of distal intestinal obstructuve syndrome. J.Pharmacol.Exp.Ther. 317 275 PMID: 16354791

Sanchez et al (1982) Action of a non-steroidal anti-inflammatory drug on gastric mucosa of rats. J.Appl.Toxicol. 2 42 PMID:

Knight (2004) Talniflumate (Genaera). Curr.Opin.Invest.Drugs 5 557 PMID:


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View Related Products by Product Action

View all Calcium-activated Chloride Channel Blockers

Keywords: Cyclooxygenase inhibitors inhibits chloride channels blockers Chloride hCLCA1/mCLCA3 COX Oxygenases Oxidases Cl-/HCO3- exchangers CaCC calcium-activated Ca2+-Activated Chloride Channels

Citations for Talniflumate

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Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Talniflumate

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.

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