Talniflumate

Discontinued Product

Talniflumate (Cat. No. 2510) has been withdrawn from sale for commercial reasons.
Cat.No. 2510 - Talniflumate | C21H13F3N2O4 | CAS No. 66898-62-2
Description: CaCC blocker and Cl-/HCO3- exchange inhibitor
Chemical Name: 2-[[3-(Trifluoromethyl)phenyl]amino]-1,3-dihydro-3-oxo-1-isobenzofuranyl 3-pyridinecarboxylic acid ester
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (4)
Pathways (1)

Biological Activity for Talniflumate

Talniflumate is a calcium-activated chloride channel (CaCC) (hCLCA1/mCLCA3) blocker; reduces mucin synthesis and release in cell culture and animal models. Possesses anti-inflammatory actions via inhibition of cyclooxygenases and inhibits Cl-/HCO3- exchanger activity. Increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.

Technical Data for Talniflumate

M. Wt 414.34
Formula C21H13F3N2O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 66898-62-2
PubChem ID 48229
InChI Key ANMLJLFWUCQGKZ-UHFFFAOYSA-N
Smiles FC(F)(F)C1=CC(NC2=NC=CC=C2C(=O)OC2OC(=O)C3=CC=CC=C23)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Talniflumate

References are publications that support the biological activity of the product.

Walker et al (2006) Talniflumate increases survival in a cystic fibrosis mouse model of distal intestinal obstructuve syndrome. J.Pharmacol.Exp.Ther. 317 275 PMID: 16354791

Sanchez et al (1982) Action of a non-steroidal anti-inflammatory drug on gastric mucosa of rats. J.Appl.Toxicol. 2 42

Knight (2004) Talniflumate (Genaera). Curr.Opin.Invest.Drugs 5 557

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View all Calcium-activated Chloride Channel Blockers

Keywords: Talniflumate, Talniflumate supplier, Cyclooxygenase, inhibitors, inhibits, chloride, channels, blockers, Chloride, hCLCA1/mCLCA3, COX, Oxygenases, Oxidases, Cl-/HCO3-, exchangers, CaCC, calcium-activated, Ca2+-Activated, Channels, 2510, Tocris Bioscience

Citations for Talniflumate

Citations are publications that use Tocris products.

Currently there are no citations for Talniflumate.

Reviews for Talniflumate

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Activity evaluation of Talniflumate carried out..
By Anonymous on 08/26/2019
Species: Human

Activity evaluation of Talniflumate carried out. Human pancreatic cancer cell line MIA PaCa and BxPC-3 were used.

Cells were were incubated with different concentrations of Talniflumate (50, 100, 150 and 200 mkM), gefitinib and the combination of talniflumate and gefitinib for 24h.


Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Pathways for Talniflumate

Apoptosis

Apoptosis Signaling Pathway

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