Talampanel

Pricing Availability   Qty
Description: Non-competitive non-NMDA iGluR antagonist
Alternative Names: GYKI 53773,LY 300164
Chemical Name: (8R)-7-Acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity for Talampanel

Talampanel is a non-competitive AMPA/kainate receptor antagonist that displays 2.3-3-fold more potent activity than GYKI 52466 (Cat. No. 1454). Potentiates the anticonvulsive activity of antiepileptic drugs in animal models of seizures. Orally active.

Compound Libraries for Talampanel

Talampanel is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Talampanel

M. Wt 337.37
Formula C19H19N3O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 161832-65-1
PubChem ID 164509
InChI Key JACAAXNEHGBPOQ-LLVKDONJSA-N
Smiles NC(C=C4)=CC=C4C1=NN(C(C)=O)[C@H](C)CC2=C1C=C(OCO3)C3=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Talampanel

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.74 100

Preparing Stock Solutions for Talampanel

The following data is based on the product molecular weight 337.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.82 mL 29.64 mL
5 mM 0.59 mL 2.96 mL 5.93 mL
10 mM 0.3 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for Talampanel

References are publications that support the biological activity of the product.

Czuczwar et al (1998) LY 300164, a novel antagonist of AMPA/kainate receptors, potentiates the anticonvulsive activity of antiepileptic drugs. Eur.J.Pharmacol. 359 103 PMID: 9832379

Borowicz et al (2000) The AMPA/kainate receptor antagonist, LY 300164, increases the anticonvulsant effects of D.pam. Naunyn-Schmied.Arch.Pharmacol. 361 629 PMID: 10882038

Belayev et al (2001) Talampanel, a novel noncompetitive AMPA antagonist, is neuroprotective after traumatic brain injury in rats. J.Neurotrauma 18 1031 PMID: 11686490


If you know of a relevant reference for Talampanel, please let us know.

View Related Products by Product Action

View all AMPA Receptor Antagonists

Keywords: Talampanel, Talampanel supplier, GYKI53773, LY300164, non-competitive, AMPA/Kainate, antagonists, Glutamate, Receptors, iGlur, Ionotropic, GYKI, 53773, LY, 300164, AMPA, Kainate, 5032, Tocris Bioscience

Citations for Talampanel

Citations are publications that use Tocris products.

Currently there are no citations for Talampanel. Do you know of a great paper that uses Talampanel from Tocris? Please let us know.

Reviews for Talampanel

There are currently no reviews for this product. Be the first to review Talampanel and earn rewards!

Have you used Talampanel?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.