T2AA

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Cat.No. 4723 - T2AA | CAS No. 1380782-27-3
Description: PCNA inhibitor
Chemical Name: (βS)-β-Amino-4-(4-hydroxyphenoxy)-3,5-diiodobenzenpropanol
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews (1)
Literature

Biological Activity

Proliferating cell nuclear antigen (PCNA) inhibitor; inhibits PCNA/PIP-box peptide interaction (IC50 ~1 μM). Causes DNA replication stress by stalling DNA replication forks. Inhibits PCNA interaction with DNA polymerase δ and arrests cell growth in S-phase. Suppresses cancer cell growth.

Licensing Information

Sold under license from St. Jude Childrens Research Hospital

Technical Data

M. Wt 511.09
Formula C15H15I2NO3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1380782-27-3
PubChem ID 71185540
InChI Key NKOSKXJRVWVXRI-JTQLQIEISA-N
Smiles IC1=C(OC2=CC=C(O)C=C2)C(I)=CC(C[C@H](N)CO)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.11 100

Preparing Stock Solutions

The following data is based on the product molecular weight 511.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.96 mL 9.78 mL 19.57 mL
5 mM 0.39 mL 1.96 mL 3.91 mL
10 mM 0.2 mL 0.98 mL 1.96 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

Molarity Calculator

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References

References are publications that support the biological activity of the product.

Punchihewa et al (2012) Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J.Biol.Chem. 287 14289 PMID: 22383522


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Keywords: T2AA, T2AA supplier, Proliferating, cell, nuclear, antigen, PCNA, inhibitors, inhibits, DNA, replication, forks, DNA,, RNA, and, Protein, Synthesis, RNA/DNA, Polymerase, 4723, Tocris Bioscience

Citations for T2AA

Citations are publications that use Tocris products.

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Reviews for T2AA

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T2AA completely kills melanoma cell line at micromolar concentrations: Excellent publishable, performed ideally.
By Anonymous on 02/07/2019
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: SK-MEL-28

Used for killing assay for in vitro cell culture. Cells were cultured for 24 hours before the addition of the compound into the media at low micromolar concentrations (indicated by the arrow).

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis