T2AA

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Cat.No. 4723 - T2AA | CAS No. 1380782-27-3
Description: PCNA inhibitor
Chemical Name: (βS)-β-Amino-4-(4-hydroxyphenoxy)-3,5-diiodobenzenpropanol
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Proliferating cell nuclear antigen (PCNA) inhibitor; inhibits PCNA/PIP-box peptide interaction (IC50 ~1 μM). Causes DNA replication stress by stalling DNA replication forks. Inhibits PCNA interaction with DNA polymerase δ and arrests cell growth in S-phase. Suppresses cancer cell growth.

Licensing Information

Sold under license from St. Jude Childrens Research Hospital

Technical Data

M. Wt 511.09
Formula C15H15I2NO3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1380782-27-3
PubChem ID 71185540
InChI Key NKOSKXJRVWVXRI-JTQLQIEISA-N
Smiles IC1=C(OC2=CC=C(O)C=C2)C(I)=CC(C[C@H](N)CO)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 5.11 10mM with gentle warming
DMSO 51.11 100

Preparing Stock Solutions

The following data is based on the product molecular weight 511.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.96 mL 9.78 mL 19.57 mL
5 mM 0.39 mL 1.96 mL 3.91 mL
10 mM 0.2 mL 0.98 mL 1.96 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Punchihewa et al (2012) Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J.Biol.Chem. 287 14289 PMID: 22383522


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Keywords: T2AA, supplier, Proliferating, cell, nuclear, antigen, PCNA, inhibitors, inhibits, DNA, replication, forks, DNA,, RNA, and, Protein, Synthesis, Tocris Bioscience

Citations for T2AA

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for T2AA

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