Sulfidefluor 7 AM

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Cat.No. 4943 - Sulfidefluor 7 AM | C31H23N7O12 | CAS No. 1416872-50-8
Description: H2S fluorescent probe
Chemical Name: N-[2-[(Acetyloxy)methoxy]-2-oxoethyl]-N-[(3',6'-diazido-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)carbonyl]glycine (acetyloxy)methyl ester
Datasheet
Citations
Literature

Biological Activity

Reported to be a hydrogen sulphide (H2S) fluorescent probe. Contains an acetoxymethyl ester, which enhances cell permeability and is hydrolyzed inside the cell to trap the probe. Used to visualize VEGF-induced H2S production in human umbilical vein endothelial cells (HUVECS). Excitation wavelength ~ 495 nm; emission maximum ~ 520 nm.

Licensing Information

Sold under license from the Regents of the University of California

Technical Data

M. Wt 685.55
Formula C31H23N7O12
Storage Store at -20°C
CAS Number 1416872-50-8
PubChem ID 89306941
InChI Key QIAZHSBWGCYJGQ-UHFFFAOYSA-N
Smiles O=C(O1)C2=C(C=CC(C(N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)=O)=C2)C31C4=CC=C(N=[N+]=[N-])C=C4OC5=C3C=CC(N=[N+]=[N-])=C5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 13.71 20

Preparing Stock Solutions

The following data is based on the product molecular weight 685.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.46 mL 7.29 mL 14.59 mL
5 mM 0.29 mL 1.46 mL 2.92 mL
10 mM 0.15 mL 0.73 mL 1.46 mL
50 mM 0.03 mL 0.15 mL 0.29 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lin et al (2013) Cell-trappable fluorescent probes for endogenous hydrogen sulfide signaling and imaging H2O2-dependent H2S production. Proc.Natl.Acad.Sci.USA. 110 7131 PMID: 23589874

Lippert et al (2011) Reaction-based fluorescent probes for selective imaging of hydrogen sulfide in living cells. J.Am.Chem.Soc. 133 10078 PMID: 21671682


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Keywords: hydrogen sulphide H2S fluorescent probe Fluorescent Probes

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New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

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  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

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