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Competitive inhibitor of the p53-MDM2/MDMX interaction (Kd = 493 nM for MDM2). Kills tumor cells in a p53-dependent manner.
Sold under license from the University of Maryland, Baltimore
(Modifications: Disulfide bridges: 1-20, 6-25,10-27)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Li et al (2008) Turning a scorpion toxin into an antitumor miniprotein. J.Am.Chem.Soc. 130 13546 PMID: 18798622
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Keywords: Stoppin 2, Stoppin 2 supplier, Stoppin-2, p53-MDM2, interaction, inhibitors, inhibits, antitumor, antitumour, MDM2, MDMX, p53-MDMX, Ligases, Transcription, Factors, Ubiquitin, E3, p53, 4851, Tocris Bioscience
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Literature in this Area
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Targeted Protein Degradation Research Product Guide
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