Discontinued ProductUnfortunately Stoppin 2 (Cat. No. 4851) has been withdrawn from sale for commercial reasons.
Competitive inhibitor of the p53-MDM2/MDMX interaction (Kd = 493 nM for MDM2). Kills tumor cells in a p53-dependent manner.
Sold under license from the University of Maryland, Baltimore
(Modifications: Disulfide bridges: 1-20, 6-25,10-27)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 3313.03. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.3 mL||1.51 mL||3.02 mL|
|5 mM||0.06 mL||0.3 mL||0.6 mL|
|10 mM||0.03 mL||0.15 mL||0.3 mL|
|50 mM||0.01 mL||0.03 mL||0.06 mL|
References are publications that support the products' biological activity.
Li et al (2008) Turning a scorpion toxin into an antitumor miniprotein. J.Am.Chem.Soc. 130 13546 PMID: 18798622
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Keywords: Stoppin 2, supplier, Stoppin-2, p53-MDM2, interaction, inhibitors, inhibits, antitumor, antitumour, MDM2, MDMX, p53-MDMX, Ligases, Transcription, Factors, Ubiquitin, E3, Ligases, p53, Ubiquitin, E3, Ligases, Tocris Bioscience
Citations for Stoppin 2
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Currently there are no citations for Stoppin 2.
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Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.