Stoppin 2

Discontinued Product

Stoppin 2 (Cat. No. 4851) has been withdrawn from sale for commercial reasons.
Description: Competitive p53-MDM2/MDMX interaction inhibitor
Literature (3)

Biological Activity for Stoppin 2

Competitive inhibitor of the p53-MDM2/MDMX interaction (Kd = 493 nM for MDM2). Kills tumor cells in a p53-dependent manner.

Licensing Information

Sold under license from the University of Maryland, Baltimore

Technical Data for Stoppin 2

M. Wt 3313.03
Formula C141H223N47O32S7

(Modifications: Disulfide bridges: 1-20, 6-25,10-27)

Storage Store at -20°C
CAS Number 1069134-09-3
Smiles [H]N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC1=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC4=C1C=CC=C4)C(=O)N[C@@H](CCCCN)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Stoppin 2

References are publications that support the biological activity of the product.

Li et al (2008) Turning a scorpion toxin into an antitumor miniprotein. J.Am.Chem.Soc. 130 13546 PMID: 18798622

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Keywords: Stoppin 2, Stoppin 2 supplier, Stoppin-2, p53-MDM2, interaction, inhibitors, inhibits, antitumor, antitumour, MDM2, MDMX, p53-MDMX, Ligases, Transcription, Factors, Ubiquitin, E3, p53, 4851, Tocris Bioscience

Citations for Stoppin 2

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Currently there are no citations for Stoppin 2.

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