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Competitive inhibitor of the p53-MDM2/MDMX interaction (Kd = 493 nM for MDM2). Kills tumor cells in a p53-dependent manner.
Sold under license from the University of Maryland, Baltimore
(Modifications: Disulfide bridges: 1-20, 6-25,10-27)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Li et al (2008) Turning a scorpion toxin into an antitumor miniprotein. J.Am.Chem.Soc. 130 13546 PMID: 18798622
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Keywords: Stoppin 2, Stoppin 2 supplier, Stoppin-2, p53-MDM2, interaction, inhibitors, inhibits, antitumor, antitumour, MDM2, MDMX, p53-MDMX, Ligases, Transcription, Factors, Ubiquitin, E3, p53, 4851, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Targeted Protein Degradation Research Product Guide
This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:
- Active Degraders (e.g. PROTACs)
- Degrader Building Blocks
- Custom Degrader Services
- UPS Proteins and Assays
- Assays for Protein Degradation
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed.