Stoppin 2

Discontinued Product

Unfortunately Stoppin 2 (Cat. No. 4851) has been withdrawn from sale for commercial reasons.
Cat.No. 4851 - Stoppin 2 | Cys-Tyr-Ser-Phe-Asp-Cys-Leu-Trp-Lys-Cys-Leu-Ala-Met-Gly-Phe-Arg-Arg-Gly-Lys-Cys-Arg-Arg-Arg-Lys-Cys-Lys-Cys | CAS No. 1069134-09-3
Description: Competitive p53-MDM2/MDMX interaction inhibitor
Datasheet
Citations
Reviews
Literature

Biological Activity

Competitive inhibitor of the p53-MDM2/MDMX interaction (Kd = 493 nM for MDM2). Kills tumor cells in a p53-dependent manner.

Licensing Information

Sold under license from the University of Maryland, Baltimore

Technical Data

M. Wt 3313.03
Formula C141H223N47O32S7
Sequence CYSFDCLWKCLAMGFRRGKCRRRKCKC

(Modifications: Disulfide bridges: 1-20, 6-25,10-27)

Storage Store at -20°C
CAS Number 1069134-09-3
Smiles [H]N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC1=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC4=C1C=CC=C4)C(=O)N[C@@H](CCCCN)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 3313.03. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.3 mL 1.51 mL 3.02 mL
5 mM 0.06 mL 0.3 mL 0.6 mL
10 mM 0.03 mL 0.15 mL 0.3 mL
50 mM 0.01 mL 0.03 mL 0.06 mL

Molarity Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Li et al (2008) Turning a scorpion toxin into an antitumor miniprotein. J.Am.Chem.Soc. 130 13546 PMID: 18798622

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Citations for Stoppin 2

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Currently there are no citations for Stoppin 2.

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Literature in this Area

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