SR 3677 dihydrochloride

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Cat.No. 3667 - SR 3677 dihydrochloride | C22H24N4O4.2HCl | CAS No. 1781628-88-3
Description: Potent, selective Rho-kinase (ROCK) inhibitor
Chemical Name: N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl-2,3-dihydro-1,4-benzodioxin-2-carboxamide dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (6)

Biological Activity

Potent and selective Rho-kinase inhibitor (IC50 values are 3 and 56 nM for ROCK-II and ROCK-I respectively).

Compound Libraries

SR 3677 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 481.37
Formula C22H24N4O4.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1781628-88-3
PubChem ID 90255168
InChI Key INVVXEKRUDMEBE-UHFFFAOYSA-N
Smiles O=C(C3COC(C=CC=C4)=C4O3)NC1=CC=C(C2=CNN=C2)C=C1OCCN(C)C.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 44.49 100
DMSO 44.49 100

Preparing Stock Solutions

The following data is based on the product molecular weight 481.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.08 mL 10.39 mL 20.77 mL
5 mM 0.42 mL 2.08 mL 4.15 mL
10 mM 0.21 mL 1.04 mL 2.08 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Feng et al (2008) Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J.Med.Chem. 51 6642 PMID: 18834107


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View all Rho-Kinases Inhibitors

Keywords: SR 3677 dihydrochloride, SR 3677 dihydrochloride supplier, potent, selective, Rho-kinase, ROCK, inhibitors, inhibits, Rho-associated, coiled-coil, kinases, stem, cells, SR3677, hydrochloride, Rho-kinases, Stem, Cell, Signaling, 3667, Tocris Bioscience

2 Citations for SR 3677 dihydrochloride

Citations are publications that use Tocris products. Selected citations for SR 3677 dihydrochloride include:

El-Sayed et al (2014) P2Y2 nucleotide receptor activation enhances the aggregation and self-organization of dispersed salivary epithelial cells. Front Microbiol 307 C83 PMID: 24760984

Lotz-Jenne et al (2016) A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor. Oncotarget 7 25983 PMID: 27036020


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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