Spiperone hydrochloride

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Cat.No. 0995 - Spiperone hydrochloride | C23H26FN3O2.HCl | CAS No. 2022-29-9
Description: 5-HT2A antagonist. Also D2-like antagonist
Chemical Name: 8-[4-(4-Fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

5-HT2A serotonin and selective D2-like dopamine receptor antagonist (Ki values are 0.06, 0.6, 0.08, ~ 350, ~ 3500 nM for D2, D3, D4, D1 and D5 receptors respectively). Antipsychotic.

Technical Data

M. Wt 431.94
Formula C23H26FN3O2.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 2022-29-9
PubChem ID 11957687
InChI Key QUIKMLCZZMOBLH-UHFFFAOYSA-N
Smiles Cl.FC1=CC=C(C=C1)C(=O)CCCN1CCC2(CC1)N(CNC2=O)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.19 100

Preparing Stock Solutions

The following data is based on the product molecular weight 431.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.32 mL 11.58 mL 23.15 mL
5 mM 0.46 mL 2.32 mL 4.63 mL
10 mM 0.23 mL 1.16 mL 2.32 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165

Seeman and van Tol (1994) Dopamine receptor pharmacology. TiPS 15 264 PMID: 7940991

Merck Index 12 8903 PMID:


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Keywords: Spiperone hydrochloride, supplier, D2-like, antagonists, 5-HT2A, Dopamine, Non-Selective, Receptors, Serotonin, dopaminergic, 5-HT2A, Receptors, Non-selective, Dopamine, 5-HT2A, Receptors, Tocris Bioscience

3 Citations for Spiperone hydrochloride

Citations are publications that use Tocris products. Selected citations for Spiperone hydrochloride include:

Nickla et al (2010) Dopaminergic agonists that result in ocular growth inhibition also elicit transient increases in choroidal thickness in chicks. Exp Eye Res 91 715 PMID: 20801115

Zapata et al (2007) Regulation of dopamine transporter function and cell surface expression by D3 dopamine receptors. J Biol Chem 282 35842 PMID: 17923483

Meredith et al (2006) Dopamine targets cycling B cells independent of receptors/transporter for oxidative attack: Implications for non-Hodgkin's lymphoma. Proc Natl Acad Sci U S A 103 13485 PMID: 16938864


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