Spiperone hydrochloride

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Cat.No. 0995 - Spiperone hydrochloride | C23H26FN3O2.HCl | CAS No. 2022-29-9
Description: 5-HT2A antagonist; also D2-like antagonist
Chemical Name: 8-[4-(4-Fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (6)
Reviews
Literature (6)

Biological Activity

5-HT2A serotonin and selective D2-like dopamine receptor antagonist (Ki values are 0.06, 0.6, 0.08, ~ 350, ~ 3500 nM for D2, D3, D4, D1 and D5 receptors respectively). Antipsychotic.

Compound Libraries

Spiperone hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 431.94
Formula C23H26FN3O2.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 2022-29-9
PubChem ID 11957687
InChI Key QUIKMLCZZMOBLH-UHFFFAOYSA-N
Smiles Cl.FC1=CC=C(C=C1)C(=O)CCCN1CCC2(CC1)N(CNC2=O)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.19 100

Preparing Stock Solutions

The following data is based on the product molecular weight 431.94. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.32 mL 11.58 mL 23.15 mL
5 mM 0.46 mL 2.32 mL 4.63 mL
10 mM 0.23 mL 1.16 mL 2.32 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165

Seeman and van Tol (1994) DA receptor pharmacology. TiPS 15 264 PMID: 7940991

Merck Index 12 8903


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View all 5-HT2A Receptor Antagonists

Keywords: Spiperone hydrochloride, Spiperone hydrochloride supplier, D2-like, antagonists, 5-HT2A, Dopamine, Non-Selective, Receptors, Serotonin, dopaminergic, Non-selective, 0995, Tocris Bioscience

6 Citations for Spiperone hydrochloride

Citations are publications that use Tocris products. Selected citations for Spiperone hydrochloride include:

Zapata et al (2007) Regulation of DA transporter function and cell surface expression by D3 DA receptors. J Biol Chem 282 35842 PMID: 17923483

Baca et al (2013) Gene-environment interactions affect long-term depression (LTD) through changes in DA receptor affinity in Snap25 deficient mice. Brain Res 1532 85 PMID: 23939223

Titlow et al (2013) Pharmacological analysis of DA modulation in the Drosophila melanogaster larval heart. Physiol Rep 1 e00020 PMID: 24303109

Nickla et al (2010) DArgic agonists that result in ocular growth inhibition also elicit transient increases in choroidal thickness in chicks. Exp Eye Res 91 715 PMID: 20801115


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Literature in this Area

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