Spinorphin

Pricing Availability   Qty
Cat.No. 2931 - Spinorphin | Leu-Val-Val-Tyr-Pro-Trp-Thr | CAS No. 137201-62-8
Description: Enkephalin-degrading and ACE inhibitor
Datasheet
Citations
Reviews
Literature

Biological Activity

Endogenous peptide; inhibits enkephalin-degrading enzymes (aminopeptidase, dipeptidyl aminopeptidase III, neprilysin) and angiotensin-converting enzyme. Displays antinociceptive effects in mice.

Technical Data

M. Wt 877.05
Formula C45H64N8O10
Sequence LVVYPWT
Storage Desiccate at -20°C
CAS Number 137201-62-8
PubChem ID 3081832
InChI Key BXIFNVGZIMFBQB-DYDSHOKNSA-N
Smiles [H]N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Honda et al (2001) Spinorphin, an endogenous inhibitor of enkephalin-degrading enzymes, potentiates Leu-enkephalin-induced anti-allodynic and antinociceptive effects in mice. Jpn.J.Pharmacol. 87 261 PMID: 11829145

Liang et al (2001) The endogenous opioid spinorphin blocks fMet-Leu-Phe-induced neutrophil chemotaxis by acting as a specific antagonist at the N-formylpeptide receptor subtype FPR. J.Immunol. 167 6609 PMID: 11714831


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Keywords: Spinorphin, Spinorphin supplier, Potent, P2X3, antagonists, Enkephalin-degrading, ACE, inhibitors, inhibits, Receptors, Purinergic, purinoceptors, Angiotensin-Converting, Enzyme, Proteinases, Proteases, Other, 2931, Tocris Bioscience

Citations for Spinorphin

Citations are publications that use Tocris products.

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Literature in this Area

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Cardiovascular

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