Endogenous peptide; inhibits enkephalin-degrading enzymes (aminopeptidase, dipeptidyl aminopeptidase III, neprilysin) and angiotensin-converting enzyme. Displays antinociceptive effects in mice.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 877.05. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.14 mL||5.7 mL||11.4 mL|
|5 mM||0.23 mL||1.14 mL||2.28 mL|
|10 mM||0.11 mL||0.57 mL||1.14 mL|
|50 mM||0.02 mL||0.11 mL||0.23 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Honda et al (2001) Spinorphin, an endogenous inhibitor of enkephalin-degrading enzymes, potentiates Leu-enkephalin-induced anti-allodynic and antinociceptive effects in mice. Jpn.J.Pharmacol. 87 261 PMID: 11829145
Liang et al (2001) The endogenous opioid spinorphin blocks fMet-Leu-Phe-induced neutrophil chemotaxis by acting as a specific antagonist at the N-formylpeptide receptor subtype FPR. J.Immunol. 167 6609 PMID: 11714831
If you know of a relevant reference for Spinorphin, please let us know.
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Keywords: Potent P2X3 antagonists Enkephalin-degrading ACE inhibitors inhibits Receptors Purinergic purinoceptors Angiotensin-Converting Enzyme Proteinases Proteases Angiotensin-Converting Enzyme
Citations for Spinorphin
Citations are publications that use Tocris products.
Currently there are no citations for Spinorphin. Do you know of a great paper that uses Spinorphin from Tocris? If so please let us know.