Discontinued Product

Spinorphin (Cat. No. 2931) has been withdrawn from sale for commercial reasons.
Description: Enkephalin-degrading and ACE inhibitor

Biological Activity for Spinorphin

Spinorphin is an endogenous peptide; inhibits enkephalin-degrading enzymes (aminopeptidase, dipeptidyl aminopeptidase III, neprilysin) and angiotensin-converting enzyme. Displays antinociceptive effects in mice.

Technical Data for Spinorphin

M. Wt 877.05
Formula C45H64N8O10
Sequence LVVYPWT
Storage Desiccate at -20°C
CAS Number 137201-62-8
PubChem ID 3081832
Smiles [H]N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Spinorphin

Certificate of Analysis / Product Datasheet
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References for Spinorphin

References are publications that support the biological activity of the product.

Honda et al (2001) Spinorphin, an endogenous inhibitor of enkephalin-degrading enzymes, potentiates Leu-enkephalin-induced anti-allodynic and antinociceptive effects in mice. Jpn.J.Pharmacol. 87 261 PMID: 11829145

Liang et al (2001) The endogenous opioid spinorphin blocks fMet-Leu-Phe-induced neutrophil chemotaxis by acting as a specific antagonist at the N-formylpeptide receptor subtype FPR. J.Immunol. 167 6609 PMID: 11714831

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Keywords: Spinorphin, Spinorphin supplier, Potent, P2X3, antagonists, Enkephalin-degrading, ACE, inhibitors, inhibits, Receptors, Purinergic, purinoceptors, Angiotensin-Converting, Enzyme, Proteinases, Proteases, Other, 2931, Tocris Bioscience

Citations for Spinorphin

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Currently there are no citations for Spinorphin.

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