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Description: Potent and selective ERα Degrader (SNIPER)
Chemical Name: (2S)-N-[(1S)-1-Cyclohexyl-2-[(2S)-2-[4-[3-[[14-[4-[1-(4-hydroxyphenyl)-2-phenyl-1-buten-1-yl]phenoxy]-12-methyl-11-oxo-3,6,9-trioxa-12-azatetradec-1-yl]oxy]benzoyl]-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)propanamide
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity for SNIPER(ER)-87

SNIPER(ER)-87 is a potent and selective estrogen receptor α (ERα) Degrader (Specific and Nongenetic IAP-dependent Protein Erasers or SNIPER) (DC50 = 3 nM). SNIPER(ER)-87 comprises the IAP binding ligand LCL 161 (Cat. No. 7178) joined by a linker to the estrogen-binding moiety 4-hydroxytamoxifen (Cat. No. 3412). The product decreases ERα levels in breast cancer cells in vitro and in mouse ovaries in vivo. SNIPER(ER)-87 also reduces ERα levels and inhibits tumor proliferation in breast cancer xenograft mouse models. ER alpha/NR3A1 antibodies validated for Simple Western™ (automated Western Blot) instruments and Western Blot also available: Catalog # AF 5715 and MAB57151.

Technical Data for SNIPER(ER)-87

M. Wt 1044.32
Formula C59H73N5O10S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2222354-91-6
PubChem ID 155563319

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SNIPER(ER)-87

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 104.43 100

Preparing Stock Solutions for SNIPER(ER)-87

The following data is based on the product molecular weight 1044.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.96 mL 4.79 mL 9.58 mL
5 mM 0.19 mL 0.96 mL 1.92 mL
10 mM 0.1 mL 0.48 mL 0.96 mL
50 mM 0.02 mL 0.1 mL 0.19 mL

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Product Datasheets for SNIPER(ER)-87

References for SNIPER(ER)-87

References are publications that support the biological activity of the product.

Ohoka et al (2017) In vivo knockdown of pathogenic proteins via specific and nongenetic inhibitor of apoptosis protein (IAP)-dependent protein erasers (SNIPERs). J.Biol.Chem. 292 4556 PMID: 28154167

If you know of a relevant reference for SNIPER(ER)-87, please let us know.

Keywords: SNIPER(ER)-87, SNIPER(ER)-87 supplier, estrogen, receptor, alpha, alfa, ERa, ER, SNIPER, Specific, and, Nongenetic, IAP-dependent, Protein, Erasers, Degrader, degrades, Targeted, protein, degradation, TPD, XIAP, inhibitor, of, apoptosis, Estrogen, Related, Receptors, Active, Degraders, 7120, Tocris Bioscience

Citations for SNIPER(ER)-87

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Literature in this Area

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Targeted Protein Degradation Research Product Guide

Targeted Protein Degradation Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Ubiquitin-Proteasome System Proteins
  • Assays for Protein Degradation
Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics in Cancer Poster

Epigenetics in Cancer Poster

This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.

Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia