Estrogen receptor antagonist. Tamoxifen (Cat. No. 0999) metabolite; exhibits greater potency than the parent compound. Chemotherapeutic agent. Also activates intein-linked inactive Cas9, reducing off-target CRISPR-mediated gene editing; system has ~25-fold higher specificity than wtCas9.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 387.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.58 mL||12.9 mL||25.81 mL|
|5 mM||0.52 mL||2.58 mL||5.16 mL|
|10 mM||0.26 mL||1.29 mL||2.58 mL|
|50 mM||0.05 mL||0.26 mL||0.52 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Jordan et al (1977) A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity. J.Endocrinology 75 305 PMID: 591813
Desta et al (2004) Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: Prominent roles for CYP3A and CYP2D6. J.Pharm.Exp.Ther. 310 1062 PMID: 15159443
Yu and Forman (2003) Simple and efficient production of (Z)-4-hydroxytamoxifen, a potent estrogen receptor modulator. J.Org.Chem. 68 9489 PMID: 14629178
Davis et al (2015) Small molecule-triggered Cas9 protein with improved genome-editing specificity. Nat.Chem.Biol. 11 316 PMID: 25848930
If you know of a relevant reference for (Z)-4-Hydroxytamoxifen, please let us know.
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Keywords: estrogen receptors antagonists ER 4-hydroxy-TAM antiestrogens antioestrogens SERM selective modulators CRISPR Cas9-intein 4-OH-TAM Estrogen and Related Receptors
Citations for (Z)-4-Hydroxytamoxifen
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